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IMCIS SIGNED

Individualised medicine in chronic inflammatory skin diseases

Total Cost €

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EC-Contrib. €

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Partnership

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 IMCIS project word cloud

Explore the words cloud of the IMCIS project. It provides you a very rough idea of what is the project "IMCIS" about.

deep    magnitude    intelligent    full    responders    pathogenic    demanded    skin    attribute    quality    substantially    breaking    triggers    more    model    gene    imprecise    ae    characterised    heterogeneity    life    86    billion    socio    candidate    phenotyping    laboratory    inflammatory    implying    lesional    prediction    primary    informaticians    medicine    insufficient    optimal    atopic    character    bio    therapy    regions    individual    histological    link    economic    specialists    gets    efforts    patient    psoriasis    intensified    safe    basic    attributes    million    chronic    devastating    validated    lack    unmet    imply    precision    models    medical    rough    substantial    despite    suffer    ground    consequently    molecular    diagnostic    health    individualised    inflamed    biological    idea    citizens    relevance    events    diagnosing    culture    care    eczema    pathogenesis    therapies    innovative    clinical    network    gap    assigned    diseases    undertreated    cancer    direct    cell    possibilities    signatures    molecules    shortcomings    brain   

Project "IMCIS" data sheet

The following table provides information about the project.

Coordinator
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN 

Organization address
address: ISMANINGER STRASSE 22
city: MUENCHEN
postcode: 81675
website: http://www.med.tu.muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙495˙906 €
 EC max contribution 1˙495˙906 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN DE (MUENCHEN) coordinator 1˙495˙906.00

Map

 Project objective

More than 100 million EU citizens suffer from chronic inflammatory skin diseases such as psoriasis and atopic eczema (AE). The diseases imply a devastating life quality similar to that of cancer, and cause direct socio-economic costs in the magnitude of 100 billion Euro each year in the EU. Despite all efforts, psoriasis and AE remain undertreated and the concept of individualised (also called precision) medicine could not be established in the field. Consequently, intensified research is demanded by organisations such as the WHO. Unmet medical needs are 1) a diagnostic gap, 2) lack of prediction possibilities to define the optimal therapy for an individual patient, and 3) a substantial number of non-responders to therapies. Reasons for these shortcomings are the heterogeneity of both psoriasis and AE and insufficient collaboration of clinical specialists, basic researchers, and bio-informaticians. This proposal aims at improving health care of inflammatory skin diseases by implying the concept of individualised medicine. The crucial step towards this goal is the ground-breaking idea to link deep clinical phenotyping to molecular signatures in lesional skin. Deep phenotyping means each patient is characterised by 86 clinical, histological, and laboratory attributes rather than the imprecise state-of-the art approach of rough diagnosing. Each attribute gets assigned to molecular events in lesional skin. Gene regions as well as key pathogenic molecules are identified in a novel gene network of inflamed skin, referred to as BRAIN (biological relevance assigned intelligent network). Candidate targets get validated using state-of-the-art cell culture systems and full skin models. This innovative and ambitious approach will substantially improve our knowledge of the pathogenesis and primary triggers of both psoriasis and AE, safe European health care systems direct costs in the magnitude of 10 billion Euro, and have a model character for complex diseases in general.

 Publications

year authors and title journal last update
List of publications.
2017 Kilian Eyerich, Stefanie Eyerich
Immune response patterns in non-communicable inflammatory skin diseases
published pages: , ISSN: 0926-9959, DOI: 10.1111/jdv.14673
Journal of the European Academy of Dermatology and Venereology 2019-07-08
2018 Felix Lauffer, Manja Jargosch, Linda Krause, Natalie Garzorz-Stark, Regina Franz, Sophie Roenneberg, Alexander Böhner, Nikola S. Mueller, Fabian J. Theis, Carsten B. Schmidt-Weber, Tilo Biedermann, Stefanie Eyerich, Kilian Eyerich
Type I Immune Response Induces Keratinocyte Necroptosis and Is Associated with Interface Dermatitis
published pages: 1785-1794, ISSN: 0022-202X, DOI: 10.1016/j.jid.2018.02.034
Journal of Investigative Dermatology 138/8 2019-07-08
2015 Kilian Eyerich, Stefanie Eyerich, Tilo Biedermann
The Multi-Modal Immune Pathogenesis of Atopic Eczema
published pages: 788-801, ISSN: 1471-4906, DOI: 10.1016/j.it.2015.10.006
Trends in Immunology 36/12 2019-07-08
2016 N. Garzorz, J. Thomas, B. Eberlein, C. Haferlach, J. Ring, T. Biedermann, C. Schmidt-Weber, K. Eyerich, F. Seifert, S. Eyerich
Newly acquired kiwi fruit allergy after bone marrow transplantation from a kiwi-allergic donor
published pages: 1136-1139, ISSN: 0926-9959, DOI: 10.1111/jdv.13617
Journal of the European Academy of Dermatology and Venereology 30/7 2019-07-08
2017 M. Lovászi, M. Mattii, K. Eyerich, A. Gácsi, E. Csányi, D. Kovács, R. Rühl, A. Szegedi, L. Kemény, M. Ståhle, C.C. Zouboulis, S. Eyerich, D. Törőcsik
Sebum lipids influence macrophage polarization and activation
published pages: , ISSN: 0007-0963, DOI: 10.1111/bjd.15754
British Journal of Dermatology 2019-07-08
2017 Julia Hiller, Beate Hagl, Renate Effner, Anne Puel, Martin Schaller, Birgit Mascher, Stefanie Eyerich, Kilian Eyerich, Annette F. Jansson, Johannes Ring, Jean-Laurent Casanova, Ellen D. Renner, Claudia Traidl-Hoffmann
STAT1 gain of function and STAT3 loss of function mutations impair IL-17 and IL-22 immunity associated with CMC
published pages: , ISSN: 0022-202X, DOI: 10.1016/j.jid.2017.09.035
Journal of Investigative Dermatology 2019-07-08
2017 Regina Franz, Nathalie Ritter, Rüdiger Hein, Tilo Biedermann, Mohammed Al-Sisi, Kilian Eyerich, Natalie Garzorz-Stark, Christian Andres
Toll-Like Receptor 7 Staining in Malignant Epithelial Tumors
published pages: 742-746, ISSN: 0193-1091, DOI: 10.1097/DAD.0000000000000784
The American Journal of Dermatopathology 39/10 2019-07-08
2017 A. Zink, M. Herrmann, T. Fischer, F. Lauffer, N. Garzorz-Stark, A. Böhner, C.D. Spinner, T. Biedermann, K. Eyerich
Addiction: an underestimated problem in psoriasis health care
published pages: 1308-1315, ISSN: 0926-9959, DOI: 10.1111/jdv.14204
Journal of the European Academy of Dermatology and Venereology 31/8 2019-07-08
2016 Alexander Böhner, Sophie Roenneberg, Kilian Eyerich, Bernadette Eberlein, Tilo Biedermann
Acute Generalized Pustular Psoriasis Treated With the IL-17A Antibody Secukinumab
published pages: 482, ISSN: 2168-6068, DOI: 10.1001/jamadermatol.2015.4686
JAMA Dermatology 152/4 2019-07-08
2016 Natalie Garzorz-Stark, Linda Krause, Felix Lauffer, Anne Atenhan, Jenny Thomas, Sebastian P. Stark, Regina Franz, Stephan Weidinger, Anna Balato, Nikola S. Mueller, Fabian J. Theis, Johannes Ring, Carsten B. Schmidt-Weber, Tilo Biedermann, Stefanie Eyerich, Kilian Eyerich
A novel molecular disease classifier for psoriasis and eczema
published pages: 767-774, ISSN: 0906-6705, DOI: 10.1111/exd.13077
Experimental Dermatology 25/10 2019-07-08
2017 M. Mattii, M. Lovászi, N. Garzorz, A. Atenhan, M. Quaranta, F. Lauffer, A. Konstantinow, M. Küpper, C. C. Zouboulis, L. Kemeny, K. Eyerich, C. B. Schmidt-Weber, D. Törőcsik, S. Eyerich
Sebocytes contribute to skin inflammation by promoting the differentiation of Th17 cells
published pages: , ISSN: 0007-0963, DOI: 10.1111/bjd.15879
British Journal of Dermatology 2019-07-08
2017 Kilian Eyerich, Valentina Dimartino, Andrea Cavani
IL-17 and IL-22 in immunity: Driving protection and pathology
published pages: 607-614, ISSN: 0014-2980, DOI: 10.1002/eji.201646723
European Journal of Immunology 47/4 2019-07-08
2015 N. Garzorz, M. Alsisi, A. Todorova, A. Atenhan, J. Thomas, F. Lauffer, J. Ring, C. Schmidt-Weber, T. Biedermann, S. Eyerich, K. Eyerich
Dissecting susceptibility from exogenous triggers: the model of alopecia areata and associated inflammatory skin diseases
published pages: 2429-2435, ISSN: 0926-9959, DOI: 10.1111/jdv.13325
Journal of the European Academy of Dermatology and Venereology 29/12 2019-07-08
2015 Simona Avitabile, Teresa Odorisio, Stefania Madonna, Stefanie Eyerich, Liliana Guerra, Kilian Eyerich, Giovanna Zambruno, Andrea Cavani, Francesca Cianfarani
Interleukin-22 Promotes Wound Repair in Diabetes by Improving Keratinocyte Pro-Healing Functions
published pages: 2862-2870, ISSN: 0022-202X, DOI: 10.1038/jid.2015.278
Journal of Investigative Dermatology 135/11 2019-07-08
2017 Natalie Garzorz-Stark, Felix Lauffer, Linda Krause, Jenny Thomas, Anne Atenhan, Regina Franz, Sophie Roenneberg, Alexander Boehner, Manja Jargosch, Richa Batra, Nikola S. Mueller, Stefan Haak, Christina Groß, Olaf Groß, Claudia Traidl-Hoffmann, Fabian J. Theis, Carsten B. Schmidt-Weber, Tilo Biedermann, Stefanie Eyerich, Kilian Eyerich
Toll-like receptor 7/8 agonists stimulate plasmacytoid dendritic cells to initiate T H 17-deviated acute contact dermatitis in human subjects
published pages: , ISSN: 0091-6749, DOI: 10.1016/j.jaci.2017.07.045
Journal of Allergy and Clinical Immunology 2019-07-08
2017 Mathias Schwarz, Natalie Garzorz-Stark, Kilian Eyerich, Juan Aguirre, Vasilis Ntziachristos
Motion correction in optoacoustic mesoscopy
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-11277-y
Scientific Reports 7/1 2019-07-08
2017 A.M. Drucker, K. Eyerich, M.S. de Bruin-Weller, J.P. Thyssen, P.I. Spuls, A.D. Irvine, G. Girolomoni, S. Dhar, C. Flohr, D.F. Murrell, A.S. Paller, E. Guttman-Yassky
Use of systemic corticosteroids for atopic dermatitis: International Eczema Council consensus statement
published pages: , ISSN: 0007-0963, DOI: 10.1111/bjd.15928
British Journal of Dermatology 2019-07-08
2019 Athanasios Damialis, Franziska Häring, Mehmet Gökkaya, Denise Rauer, Matthias Reiger, Sebastian Bezold, Nikolaos Bounas-Pyrros, Kilian Eyerich, Antonia Todorova, Gertrud Hammel, Stefanie Gilles, Claudia Traidl-Hoffmann
Human exposure to airborne pollen and relationships with symptoms and immune responses: Indoors versus outdoors, circadian patterns and meteorological effects in alpine and urban environments
published pages: 190-199, ISSN: 0048-9697, DOI: 10.1016/j.scitotenv.2018.10.366
Science of The Total Environment 653 2019-05-10
2016 Thomas Werfel, Jean-Pierre Allam, Tilo Biedermann, Kilian Eyerich, Stefanie Gilles, Emma Guttman-Yassky, Wolfram Hoetzenecker, Edward Knol, Hans-Uwe Simon, Andreas Wollenberg, Thomas Bieber, Roger Lauener, Peter Schmid-Grendelmeier, Claudia Traidl-Hoffmann, Cezmi A. Akdis
Cellular and molecular immunologic mechanisms in patients with atopic dermatitis
published pages: 336-349, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2016.06.010
Journal of Allergy and Clinical Immunology 138/2 2019-05-10
2018 B. Hindelang, J. Aguirre, M. Schwarz, A. Berezhnoi, K. Eyerich, V. Ntziachristos, T. Biedermann, U. Darsow
Non-invasive imaging in dermatology and the unique potential of Raster-Scan Optoacoustic Mesoscopy (RSOM)
published pages: , ISSN: 0926-9959, DOI: 10.1111/jdv.15342
Journal of the European Academy of Dermatology and Venereology 2019-05-10
2018 Anna Caroline Pilz, Sophie Roenneberg, Tilo Biedermann, Kilian Eyerich
Ixekizumab for acrodermatitis continua
published pages: 907-910, ISSN: 1610-0379, DOI: 10.1111/ddg.13568
JDDG: Journal der Deutschen Dermatologischen Gesellschaft 16/7 2019-05-10
2019 Kilian Eyerich, Sara J. Brown, Bethany E. Perez White, Reiko J. Tanaka, Robert Bissonette, Sandipan Dhar, Thomas Bieber, Dirk J. Hijnen, Emma Guttman-Yassky, Alan Irvine, Jacob P. Thyssen, Christian Vestergaard, Thomas Werfel, Andreas Wollenberg, Amy S. Paller, Nick J. Reynolds
Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council
published pages: 36-45, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.10.033
Journal of Allergy and Clinical Immunology 143/1 2019-05-10
2018 Stefanie Eyerich, Kilian Eyerich, Claudia Traidl-Hoffmann, Tilo Biedermann
Cutaneous Barriers and Skin Immunity: Differentiating A Connected Network
published pages: 315-327, ISSN: 1471-4906, DOI: 10.1016/j.it.2018.02.004
Trends in Immunology 39/4 2019-05-10
2018 J. Thomas, M. Küpper, R. Batra, M. Jargosch, A. Atenhan, V. Baghin, L. Krause, F. Lauffer, T. Biedermann, F.J. Theis, K. Eyerich, S. Eyerich, N. Garzorz-Stark
Is the humoral immunity dispensable for the pathogenesis of psoriasis?
published pages: , ISSN: 0926-9959, DOI: 10.1111/jdv.15101
Journal of the European Academy of Dermatology and Venereology 2019-05-10
2018 J. Aguirre, B. Hindelang, Andrei Berezhnoi, U. Darsow, F. Lauffer, K. Eyerich, T. Biedermann, V. Ntziachristos
Assessing nailfold microvascular structure with ultra-wideband raster-scan optoacoustic mesoscopy
published pages: 31-37, ISSN: 2213-5979, DOI: 10.1016/j.pacs.2018.02.002
Photoacoustics 10 2019-05-10
2018 Alexander Boehner, Alexander A. Navarini, Kilian Eyerich
Generalized pustular psoriasis - a model disease for specific targeted immunotherapy, systematic review
published pages: 1067-1077, ISSN: 0906-6705, DOI: 10.1111/exd.13699
Experimental Dermatology 27/10 2019-05-10
2018 Nick Vandeghinste, Jürgen Klattig, Catherine Jagerschmidt, Stéphanie Lavazais, Florence Marsais, Jan D. Haas, Marielle Auberval, Felix Lauffer, Tara Moran, Mate Ongenaert, Maarten Van Balen, Sonia Dupont, Liên Lepescheux, Teresa Garcia, Stefan Härtle, Kilian Eyerich, Padraic G. Fallon, Reginald Brys, Stefan Steidl
Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis
published pages: 1555-1563, ISSN: 0022-202X, DOI: 10.1016/j.jid.2018.01.036
Journal of Investigative Dermatology 138/7 2019-05-10
2018 Can Altunbulakli, Matthias Reiger, Avidan U. Neumann, Natalie Garzorz-Stark, Megan Fleming, Claudia Huelpuesch, Francesc Castro-Giner, Kilian Eyerich, Cezmi A. Akdis, Claudia Traidl-Hoffmann
Relations between epidermal barrier dysregulation and Staphylococcus species–dominated microbiome dysbiosis in patients with atopic dermatitis
published pages: 1643-1647.e12, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.07.005
Journal of Allergy and Clinical Immunology 142/5 2019-05-10

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