Explore the words cloud of the INTRICARE project. It provides you a very rough idea of what is the project "INTRICARE" about.
The following table provides information about the project.
|Coordinator Country||Netherlands [NL]|
|Total cost||3˙832˙965 €|
|EC max contribution||3˙832˙965 € (100%)|
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
|Duration (year-month-day)||from 2017-03-01 to 2021-02-28|
Take a look of project's partnership.
|1||UNIVERSITEIT MAASTRICHT||NL (MAASTRICHT)||coordinator||1˙532˙245.00|
|2||UNIVERSITAETSKLINIKUM AACHEN||DE (AACHEN)||participant||1˙246˙082.00|
|3||KAROLINSKA INSTITUTET||SE (STOCKHOLM)||participant||1˙054˙637.00|
Cardiovascular disease remains one of the major challenges of contemporary society, being responsible for a staggering 47% of deaths in Europe. Vascular calcification in particular requires immediate attention as it is strongly associated with increased cardiovascular mortality and morbidity, and is recognised as an important independent risk factor for cardiovascular death. Recent reports demonstrate that especially punctuated and spotty calcifications (microcalcifications) in the plaque are life-threatening. Microcalcifications are particularly prominent in the vulnerable atherosclerotic plaque that is at high risk of rupture, a cardinal event that can cause thrombosis, infarct, cardiac arrest, stroke and death. In fact, 20% of European deaths are directly attributable to thrombotic rupture of a vulnerable plaque; a clear indication that current treatments and preventive measures are insufficient. Recent findings suggest a link between vascular smooth muscle cell phenotype mediated calcification and inflammation, which could underlie the plaque destabilising effects of microcalcification. However, a comprehensive view on what causes microcalcification and its impact on plaque stability remains elusive and there is an urgent need to translate experimental findings into adequate diagnostic, preventive and therapeutic solutions. INTRICARE is shaped to address the urgent unmet medical needs concerning calcification-induced vulnerable plaques and is guided by the academic and industrial demand for a new generation of entrepreneurial scientists that have the skills, expertise and knowhow to expedite our understanding of vascular calcification and translation thereof into concrete, effective clinical solutions. The INTRICARE ESRs harbour ongoing vitamin K-supplementation trials that will be pivotal in the identification of selective biomarkers for microcalcification and subsequent development of strategies for prevention or amelioration of vulnerable plaque formation.
|Call for applicants||Documents, reports||2019-07-23 15:26:42|
|Supervisory Board of the Network||Documents, reports||2019-07-23 15:26:40|
|Website||Websites, patent fillings, videos etc.||2019-07-23 15:26:39|
|Joint review papers||Open Research Data Pilot||2019-07-23 15:26:40|
Take a look to the deliverables list in detail: detailed list of INTRICARE deliverables.
|year||authors and title||journal||last update|
Eva KarlÃ¶f, Till Seime, Nuno Dias, Mariette Lengquist, Anna Witasp, HÃ¥kan Almqvist, Malin Kronqvist, Jesper R. GÃ¥din, Jacob Odeberg, Lars Maegdefessel, Peter Stenvinkel, Ljubica Perisic Matic, Ulf Hedin
Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization
published pages: , ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2019.05.005
Jan Bucerius, Ingrid Dijkgraaf, Felix M. Mottaghy, Leon J. Schurgers
Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond 18F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon
published pages: 251-265, ISSN: 1619-7070, DOI: 10.1007/s00259-018-4176-z
|European Journal of Nuclear Medicine and Molecular Imaging 46/1||2019-05-27|
Hideyuki Mukai, Lu Dai, Zhimin Chen, Bengt Lindholm, Jonaz Ripsweden, Torkel B Brismar, Olof HeimbÃ¼rger, Peter Barany, Abdul Rashid Qureshi, Magnus SÃ¶derberg, Magnus BÃ¤ck, Peter Stenvinkel
Inverse J-shaped relation between coronary arterial calcium density and mortality in advanced chronic kidney disease
published pages: , ISSN: 0931-0509, DOI: 10.1093/ndt/gfy352
|Nephrology Dialysis Transplantation||2019-05-23|
Stefan Reinhold, W. Matthijs Blankesteijn
Wnt/Î²-Catenin Inhibitor Dickkopf 1
published pages: 121-123, ISSN: 1079-5642, DOI: 10.1161/atvbaha.118.312144
|Arteriosclerosis, Thrombosis, and Vascular Biology 39/2||2019-05-23|
Maurice Halder, Ploingarm Petsophonsakul, Asim Akbulut, Angelina Pavlic, Frode Bohan, Eric Anderson, Katarzyna Maresz, Rafael Kramann, Leon Schurgers
Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease
published pages: 896, ISSN: 1422-0067, DOI: 10.3390/ijms20040896
|International Journal of Molecular Sciences 20/4||2019-05-27|
Leon J. Schurgers, Asim C. Akbulut, Dawid M. Kaczor, Maurice Halder, Rory R. Koenen, Rafael Kramann
Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles
published pages: , ISSN: 2297-055X, DOI: 10.3389/fcvm.2018.00036
|Frontiers in Cardiovascular Medicine 5||2019-05-23|
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The information about "INTRICARE" are provided by the European Opendata Portal: CORDIS opendata.