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INTRICARE SIGNED

International Network for Training on Risks of vascular Intimal Calcification And roads to Regression of cardiovascular diseasE

Total Cost €

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EC-Contrib. €

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Partnership

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 INTRICARE project word cloud

Explore the words cloud of the INTRICARE project. It provides you a very rough idea of what is the project "INTRICARE" about.

prominent    urgent    mortality    therapeutic    vulnerable    arrest    elusive    deaths    guided    knowhow    preventive    medical    subsequent    insufficient    independent    link    cardiac    20    atherosclerotic    staggering    indication    entrepreneurial    morbidity    microcalcifications    47    suggest    industrial    vitamin    strategies    demand    spotty    stability    intricare    infarct    translation    treatments    mediated    calcification    ongoing    underlie    expedite    diagnostic    prevention    pivotal    academic    muscle    event    view    plaque    generation    concerning    plaques    vascular    society    risk    cardinal    causes    cardiovascular    attributable    trials    selective    identification    esrs    fact    recognised    microcalcification    scientists    expertise    thrombosis    shaped    smooth    death    cell    disease    harbour    responsible    experimental    contemporary    amelioration    biomarkers    threatening    life    stroke    destabilising    phenotype    unmet    clear    punctuated    supplementation    reports    skills    thereof    rupture    solutions    thrombotic    inflammation    clinical    calcifications    translate   

Project "INTRICARE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT MAASTRICHT 

Organization address
address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD
website: http://www.maastrichtuniversity.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.intricare.eu
 Total cost 3˙832˙965 €
 EC max contribution 3˙832˙965 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-EJD
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 1˙532˙245.00
2    UNIVERSITAETSKLINIKUM AACHEN DE (AACHEN) participant 1˙246˙082.00
3    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 1˙054˙637.00

Map

 Project objective

Cardiovascular disease remains one of the major challenges of contemporary society, being responsible for a staggering 47% of deaths in Europe. Vascular calcification in particular requires immediate attention as it is strongly associated with increased cardiovascular mortality and morbidity, and is recognised as an important independent risk factor for cardiovascular death. Recent reports demonstrate that especially punctuated and spotty calcifications (microcalcifications) in the plaque are life-threatening. Microcalcifications are particularly prominent in the vulnerable atherosclerotic plaque that is at high risk of rupture, a cardinal event that can cause thrombosis, infarct, cardiac arrest, stroke and death. In fact, 20% of European deaths are directly attributable to thrombotic rupture of a vulnerable plaque; a clear indication that current treatments and preventive measures are insufficient. Recent findings suggest a link between vascular smooth muscle cell phenotype mediated calcification and inflammation, which could underlie the plaque destabilising effects of microcalcification. However, a comprehensive view on what causes microcalcification and its impact on plaque stability remains elusive and there is an urgent need to translate experimental findings into adequate diagnostic, preventive and therapeutic solutions. INTRICARE is shaped to address the urgent unmet medical needs concerning calcification-induced vulnerable plaques and is guided by the academic and industrial demand for a new generation of entrepreneurial scientists that have the skills, expertise and knowhow to expedite our understanding of vascular calcification and translation thereof into concrete, effective clinical solutions. The INTRICARE ESRs harbour ongoing vitamin K-supplementation trials that will be pivotal in the identification of selective biomarkers for microcalcification and subsequent development of strategies for prevention or amelioration of vulnerable plaque formation.

 Deliverables

List of deliverables.
Call for applicants Documents, reports 2019-07-23 15:26:42
Supervisory Board of the Network Documents, reports 2019-07-23 15:26:40
Website Websites, patent fillings, videos etc. 2019-07-23 15:26:39
Joint review papers Open Research Data Pilot 2019-07-23 15:26:40

Take a look to the deliverables list in detail:  detailed list of INTRICARE deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Eva Karlöf, Till Seime, Nuno Dias, Mariette Lengquist, Anna Witasp, Håkan Almqvist, Malin Kronqvist, Jesper R. Gådin, Jacob Odeberg, Lars Maegdefessel, Peter Stenvinkel, Ljubica Perisic Matic, Ulf Hedin
Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization
published pages: , ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2019.05.005
Atherosclerosis 2019-09-04
2019 Jan Bucerius, Ingrid Dijkgraaf, Felix M. Mottaghy, Leon J. Schurgers
Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond 18F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon
published pages: 251-265, ISSN: 1619-7070, DOI: 10.1007/s00259-018-4176-z
European Journal of Nuclear Medicine and Molecular Imaging 46/1 2019-05-27
2018 Hideyuki Mukai, Lu Dai, Zhimin Chen, Bengt Lindholm, Jonaz Ripsweden, Torkel B Brismar, Olof Heimbürger, Peter Barany, Abdul Rashid Qureshi, Magnus Söderberg, Magnus Bäck, Peter Stenvinkel
Inverse J-shaped relation between coronary arterial calcium density and mortality in advanced chronic kidney disease
published pages: , ISSN: 0931-0509, DOI: 10.1093/ndt/gfy352
Nephrology Dialysis Transplantation 2019-05-23
2019 Stefan Reinhold, W. Matthijs Blankesteijn
Wnt/β-Catenin Inhibitor Dickkopf 1
published pages: 121-123, ISSN: 1079-5642, DOI: 10.1161/atvbaha.118.312144
Arteriosclerosis, Thrombosis, and Vascular Biology 39/2 2019-05-23
2019 Maurice Halder, Ploingarm Petsophonsakul, Asim Akbulut, Angelina Pavlic, Frode Bohan, Eric Anderson, Katarzyna Maresz, Rafael Kramann, Leon Schurgers
Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease
published pages: 896, ISSN: 1422-0067, DOI: 10.3390/ijms20040896
International Journal of Molecular Sciences 20/4 2019-05-27
2018 Leon J. Schurgers, Asim C. Akbulut, Dawid M. Kaczor, Maurice Halder, Rory R. Koenen, Rafael Kramann
Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles
published pages: , ISSN: 2297-055X, DOI: 10.3389/fcvm.2018.00036
Frontiers in Cardiovascular Medicine 5 2019-05-23

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The information about "INTRICARE" are provided by the European Opendata Portal: CORDIS opendata.

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