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International Network for Training on Risks of vascular Intimal Calcification And roads to Regression of cardiovascular diseasE

Total Cost €


EC-Contrib. €






 INTRICARE project word cloud

Explore the words cloud of the INTRICARE project. It provides you a very rough idea of what is the project "INTRICARE" about.

suggest    punctuated    biomarkers    harbour    cardiac    vitamin    ongoing    trials    pivotal    link    medical    view    vascular    generation    treatments    risk    underlie    knowhow    insufficient    industrial    selective    contemporary    urgent    47    phenotype    responsible    mortality    life    preventive    morbidity    causes    spotty    thrombotic    intricare    fact    stroke    atherosclerotic    event    solutions    amelioration    death    prominent    translate    cardinal    indication    unmet    reports    attributable    calcifications    threatening    prevention    expedite    guided    smooth    cell    infarct    elusive    inflammation    identification    vulnerable    deaths    translation    strategies    entrepreneurial    disease    cardiovascular    thereof    plaques    destabilising    academic    independent    shaped    skills    clear    microcalcification    arrest    demand    microcalcifications    concerning    plaque    muscle    esrs    20    rupture    staggering    stability    expertise    thrombosis    supplementation    clinical    recognised    calcification    therapeutic    mediated    society    diagnostic    experimental    scientists    subsequent   

Project "INTRICARE" data sheet

The following table provides information about the project.


Organization address
address: Minderbroedersberg 4-6
postcode: 6200 MD

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 3˙832˙965 €
 EC max contribution 3˙832˙965 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-EJD
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2021-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 1˙532˙245.00
2    UNIVERSITAETSKLINIKUM AACHEN DE (AACHEN) participant 1˙246˙082.00
3    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 1˙054˙637.00


 Project objective

Cardiovascular disease remains one of the major challenges of contemporary society, being responsible for a staggering 47% of deaths in Europe. Vascular calcification in particular requires immediate attention as it is strongly associated with increased cardiovascular mortality and morbidity, and is recognised as an important independent risk factor for cardiovascular death. Recent reports demonstrate that especially punctuated and spotty calcifications (microcalcifications) in the plaque are life-threatening. Microcalcifications are particularly prominent in the vulnerable atherosclerotic plaque that is at high risk of rupture, a cardinal event that can cause thrombosis, infarct, cardiac arrest, stroke and death. In fact, 20% of European deaths are directly attributable to thrombotic rupture of a vulnerable plaque; a clear indication that current treatments and preventive measures are insufficient. Recent findings suggest a link between vascular smooth muscle cell phenotype mediated calcification and inflammation, which could underlie the plaque destabilising effects of microcalcification. However, a comprehensive view on what causes microcalcification and its impact on plaque stability remains elusive and there is an urgent need to translate experimental findings into adequate diagnostic, preventive and therapeutic solutions. INTRICARE is shaped to address the urgent unmet medical needs concerning calcification-induced vulnerable plaques and is guided by the academic and industrial demand for a new generation of entrepreneurial scientists that have the skills, expertise and knowhow to expedite our understanding of vascular calcification and translation thereof into concrete, effective clinical solutions. The INTRICARE ESRs harbour ongoing vitamin K-supplementation trials that will be pivotal in the identification of selective biomarkers for microcalcification and subsequent development of strategies for prevention or amelioration of vulnerable plaque formation.


List of deliverables.
Call for applicants Documents, reports 2019-07-23 15:26:42
Supervisory Board of the Network Documents, reports 2019-07-23 15:26:40
Website Websites, patent fillings, videos etc. 2019-07-23 15:26:39
Joint review papers Open Research Data Pilot 2019-07-23 15:26:40

Take a look to the deliverables list in detail:  detailed list of INTRICARE deliverables.


year authors and title journal last update
List of publications.
2019 Eva Karlöf, Till Seime, Nuno Dias, Mariette Lengquist, Anna Witasp, Håkan Almqvist, Malin Kronqvist, Jesper R. Gådin, Jacob Odeberg, Lars Maegdefessel, Peter Stenvinkel, Ljubica Perisic Matic, Ulf Hedin
Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization
published pages: , ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2019.05.005
Atherosclerosis 2019-09-04
2019 Jan Bucerius, Ingrid Dijkgraaf, Felix M. Mottaghy, Leon J. Schurgers
Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond 18F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon
published pages: 251-265, ISSN: 1619-7070, DOI: 10.1007/s00259-018-4176-z
European Journal of Nuclear Medicine and Molecular Imaging 46/1 2019-05-27
2018 Hideyuki Mukai, Lu Dai, Zhimin Chen, Bengt Lindholm, Jonaz Ripsweden, Torkel B Brismar, Olof Heimbürger, Peter Barany, Abdul Rashid Qureshi, Magnus Söderberg, Magnus Bäck, Peter Stenvinkel
Inverse J-shaped relation between coronary arterial calcium density and mortality in advanced chronic kidney disease
published pages: , ISSN: 0931-0509, DOI: 10.1093/ndt/gfy352
Nephrology Dialysis Transplantation 2019-05-23
2019 Stefan Reinhold, W. Matthijs Blankesteijn
Wnt/β-Catenin Inhibitor Dickkopf 1
published pages: 121-123, ISSN: 1079-5642, DOI: 10.1161/atvbaha.118.312144
Arteriosclerosis, Thrombosis, and Vascular Biology 39/2 2019-05-23
2019 Maurice Halder, Ploingarm Petsophonsakul, Asim Akbulut, Angelina Pavlic, Frode Bohan, Eric Anderson, Katarzyna Maresz, Rafael Kramann, Leon Schurgers
Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease
published pages: 896, ISSN: 1422-0067, DOI: 10.3390/ijms20040896
International Journal of Molecular Sciences 20/4 2019-05-27
2018 Leon J. Schurgers, Asim C. Akbulut, Dawid M. Kaczor, Maurice Halder, Rory R. Koenen, Rafael Kramann
Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles
published pages: , ISSN: 2297-055X, DOI: 10.3389/fcvm.2018.00036
Frontiers in Cardiovascular Medicine 5 2019-05-23

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The information about "INTRICARE" are provided by the European Opendata Portal: CORDIS opendata.

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