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MAGNAMED SIGNED

Novel magnetic nanostructures for medical applications

Total Cost €

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EC-Contrib. €

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Partnership

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 MAGNAMED project word cloud

Explore the words cloud of the MAGNAMED project. It provides you a very rough idea of what is the project "MAGNAMED" about.

strategy    nanostructures    sensor    lithography    tumoral    cells    death    vortex    shape    magnetic    designs    mns    reduce    spin    effectiveness    mortality    diagnosis    mnp    sectoral    size    vitro    fabricates    keystones    small    biomarkers    nanoparticles    significantly    techniques    nanometer    detection    interdisciplinary    moment    provoke    alternate    innovative    action    therapeutics    antiferromagnetic    antigen    fail    dimensions    colorectal    limits    stage    diagnostics    unlike    fabricate    giant    functionalization    assays    configurations    efficiency    membrane    planar    detect    suitable    melanoma    broad    nanodisks    dermcidin    gmr    sensitivity    treatment    medical    cross    4000    magnetoresistance    sensors    triggers    carcinoembryonic    chemistry    physics    capability    magneto    annihilation    assesses    concentration    attracted    clinical    magnamed    exploited    explored    technologies    medium    medicine    alternative    beads    limitations    cell    groundbreaking    cancer    nm    mechanical    therapy   

Project "MAGNAMED" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA 

Organization address
address: BARRIO SARRIENA S N
city: LEIOA
postcode: 48940
website: www.ehu.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 846˙000 €
 EC max contribution 846˙000 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2016
 Funding Scheme MSCA-RISE
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA ES (LEIOA) coordinator 310˙500.00
2    UNIVERSIDADE DO PORTO PT (PORTO) participant 148˙500.00
3    VIENNA BIOCENTER CORE FACILITES GMBH AT (WIEN) participant 117˙000.00
4    INESC MICROSISTEMAS E NANOTECNOLGIAS-INSTITUTO DE ENGENHARIA DE SISTEMAS DE COMPUTADORES PARA OS MICROSISTEMAS E AS NANOTECNOLOGIAS PT (LISBOA) participant 99˙000.00
5    ICETA INSTITUTO DE CIENCIAS, TECNOLOGIAS E AGROAMBIENTE DA UNIVERSIDADE DO PORTO PT (PORTO) participant 67˙500.00
6    IMG PHARMA BIOTECH SOCIEDAD LIMITADA ES (DERIO) participant 54˙000.00
7    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) participant 27˙000.00
8    NANOVEX BIOTECHNOLOGIES SL ES (LLANERA) participant 22˙500.00
9    COMISION NACIONAL DE ENERGIA ATOMICA AR (BUENOS AIRES) partner 0.00
10    COMISSAO NACIONAL DE ENERGIA NUCLEAR- CENTRO DE DESENVOLVIMENTO DA TECNOLOGIA NUCLEAR BR (RIO DE JANEIRO) partner 0.00
11    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) partner 0.00
12    THE UNIVERSITY OF TEXAS SYSTEM US (AUSTIN) partner 0.00
13    UNIVERSIDAD DE SANTIAGO DE CHILE CL (SANTIAGO) partner 0.00
14    UNIVERSIDAD TECNICA FEDERICO SANTA MARIA CL (VALPARAISO) partner 0.00
15    UNIVERSIDADE ESTADUAL DE CAMPINAS BR (CAMPINAS SP) partner 0.00

Map

 Project objective

MAGNAMED designs, fabricates, and assesses novel magnetic nanostructures (MNS) with unique spin configurations for innovative diagnostics and therapy techniques. An early stage detection and an effective treatment are keystones to reduce cancer mortality. Current clinical procedures fail to detect small concentration of tumoral biomarkers. Magnetic nanoparticles (MNP), like beads, have attracted much attention for their capability to improve cancer detection limits and treatment technologies. However, there are several limitations to the use of MNP. As an emerging alternative, MNS are being explored. Unlike MNP, MNS (e.g. nanodisks) present a planar shape with novel properties for diagnosis: high magnetic moment and large size, which can significantly improve the sensor sensitivity, and for therapy: due to their planar shape, alternate magnetic fields provoke a magneto-mechanical action on the cell membrane that triggers cell death. The efficiency of MNS in these two medical applications has not been investigated yet for MNS at the nanometer scale. The challenge of this project is to produce MNS with nanometer dimensions suitable for medical applications. Several lithography techniques will be used to fabricate MNS in vortex and antiferromagnetic spin configurations covering a broad size range (40 to 4000 nm). After functionalization, MNS will be exploited in: (i) Diagnostics, using giant magnetoresistance (GMR) sensors for the detection of tumoral biomarkers (dermcidin and carcinoembryonic antigen), and (ii) Therapy, effectiveness of tumoral cell annihilation by the magneto-mechanical action of MNS will be evaluated in vitro assays of melanoma and colorectal cancer cells. MAGNAMED is a cross-sectoral and interdisciplinary project involving Physics, Chemistry and Medicine. Findings will have a medium-term impact on the European strategy for early stage detection of cancer and a long-term impact on the development of novel and groundbreaking therapeutics techniques.

 Publications

year authors and title journal last update
List of publications.
2018 María Francisca Matus, Cristian Vilos, Bruno A. Cisterna, Eduardo Fuentes, Iván Palomo
Nanotechnology and primary hemostasis: Differential effects of nanoparticles on platelet responses
published pages: 1-8, ISSN: 1537-1891, DOI: 10.1016/j.vph.2017.11.004
Vascular Pharmacology 101 2019-09-02
2018 Eduardo Ortega, Beatriz Mora, Carlos Monton, Carolina Redondo, Josefina Arellano, Rafael Morales, Edgar Voelkl, Arturo Ponce
Study of Vortex State in Permalloy Plates Using Optimized Electron Holography
published pages: 952-953, ISSN: 1431-9276, DOI: 10.1017/s1431927618005251
Microscopy and Microanalysis 24/S1 2019-09-02
2017 Felipe Torres, Rafael Morales, Ivan K. Schuller, Miguel Kiwi
Dipole-induced exchange bias
published pages: 17074-17079, ISSN: 2040-3364, DOI: 10.1039/c7nr05491b
Nanoscale 9/43 2019-09-02
2018 Johanna Ábrigo, Fabian Campos, Felipe Simon, Claudia Riedel, Daniel Cabrera, Cristian Vilos, Claudio Cabello-Verrugio
TGF-β requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy
published pages: 253-264, ISSN: 1431-6730, DOI: 10.1515/hsz-2017-0217
Biological Chemistry 399/3 2019-09-02
2019 Rita Soares, Verónica C. Martins, Rita Macedo, Filipe A. Cardoso, Sofia A. M. Martins, Diogo M. Caetano, Pedro H. Fonseca, Vânia Silvério, Susana Cardoso, Paulo P. Freitas
Go with the flow: advances and trends in magnetic flow cytometry
published pages: 1839-1862, ISSN: 1618-2642, DOI: 10.1007/s00216-019-01593-9
Analytical and Bioanalytical Chemistry 411/9 2019-09-02
2017 D. Navas, N. Soriano, F. Béron, C. T. Sousa, K. R. Pirota, J. Torrejon, C. Redondo, R. Morales, C. A. Ross
Microscopic reversal magnetization mechanisms in CoCrPt thin films with perpendicular magnetic anisotropy: Fractal structure versus labyrinth stripe domains
published pages: , ISSN: 2469-9950, DOI: 10.1103/physrevb.96.180403
Physical Review B 96/18 2019-09-02
2018 Beatriz Mora, Arantza Perez-Valle, Carolina Redondo, Maria Dolores Boyano, Rafael Morales
Cost-Effective Design of High-Magnetic Moment Nanostructures for Biotechnological Applications
published pages: 8165-8172, ISSN: 1944-8244, DOI: 10.1021/acsami.7b16779
ACS Applied Materials & Interfaces 10/9 2019-09-02
2019 A. S. Silva, A. Hierro-Rodriguez, S. A. Bunyaev, G. N. Kakazei, O. V. Dobrovolskiy, C. Redondo, R. Morales, H. Crespo, D. Navas
Magnetic properties of permalloy antidot array fabricated by interference lithography
published pages: 35136, ISSN: 2158-3226, DOI: 10.1063/1.5080111
AIP Advances 9/3 2019-09-02
2018 Abhishek Sahu, Youngmin Hwang, Cristian Vilos, Jong-Min Lim, Sunghyun Kim, Won Il Choi, Giyoong Tae
A novel alendronate functionalized nanoprobe for simple colorimetric detection of cancer-associated hypercalcemia
published pages: 13375-13383, ISSN: 2040-3364, DOI: 10.1039/c8nr02570c
Nanoscale 10/28 2019-09-02
2017 Won Il Choi, Abhishek Sahu, Cristian Vilos, Nazila Kamaly, Seong-Min Jo, Jin Hyung Lee, Giyoong Tae
Bioinspired Heparin Nanosponge Prepared by Photo-crosslinking for Controlled Release of Growth Factors
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-14040-5
Scientific Reports 7/1 2019-09-02
2018 María Francisca Matus, Martín Ludueña, Cristian Vilos, Iván Palomo, Marcelo M Mariscal
Atomic-level characterization and cilostazol affinity of poly(lactic acid) nanoparticles conjugated with differentially charged hydrophilic molecules
published pages: 1328-1338, ISSN: 2190-4286, DOI: 10.3762/bjnano.9.126
Beilstein Journal of Nanotechnology 9 2019-09-02
2018 Suellen Moraes, David Navas, Fanny Béron, Mariana Proenca, Kleber Pirota, Célia Sousa, João Araújo
The Role of Cu Length on the Magnetic Behaviour of Fe/Cu Multi-Segmented Nanowires
published pages: 490, ISSN: 2079-4991, DOI: 10.3390/nano8070490
Nanomaterials 8/7 2019-09-02

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