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ArrestAD SIGNED

3-O-sulfated heparan sulfate translocation in altered membrane biology: A new strategy for early population screening and halting Alzheimer’s neurodegeneration

Total Cost €

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EC-Contrib. €

0

Partnership

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 ArrestAD project word cloud

Explore the words cloud of the ArrestAD project. It provides you a very rough idea of what is the project "ArrestAD" about.

neurodegeneration    transcriptomics    gain    refining    accumulation    sme    drug    risk    heparan    upec    sulfates    visionary       animal    strategies    offset    species    neurons    brings    socio    pathology    citizens    preventing    generate    science    diverse    traffic    experimentation    interaction    radically    initial    classic    nor    altered    diagnosis    models    circulating    proving    portfolio    cells    economy    multidisciplinary    cure    clinics    society    underpinning    thinking    sulfate    ing    arresting    treatment    intracellular    aggregation    hallmarks    demonstrating    vision    benefit    economic    specialized    ad    abnormal    societal    carbohydrate    cell    detection    disease    alzheimer    spreading    candidates    nature    character    biology    molecular    internalized    genetics    arrestad    prevention    enzymology    seeding    interactomics    internationally    phosphorylation    kits    experts    chemistry    beta    demonstration    proposes    joint    central    technologies    triggered    tau    class    links   

Project "ArrestAD" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE PARIS XII VAL DE MARNE 

Organization address
address: AVENUE DU GENERAL DE GAULLE 61
city: CRETEIL
postcode: 94010
website: www.univ-paris12.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://arrestad.wordpress.com/
 Total cost 3˙991˙096 €
 EC max contribution 3˙991˙096 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE PARIS XII VAL DE MARNE FR (CRETEIL) coordinator 891˙181.00
2    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) participant 579˙250.00
3    INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK PL (WARSZAWA) participant 518˙125.00
4    FUNDACION DE INVESTIGACION DEL CANCER DE LA UNIVERSIDAD DE SALAMANCA ES (SALAMANCA) participant 452˙375.00
5    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 400˙625.00
6    UNIVERSIDAD AUTONOMA DE BARCELONA ES (CERDANYOLA DEL VALLES) participant 394˙875.00
7    ASSISTANCE PUBLIQUE HOPITAUX DE PARIS FR (PARIS) participant 383˙540.00
8    SCREENCELL FR (SARCELLES) participant 371˙125.00

Map

 Project objective

ArrestAD proposes a novel and visionary thinking resulting from the demonstration of the central role of a particular heparan sulfate species at the intracellular level in neurons and in circulating cells in the molecular pathology of Alzheimer’s disease (AD). AD is a societal challenge for which there is neither prevention nor possible cure. Research in the field has long been refining classic concepts based on the aggregation of Aβ and tau through initial seeding and then spreading. Our vision is different and based on the demonstration that tau abnormal phosphorylation and aggregation is triggered by the interaction of tau with heparan sulfates internalized in neurons and circulating cells only in AD [UPEC R.1; P.1,2]. Based in this new concept, ArrestAD will establish links between AD genetics, disease hallmarks, and altered traffic and intracellular accumulation of heparan sulfates to generate new knowledge underpinning the development of new strategies for detection and treatment of AD. This will open to radically new technologies addressing two major objectives: 1) proving that specific and early diagnosis of AD is possible in circulating cells, and 2) demonstrating that a new class of drug candidates are able to preventing and/or arresting AD-neurodegeneration. To reach these objectives, ArrestAD brings together internationally recognized experts in AD clinics and diagnosis, in heparan sulfate biology, transcriptomics, interactomics, carbohydrate chemistry, enzymology, cell biology, animal experimentation with AD models, and a SME specialized in the development of diagnosis kits using circulating cells. The high-risk character of this joint science and technology research is offset by the multidisciplinary nature of the Consortium and the high socio-economic gain resulting from success. Based in this technology, we will build a diverse portfolio of future projects that will result in a long-term benefit for citizens, economy and society.

 Deliverables

List of deliverables.
Listing RNA and protein extracts from AD Documents, reports 2020-02-19 17:34:49
Data management Plan Open Research Data Pilot 2020-02-19 17:34:49
Dissemination and exploitation plan Documents, reports 2020-02-19 17:34:49
Cohorts description Documents, reports 2020-02-19 17:34:49
Website and Communication tools Websites, patent fillings, videos etc. 2020-02-19 17:34:48

Take a look to the deliverables list in detail:  detailed list of ArrestAD deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Oscar González-Velasco, Dulce Papy-García, Gael Le Douaron, José M. Sánchez-Santos, Javier De Las Rivas
Transcriptomic landscape, gene signatures and regulatory profile of aging in the human brain
published pages: 194491, ISSN: 1874-9399, DOI: 10.1016/j.bbagrm.2020.194491
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2020-03-11
2019 Neil M. Kershaw, Dominic P. Byrne, Hollie Parsons, Neil G. Berry, David G. Fernig, Patrick A. Eyers, Richard Cosstick
Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors
published pages: 32165-32173, ISSN: 2046-2069, DOI: 10.1039/c9ra07567d
RSC Advances 9/55 2020-02-19
2019 Bui TP, Li Y, Ngamlert P, Nunes QM, Wilkinson MC and Fernig DG
Selective labelling of arginine residues engaged in binding sulfated glycosaminoglycans
published pages: , ISSN: , DOI: 10.1101/574947
bioRxiv 2020-02-19
2017 C. Vera, J.A. Álvarez-Orozco, A. Maïza, S. Chantepie, R.N. Chehín, M.O. Ouidja, D. Papy-Garcia
[Heparan sulphates, amyloidosis and neurodegeneration]
published pages: 457-468, ISSN: 0210-0010, DOI:
Revista de neurologia 65 2020-02-19
2018 Joanna Wojsiat, Katarzyna Marta Zoltowska, Katarzyna Laskowska-Kaszub, Urszula Wojda
Oxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects
published pages: 1-16, ISSN: 1942-0900, DOI: 10.1155/2018/6435861
Oxidative Medicine and Cellular Longevity 2018 2020-02-19
2017 Toin H. van Kuppevelt, Arie Oosterhof, Elly M. M. Versteeg, Emina Podhumljak, Els M. A. van de Westerlo, Willeke F. Daamen
Sequencing of glycosaminoglycans with potential to interrogate sequence-specific interactions
published pages: 14785, ISSN: 2045-2322, DOI: 10.1038/s41598-017-15009-0
Scientific Reports 7/1 2020-02-19
2018 Dominic P. Byrne, Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E. Eyers, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers
New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors
published pages: 2435-2455, ISSN: 0264-6021, DOI: 10.1042/bcj20180266
Biochemical Journal 475/15 2020-02-19
2018 Dominic P. Byrne, Yong Li, Krithika Ramakrishnan, Igor L. Barsukov, Edwin A. Yates, Claire E. Eyers, Dulcé Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers
New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors
published pages: 2417-2433, ISSN: 0264-6021, DOI: 10.1042/BCJ20180265
Biochemical Journal 475/15 2020-02-19
2019 Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane Maïza, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garcia
Glycosaminoglycans from Alzheimer’s disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau
published pages: e0209573, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0209573
PLOS ONE 14/1 2020-02-19
2018 Auriane Maïza, Sandrine Chantepie, Cecilia Vera, Alexandre Fifre, Minh Bao Huynh, Olivier Stettler, Mohand Ouidir Ouidja, Dulce Papy‐Garcia
The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration
published pages: 3806-3818, ISSN: 0014-5793, DOI: 10.1002/1873-3468.13082
FEBS Letters 592/23 2020-02-19
2019 Siranjeevi Nagaraj, Katarzyna Marta Zoltowska, Katarzyna Laskowska-Kaszub, Urszula Wojda
microRNA diagnostic panel for Alzheimer’s disease and epigenetic trade-off between neurodegeneration and cancer
published pages: 125-143, ISSN: 1568-1637, DOI: 10.1016/j.arr.2018.10.008
Ageing Research Reviews 49 2020-02-19
2018 Raquel Baeta-Corral, Rafael Castro-Fuentes, Lydia Giménez-Llort
Sexual Dimorphism in the Behavioral Responses and the Immunoendocrine Status in d-Galactose-Induced Aging
published pages: 1147-1157, ISSN: 1079-5006, DOI: 10.1093/gerona/gly031
The Journals of Gerontology: Series A 73/9 2020-02-19

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