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Identification and characterization of enteric nervous system stem cells

Total Cost €


EC-Contrib. €






 IDENSTEM project word cloud

Explore the words cloud of the IDENSTEM project. It provides you a very rough idea of what is the project "IDENSTEM" about.

organism    disease    waste    intestinal    tract    balanced    subpopulation    notch    debilitating    water    barrier    removal    epithelial    preliminary    glial    stem    contributions    inflammation    physiology    underpin    collection    nutrient    inflammatory    molecular    mouse    hes5    population    experimental    window    deficits    digestive    cells    acquired    proliferation    communication    signalling    gut    hirschsprung    little    brain    congenital    injury    model    strategies    axis    ens    microbiota    neurogenic    data    enscs    central    understand    gastrointestinal    cellular    identity    circuitry    enteric    serves    normal    tissues    steady    developmental    regulate    megacolon    harbours    suggest    interacting    disorders    wish    collectively    independently    mechanisms    idenstem    neurons    rate    integrity    neurogastroenterology    fundamental    maintaining    human    immune    sensory    bowel    critical    input    function    despite    homeostasis    neural    tissue    plays    exhibit    expressing    multiple    contribution    therapeutic    actively    nervous    components    health    undergo   

Project "IDENSTEM" data sheet

The following table provides information about the project.


Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The digestive system is essential for water and nutrient uptake, waste removal and serves as a sensory system providing information to the central nervous system via the gut-brain communication axis. The gastrointestinal tract harbours the largest collection of neurons and glial cells collectively known as the enteric nervous system (ENS) and regulate digestive physiology independently of brain input. Intestinal function and homeostasis depend on the integrated and balanced activity of multiple gut tissues,in which, the ENS plays a critical role by actively interacting with the intestinal immune system, the epithelial barrier and microbiota. Developmental deficits or acquired disorders in any of these tissue components can result in debilitating gastrointestinal conditions, such as Hirschsprung disease (congenital megacolon) or inflammatory bowel disease. Despite critical contributions of the ENS to digestive physiology and intestinal homeostasis, very little is known about the cellular mechanisms that underpin its function at steady state conditions or in response to injury. IDENSTEM will address the identity and properties of ENS neural stem cells (ENSCs) using the mouse as an experimental model organism. Preliminary data suggest that a subpopulation of enteric glial cells expressing the Notch signalling target Hes5, undergo low rate proliferation and exhibit neurogenic potential. In this proposal, we aim to identify and characterize the cellular and molecular properties of this population. We wish to understand their contribution in maintaining ENS integrity under normal conditions or in response to injury/disease. These studies will advance fundamental neurogastroenterology and the development of novel therapeutic strategies for various gut disorders. Furthermore, they will provide insight into ENS contributions to the gut tissue circuitry and in intestinal inflammation. IDENSTEM will open a new window of knowledge to improve human health.

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The information about "IDENSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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