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IDENSTEM SIGNED

Identification and characterization of enteric nervous system stem cells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IDENSTEM project word cloud

Explore the words cloud of the IDENSTEM project. It provides you a very rough idea of what is the project "IDENSTEM" about.

interacting    deficits    intestinal    harbours    strategies    identity    megacolon    subpopulation    organism    developmental    collectively    function    disease    normal    enteric    model    actively    neurogenic    homeostasis    microbiota    idenstem    despite    neurons    tissues    multiple    window    regulate    tract    waste    nervous    maintaining    collection    balanced    independently    serves    hirschsprung    water    axis    acquired    understand    neural    contributions    health    integrity    notch    gut    barrier    little    bowel    physiology    hes5    underpin    congenital    steady    digestive    communication    data    inflammation    critical    nutrient    exhibit    components    plays    enscs    mouse    epithelial    stem    immune    neurogastroenterology    cellular    glial    circuitry    expressing    mechanisms    preliminary    injury    wish    input    rate    molecular    signalling    contribution    therapeutic    population    brain    central    tissue    removal    disorders    debilitating    sensory    inflammatory    fundamental    suggest    cells    ens    gastrointestinal    human    experimental    undergo    proliferation   

Project "IDENSTEM" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 212˙933.00

Map

 Project objective

The digestive system is essential for water and nutrient uptake, waste removal and serves as a sensory system providing information to the central nervous system via the gut-brain communication axis. The gastrointestinal tract harbours the largest collection of neurons and glial cells collectively known as the enteric nervous system (ENS) and regulate digestive physiology independently of brain input. Intestinal function and homeostasis depend on the integrated and balanced activity of multiple gut tissues,in which, the ENS plays a critical role by actively interacting with the intestinal immune system, the epithelial barrier and microbiota. Developmental deficits or acquired disorders in any of these tissue components can result in debilitating gastrointestinal conditions, such as Hirschsprung disease (congenital megacolon) or inflammatory bowel disease. Despite critical contributions of the ENS to digestive physiology and intestinal homeostasis, very little is known about the cellular mechanisms that underpin its function at steady state conditions or in response to injury. IDENSTEM will address the identity and properties of ENS neural stem cells (ENSCs) using the mouse as an experimental model organism. Preliminary data suggest that a subpopulation of enteric glial cells expressing the Notch signalling target Hes5, undergo low rate proliferation and exhibit neurogenic potential. In this proposal, we aim to identify and characterize the cellular and molecular properties of this population. We wish to understand their contribution in maintaining ENS integrity under normal conditions or in response to injury/disease. These studies will advance fundamental neurogastroenterology and the development of novel therapeutic strategies for various gut disorders. Furthermore, they will provide insight into ENS contributions to the gut tissue circuitry and in intestinal inflammation. IDENSTEM will open a new window of knowledge to improve human health.

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The information about "IDENSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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