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Identification and characterization of enteric nervous system stem cells

Total Cost €


EC-Contrib. €






 IDENSTEM project word cloud

Explore the words cloud of the IDENSTEM project. It provides you a very rough idea of what is the project "IDENSTEM" about.

despite    tissues    collection    little    communication    homeostasis    debilitating    microbiota    megacolon    water    congenital    function    deficits    multiple    hirschsprung    wish    notch    disorders    model    disease    therapeutic    neurogastroenterology    actively    regulate    normal    inflammation    balanced    ens    underpin    fundamental    experimental    enteric    molecular    nutrient    data    cellular    physiology    central    integrity    contributions    identity    signalling    mechanisms    stem    digestive    axis    enscs    cells    undergo    rate    plays    mouse    suggest    epithelial    waste    tract    understand    steady    proliferation    strategies    organism    gastrointestinal    neurogenic    input    sensory    developmental    bowel    subpopulation    intestinal    serves    neurons    window    brain    nervous    inflammatory    population    immune    tissue    neural    components    preliminary    interacting    harbours    circuitry    barrier    contribution    independently    removal    injury    idenstem    gut    health    expressing    hes5    glial    human    exhibit    maintaining    critical    collectively    acquired   

Project "IDENSTEM" data sheet

The following table provides information about the project.


Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The digestive system is essential for water and nutrient uptake, waste removal and serves as a sensory system providing information to the central nervous system via the gut-brain communication axis. The gastrointestinal tract harbours the largest collection of neurons and glial cells collectively known as the enteric nervous system (ENS) and regulate digestive physiology independently of brain input. Intestinal function and homeostasis depend on the integrated and balanced activity of multiple gut tissues,in which, the ENS plays a critical role by actively interacting with the intestinal immune system, the epithelial barrier and microbiota. Developmental deficits or acquired disorders in any of these tissue components can result in debilitating gastrointestinal conditions, such as Hirschsprung disease (congenital megacolon) or inflammatory bowel disease. Despite critical contributions of the ENS to digestive physiology and intestinal homeostasis, very little is known about the cellular mechanisms that underpin its function at steady state conditions or in response to injury. IDENSTEM will address the identity and properties of ENS neural stem cells (ENSCs) using the mouse as an experimental model organism. Preliminary data suggest that a subpopulation of enteric glial cells expressing the Notch signalling target Hes5, undergo low rate proliferation and exhibit neurogenic potential. In this proposal, we aim to identify and characterize the cellular and molecular properties of this population. We wish to understand their contribution in maintaining ENS integrity under normal conditions or in response to injury/disease. These studies will advance fundamental neurogastroenterology and the development of novel therapeutic strategies for various gut disorders. Furthermore, they will provide insight into ENS contributions to the gut tissue circuitry and in intestinal inflammation. IDENSTEM will open a new window of knowledge to improve human health.

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The information about "IDENSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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