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IDENSTEM SIGNED

Identification and characterization of enteric nervous system stem cells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IDENSTEM project word cloud

Explore the words cloud of the IDENSTEM project. It provides you a very rough idea of what is the project "IDENSTEM" about.

enscs    tissue    actively    mouse    axis    disease    suggest    barrier    data    population    circuitry    water    microbiota    idenstem    molecular    megacolon    removal    balanced    collectively    bowel    communication    maintaining    digestive    immune    neurogenic    model    normal    gut    components    little    despite    fundamental    nervous    hes5    collection    expressing    inflammation    epithelial    gastrointestinal    human    identity    exhibit    experimental    cellular    input    nutrient    steady    regulate    contributions    injury    tissues    acquired    developmental    disorders    neurons    homeostasis    central    preliminary    intestinal    independently    multiple    understand    sensory    neural    hirschsprung    subpopulation    plays    proliferation    health    cells    harbours    organism    stem    waste    interacting    congenital    contribution    deficits    tract    debilitating    window    enteric    rate    wish    undergo    therapeutic    ens    critical    neurogastroenterology    mechanisms    brain    integrity    notch    strategies    serves    signalling    glial    inflammatory    function    physiology    underpin   

Project "IDENSTEM" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 212˙933.00

Map

 Project objective

The digestive system is essential for water and nutrient uptake, waste removal and serves as a sensory system providing information to the central nervous system via the gut-brain communication axis. The gastrointestinal tract harbours the largest collection of neurons and glial cells collectively known as the enteric nervous system (ENS) and regulate digestive physiology independently of brain input. Intestinal function and homeostasis depend on the integrated and balanced activity of multiple gut tissues,in which, the ENS plays a critical role by actively interacting with the intestinal immune system, the epithelial barrier and microbiota. Developmental deficits or acquired disorders in any of these tissue components can result in debilitating gastrointestinal conditions, such as Hirschsprung disease (congenital megacolon) or inflammatory bowel disease. Despite critical contributions of the ENS to digestive physiology and intestinal homeostasis, very little is known about the cellular mechanisms that underpin its function at steady state conditions or in response to injury. IDENSTEM will address the identity and properties of ENS neural stem cells (ENSCs) using the mouse as an experimental model organism. Preliminary data suggest that a subpopulation of enteric glial cells expressing the Notch signalling target Hes5, undergo low rate proliferation and exhibit neurogenic potential. In this proposal, we aim to identify and characterize the cellular and molecular properties of this population. We wish to understand their contribution in maintaining ENS integrity under normal conditions or in response to injury/disease. These studies will advance fundamental neurogastroenterology and the development of novel therapeutic strategies for various gut disorders. Furthermore, they will provide insight into ENS contributions to the gut tissue circuitry and in intestinal inflammation. IDENSTEM will open a new window of knowledge to improve human health.

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The information about "IDENSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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