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IDENSTEM SIGNED

Identification and characterization of enteric nervous system stem cells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IDENSTEM project word cloud

Explore the words cloud of the IDENSTEM project. It provides you a very rough idea of what is the project "IDENSTEM" about.

epithelial    sensory    molecular    organism    enscs    population    waste    plays    removal    inflammatory    tract    little    circuitry    human    mechanisms    hirschsprung    cellular    megacolon    barrier    congenital    harbours    expressing    neurons    experimental    injury    neurogastroenterology    gut    water    identity    contributions    despite    critical    homeostasis    immune    serves    stem    collection    digestive    strategies    nutrient    tissues    ens    debilitating    steady    underpin    central    function    intestinal    enteric    brain    contribution    deficits    tissue    regulate    fundamental    independently    health    acquired    data    cells    hes5    input    nervous    suggest    integrity    mouse    physiology    undergo    neurogenic    collectively    balanced    interacting    inflammation    gastrointestinal    preliminary    glial    multiple    components    therapeutic    disease    axis    maintaining    communication    rate    proliferation    notch    microbiota    developmental    model    normal    actively    idenstem    bowel    subpopulation    exhibit    understand    signalling    neural    window    disorders    wish   

Project "IDENSTEM" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 212˙933.00

Map

 Project objective

The digestive system is essential for water and nutrient uptake, waste removal and serves as a sensory system providing information to the central nervous system via the gut-brain communication axis. The gastrointestinal tract harbours the largest collection of neurons and glial cells collectively known as the enteric nervous system (ENS) and regulate digestive physiology independently of brain input. Intestinal function and homeostasis depend on the integrated and balanced activity of multiple gut tissues,in which, the ENS plays a critical role by actively interacting with the intestinal immune system, the epithelial barrier and microbiota. Developmental deficits or acquired disorders in any of these tissue components can result in debilitating gastrointestinal conditions, such as Hirschsprung disease (congenital megacolon) or inflammatory bowel disease. Despite critical contributions of the ENS to digestive physiology and intestinal homeostasis, very little is known about the cellular mechanisms that underpin its function at steady state conditions or in response to injury. IDENSTEM will address the identity and properties of ENS neural stem cells (ENSCs) using the mouse as an experimental model organism. Preliminary data suggest that a subpopulation of enteric glial cells expressing the Notch signalling target Hes5, undergo low rate proliferation and exhibit neurogenic potential. In this proposal, we aim to identify and characterize the cellular and molecular properties of this population. We wish to understand their contribution in maintaining ENS integrity under normal conditions or in response to injury/disease. These studies will advance fundamental neurogastroenterology and the development of novel therapeutic strategies for various gut disorders. Furthermore, they will provide insight into ENS contributions to the gut tissue circuitry and in intestinal inflammation. IDENSTEM will open a new window of knowledge to improve human health.

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The information about "IDENSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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