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CHEMO-RISK SIGNED

Chemometers for in situ risk assessment of mixtures of pollutants

Total Cost €

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EC-Contrib. €

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Partnership

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 CHEMO-RISK project word cloud

Explore the words cloud of the CHEMO-RISK project. It provides you a very rough idea of what is the project "CHEMO-RISK" about.

media    humans    chemicals    disruption    enrichment    procedure    eyeglass    efforts    items    degree    lc    lacks    reactive    profiles    difficult    polymer    disregards    analogously    innovation    exposure    biota    combining    endocrine    chemical    assessment    broad    reporter    trigger    equilibrated    yields    ecosystem    thermometer    aquatic    effect    replace    toxic    paradigm    nose    environment    extrapolate    ignores    functions    invasive    surroundings    tackled    environmental    modes    scientifically    characterise    stress    mixtures    unacceptable    questions    bioassays    turn    drive    mixture    chemometer    health    organism    life    basis    elicit    gene    orbitrap    chemometers    risk    pads    human    adaptive    genotoxicity    integrates    indicates    breaking    single    temperature    notch    specificity    acceptable    sites    action    site    thermodynamic    chemo    provides    baseline    biouptake    gc    pollutant    sampling    distribute    unified    extracts    partitioning    cell    everyday    toxicity    instead    pollutants    sound    distinguishing    bioavailability   

Project "CHEMO-RISK" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ 

Organization address
address: PERMOSERSTRASSE 15
city: LEIPZIG
postcode: 4318
website: www.ufz.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙496˙030 €
 EC max contribution 1˙496˙030 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ DE (LEIPZIG) coordinator 1˙496˙030.00

Map

 Project objective

CHEMO-RISK aims for a novel scientifically sound chemical risk assessment paradigm that integrates exposure and effect assessment of a broad range of chemicals into a single procedure and provides information relevant to ecosystem and human health. The key innovation is polymer “chemometers” that will be equilibrated with their surroundings and deliver information on the pollutant’s chemical activity in the environment, biota, and humans. A chemometer functions analogously to a thermometer, but instead of the temperature, it yields a measure of chemical activity. Chemical activity in turn indicates the thermodynamic potential for, e.g., partitioning, biouptake and toxicity. CHEMO-RISK aims at breaking the current paradigm in environmental risk assessment of single chemicals that disregards bioavailability, ignores mixture effects, lacks site-specificity and is difficult to extrapolate to human health. The chemometer extracts will be investigated using top-notch (a) GC and LC/Orbitrap chemical analysis to characterise the pollutant mixtures and (b) cell-based reporter gene bioassays to determine mixture effects covering baseline toxicity, specific (e.g., endocrine disruption) and reactive (e.g., genotoxicity) modes of toxic action and adaptive stress responses. Within CHEMO-RISK, the following important research questions will be tackled: (A) Which processes drive the enrichment of pollutants in aquatic biota on a thermodynamic basis? (B) How do pollutants distribute within an organism, and which effects do they elicit at the key target sites? (C) Can we apply everyday-life items such as eyeglass-nose pads to replace invasive sampling in human health risk assessment? (D) To which degree can non-target analysis of chemometer extracts explain the observed toxicity profiles across media? By combining all these research efforts, CHEMO-RISK will provide a unified risk assessment paradigm with risk-based trigger values distinguishing acceptable from unacceptable effects.

 Publications

year authors and title journal last update
List of publications.
2020 Eva B. Reiter, Annika Jahnke, Maria König, Ursula Siebert, Beate I. Escher
Influence of Co-Dosed Lipids from Biota Extracts on the Availability of Chemicals in In Vitro Cell-Based Bioassays
published pages: , ISSN: 0013-936X, DOI: 10.1021/acs.est.9b07850
Environmental Science & Technology 2020-04-03
2019 Elisa Rojo-Nieto, Melis Muz, Jan Koschorreck, Heinz Rüdel, Annika Jahnke
Passive equilibrium sampling of hydrophobic organic compounds in homogenised fish tissues of low lipid content
published pages: 501-504, ISSN: 0045-6535, DOI: 10.1016/j.chemosphere.2018.12.134
Chemosphere 220 2019-12-16

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