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Chemometers for in situ risk assessment of mixtures of pollutants

Total Cost €


EC-Contrib. €






 CHEMO-RISK project word cloud

Explore the words cloud of the CHEMO-RISK project. It provides you a very rough idea of what is the project "CHEMO-RISK" about.

disruption    toxic    surroundings    temperature    paradigm    everyday    ignores    biouptake    lacks    specificity    efforts    pollutants    functions    environment    innovation    assessment    profiles    eyeglass    thermodynamic    chemometers    chemicals    trigger    partitioning    unified    polymer    invasive    media    thermometer    bioavailability    sites    baseline    pollutant    equilibrated    basis    organism    difficult    provides    tackled    questions    reporter    replace    unacceptable    instead    mixtures    bioassays    distribute    degree    sound    notch    risk    cell    yields    adaptive    action    sampling    health    effect    acceptable    modes    chemometer    integrates    single    gc    breaking    turn    scientifically    endocrine    analogously    ecosystem    biota    characterise    orbitrap    reactive    human    procedure    disregards    extrapolate    toxicity    life    nose    environmental    exposure    stress    site    combining    chemo    gene    elicit    mixture    enrichment    lc    distinguishing    broad    genotoxicity    items    pads    drive    aquatic    chemical    humans    indicates    extracts   

Project "CHEMO-RISK" data sheet

The following table provides information about the project.


Organization address
postcode: 4318

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙496˙030 €
 EC max contribution 1˙496˙030 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

CHEMO-RISK aims for a novel scientifically sound chemical risk assessment paradigm that integrates exposure and effect assessment of a broad range of chemicals into a single procedure and provides information relevant to ecosystem and human health. The key innovation is polymer “chemometers” that will be equilibrated with their surroundings and deliver information on the pollutant’s chemical activity in the environment, biota, and humans. A chemometer functions analogously to a thermometer, but instead of the temperature, it yields a measure of chemical activity. Chemical activity in turn indicates the thermodynamic potential for, e.g., partitioning, biouptake and toxicity. CHEMO-RISK aims at breaking the current paradigm in environmental risk assessment of single chemicals that disregards bioavailability, ignores mixture effects, lacks site-specificity and is difficult to extrapolate to human health. The chemometer extracts will be investigated using top-notch (a) GC and LC/Orbitrap chemical analysis to characterise the pollutant mixtures and (b) cell-based reporter gene bioassays to determine mixture effects covering baseline toxicity, specific (e.g., endocrine disruption) and reactive (e.g., genotoxicity) modes of toxic action and adaptive stress responses. Within CHEMO-RISK, the following important research questions will be tackled: (A) Which processes drive the enrichment of pollutants in aquatic biota on a thermodynamic basis? (B) How do pollutants distribute within an organism, and which effects do they elicit at the key target sites? (C) Can we apply everyday-life items such as eyeglass-nose pads to replace invasive sampling in human health risk assessment? (D) To which degree can non-target analysis of chemometer extracts explain the observed toxicity profiles across media? By combining all these research efforts, CHEMO-RISK will provide a unified risk assessment paradigm with risk-based trigger values distinguishing acceptable from unacceptable effects.


year authors and title journal last update
List of publications.
2020 Eva B. Reiter, Annika Jahnke, Maria König, Ursula Siebert, Beate I. Escher
Influence of Co-Dosed Lipids from Biota Extracts on the Availability of Chemicals in In Vitro Cell-Based Bioassays
published pages: , ISSN: 0013-936X, DOI: 10.1021/acs.est.9b07850
Environmental Science & Technology 2020-04-03
2019 Elisa Rojo-Nieto, Melis Muz, Jan Koschorreck, Heinz Rüdel, Annika Jahnke
Passive equilibrium sampling of hydrophobic organic compounds in homogenised fish tissues of low lipid content
published pages: 501-504, ISSN: 0045-6535, DOI: 10.1016/j.chemosphere.2018.12.134
Chemosphere 220 2019-12-16

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