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Chemometers for in situ risk assessment of mixtures of pollutants

Total Cost €


EC-Contrib. €






 CHEMO-RISK project word cloud

Explore the words cloud of the CHEMO-RISK project. It provides you a very rough idea of what is the project "CHEMO-RISK" about.

toxicity    temperature    pollutant    toxic    efforts    pads    ignores    human    equilibrated    partitioning    polymer    scientifically    single    questions    replace    reporter    surroundings    unacceptable    items    orbitrap    chemometers    disruption    innovation    extracts    biouptake    paradigm    effect    assessment    drive    health    difficult    extrapolate    stress    lc    pollutants    thermodynamic    mixtures    functions    gene    degree    integrates    trigger    specificity    analogously    life    biota    sound    notch    sites    endocrine    disregards    eyeglass    humans    elicit    exposure    chemical    acceptable    unified    ecosystem    baseline    mixture    reactive    combining    procedure    distribute    lacks    profiles    instead    basis    site    bioavailability    media    risk    broad    turn    adaptive    nose    aquatic    modes    provides    chemicals    thermometer    breaking    characterise    invasive    tackled    organism    genotoxicity    environment    enrichment    sampling    everyday    cell    distinguishing    gc    indicates    chemometer    bioassays    action    environmental    chemo    yields   

Project "CHEMO-RISK" data sheet

The following table provides information about the project.


Organization address
postcode: 4318

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙496˙030 €
 EC max contribution 1˙496˙030 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

CHEMO-RISK aims for a novel scientifically sound chemical risk assessment paradigm that integrates exposure and effect assessment of a broad range of chemicals into a single procedure and provides information relevant to ecosystem and human health. The key innovation is polymer “chemometers” that will be equilibrated with their surroundings and deliver information on the pollutant’s chemical activity in the environment, biota, and humans. A chemometer functions analogously to a thermometer, but instead of the temperature, it yields a measure of chemical activity. Chemical activity in turn indicates the thermodynamic potential for, e.g., partitioning, biouptake and toxicity. CHEMO-RISK aims at breaking the current paradigm in environmental risk assessment of single chemicals that disregards bioavailability, ignores mixture effects, lacks site-specificity and is difficult to extrapolate to human health. The chemometer extracts will be investigated using top-notch (a) GC and LC/Orbitrap chemical analysis to characterise the pollutant mixtures and (b) cell-based reporter gene bioassays to determine mixture effects covering baseline toxicity, specific (e.g., endocrine disruption) and reactive (e.g., genotoxicity) modes of toxic action and adaptive stress responses. Within CHEMO-RISK, the following important research questions will be tackled: (A) Which processes drive the enrichment of pollutants in aquatic biota on a thermodynamic basis? (B) How do pollutants distribute within an organism, and which effects do they elicit at the key target sites? (C) Can we apply everyday-life items such as eyeglass-nose pads to replace invasive sampling in human health risk assessment? (D) To which degree can non-target analysis of chemometer extracts explain the observed toxicity profiles across media? By combining all these research efforts, CHEMO-RISK will provide a unified risk assessment paradigm with risk-based trigger values distinguishing acceptable from unacceptable effects.


year authors and title journal last update
List of publications.
2020 Eva B. Reiter, Annika Jahnke, Maria König, Ursula Siebert, Beate I. Escher
Influence of Co-Dosed Lipids from Biota Extracts on the Availability of Chemicals in In Vitro Cell-Based Bioassays
published pages: , ISSN: 0013-936X, DOI: 10.1021/acs.est.9b07850
Environmental Science & Technology 2020-04-03
2019 Elisa Rojo-Nieto, Melis Muz, Jan Koschorreck, Heinz Rüdel, Annika Jahnke
Passive equilibrium sampling of hydrophobic organic compounds in homogenised fish tissues of low lipid content
published pages: 501-504, ISSN: 0045-6535, DOI: 10.1016/j.chemosphere.2018.12.134
Chemosphere 220 2019-12-16

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