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Spontaneous ZeBrain SIGNED

Whole-brain dynamics underlying self-generated behaviour

Total Cost €

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EC-Contrib. €

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Project "Spontaneous ZeBrain" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙997˙360 €
 EC max contribution 1˙997˙360 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙997˙360.00

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 Project objective

The first behavioural theories conceived the organism as primarily driven by external sensory stimuli. However, the energy associated with momentary demands of the environment represent ~1% of the brain's total energy budget, implying that the intrinsic activity represents a major aspect of the brain's function. Indeed, more recent theories such as cognitivism and embodiment describe the organisms as capable of generating complex behaviours emerging from the brain's intrinsic dynamics. Past and current studies that investigated the neuronal basis self-generated behaviours mainly focus on the readiness potential (RP) signal, a build-up ramping activity in the premotor cortex, occurring ~ 2 sec before the movement's onset. However, the neuronal mechanisms underlying the generation of self-generated behaviours (how RPs are generated), the involvement of other regions, and how the brain codes the impending movements (activity predictive of the onset and type of movement), still remain poorly understood. The combination of light-sheet microscopy, optogenetics, and the zebrafish larva model enables monitoring whole-brain dynamics in an intact behaving vertebrate. Moreover, the diverse yet limited and well described repertoire of motor behaviours will enable to perform experiments in more natural unconstrained conditions, in comparison to previous studies, which were structured in trials and limited to one or two behavioural choices. These advantages will allow us to go beyond the current state-of-the-art in the field. More specifically, we propose to investigate the following specific aims:

1) Whole-brain dynamics basis and mechanisms underlying self-generated behaviours.

2) A comparison between the neuronal pathways underlying the initiation of self-generated and sensory induced behaviours.

3) The internal and external modulation of self-generated behaviours.

 Publications

year authors and title journal last update
List of publications.
2019 Martin Privat, Sebastián A. Romano, Thomas Pietri, Adrien Jouary, Jonathan Boulanger-Weill, Nicolas Elbaz, Auriane Duchemin, Daphne Soares, Germán Sumbre
Sensorimotor Transformations in the Zebrafish Auditory System
published pages: , ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.10.020
Current Biology 2019-12-16
2018 Adrián Ponce-Alvarez, Adrien Jouary, Martin Privat, Gustavo Deco, Germán Sumbre
Whole-Brain Neuronal Activity Displays Crackling Noise Dynamics
published pages: 1446-1459.e6, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.10.045
Neuron 100/6 2019-09-02
2018 Emiliano Marachlian, Lilach Avitan, Geoffrey J. Goodhill, Germán Sumbre
Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum
published pages: , ISSN: 1662-5110, DOI: 10.3389/fncir.2018.00046
Frontiers in Neural Circuits 12 2019-09-02

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The information about "SPONTANEOUS ZEBRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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