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FungArth SIGNED

Role of intestinal fungal communities in arthritic pathology

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "FungArth" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 160˙800.00

Map

 Project objective

The human body is in constant interaction with a complex group of micro-organisms like bacteria, viruses and fungi which populate various body surfaces like our skin, lungs and gut. These organisms generally don’t pose a threat to the host but in contrary have many beneficial functions like stimulating the correct development of our immune system. Until now, research has mainly focused on bacteria, while fungi have largely been overlooked. Enteric fungi represent a significant part of the intestinal microbiota, but their role in human health and disease is poorly characterized. Spondyloarthritis (SpA) is a common immune pathology which causes severe spine and joint inflammation and the lab of Prof. Dirk Elewaut was the first to show a mechanistic link between spondyloarthritis and intestinal inflammation. Interestingly, anti-fungal immune reponses require Th17 (specific T lymphocytes) activation, an immune arm commonly hyperactivated in arthritic disease. We therefore hypothesize that abberrant antifungal immune responses may be contributing to arthritic pathology. Alternatively, homeostatic fungal-host interactions may be important for both mucosal and systemic immune homeostasis. With this research project, I propose to study in detail the contribution of naturally occurring intestinal fungi to health and SpA development in a multi- disciplinary manner, using elegant genetic mouse models of disease, state-of-the-art tools and technologies and clinical samples from SpA patients.

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The information about "FUNGARTH" are provided by the European Opendata Portal: CORDIS opendata.

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