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GLYCONHC

Exploiting carbohydrate/N-heterocyclic carbene hybrid complexes as innovative multifunctional oxidation catalysts with tailoring of weak interactions allowing for development of enzyme mimics

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GLYCONHC project word cloud

Explore the words cloud of the GLYCONHC project. It provides you a very rough idea of what is the project "GLYCONHC" about.

synergistic    explored    functional    metalloenzyme    literature    site    demonstrated    functionalised    nhc    probed    experimental    receptors    ligands    proteins    click    olefins    carbohydrate    classes    functionalising    carbohydrates    complementing    host    versatile    catalysts    proton    catalysis    catalytic    maturity    innovative    candidate    shuffling    alcohols    geometry    opportunity    groups    mobility    bonding    bind    hybrid    sites    matching    relationships    unknown    substrates    modular    breaking    vast    training    despite    biological    oxidative    compounds    heterocyclic    interdisciplinary    oxidation    synthesised    hydrogen    advantages    recognition    chemistry    purposes    nhcs    practically    mimics    group    accessible    amines    complexes    ir    carbenes    derivatives    interactions    turnover    beneficial    ru    pharmaceutically    chirality    enantioselectivity    synthetically    computational    benefit    structure    synthetic    possess    readiliy    receptor    molecular    combining    triazolylidine   

Project "GLYCONHC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://www.albrechtresearch.com
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 175˙419.00

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 Project objective

The key objective of this project is the development of innovative hybrid complexes for oxidative catalysis of pharmaceutically relevant functional groups (e.g. alcohols, amines, olefins), by combining the beneficial properties of triazolylidine N-heterocyclic carbenes and carbohydrates for synergistic catalysis and molecular recognition, ensuring site-specific bind making and breaking processes and tailored delivery. A range of novel carbohydrate-functionalised NHC complexes (e.g. with Ru(II) and Ir(III)) will be synthesised for these purposes and relationships between carbohydrate structure/geometry and catalytic activity probed, complementing experimental approaches with computational insight.

NHCs are synthetically versatile and have been demonstrated to have beneficial properties as ligands for catalysis. Triazolylidine NHCs are accessible via modular 'click' chemistry and readiliy functionalised, but not as widely explored as other classes of related compounds. Functionalising carbenes with carbohydrates is practically unknown in the literature despite many advantages such derivatives would possess, including well-defined geometry, rich hydrogen bonding and proton-shuffling interactions, recognition by biological receptors (providing the opportunity for developing NHC-based metalloenzyme mimics through interdisciplinary collaboration) and also chirality (allowing for enantioselectivity). The candidate has synthetic experience matching the project and will benefit from the specific training activities within the host group (who have vast NHC experience), mobility and change of topic to achieve research maturity.

Deliverables will include: 1) New catalysts for high-turnover oxidation of pharmaceutically relevant substrates 2) Innovative metalloenzyme mimics based on NHCs embedded in proteins' carbohydrate-receptor sites.

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The information about "GLYCONHC" are provided by the European Opendata Portal: CORDIS opendata.

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