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PrenatalStressOmics

Prenatal Stress Investigation in Cerebral Organoids: a multi-omics study at the level of single cells

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PrenatalStressOmics project word cloud

Explore the words cloud of the PrenatalStressOmics project. It provides you a very rough idea of what is the project "PrenatalStressOmics" about.

intervention    life    translation    models    stress    primary    powerful    transcriptomes    causing    exposure    model    precipitated    elucidating    molecular    mental    imperative    stressed    identification    stem    deconstruct    period    recapitulate    context    populations    clinical    gcs    pave    underwent    glucocorticoids    organoids    cohorts    organoid    types    mothers    risk    adversities    developmental    elevated    disease    mediators    culture    vulnerability    underpinnings    cell    epigenetic    illnesses    share    cerebral    longitudinal    human    animal    questions    mechanisms    dimensional    brain    tissues    psychiatric    disturbances    pregnancy    progress    hormone    organism    mediated    quantified    made    gc    disorders    epigenome    fine    25    individual    babies    placement    prenatal    strategies    population    transitions    unstressed    tissue    sequencing    techniques    basic    tools    expedite    neurobiology    cells    heterogeneity   

Project "PrenatalStressOmics" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 171˙460.00

Map

 Project objective

Mental illnesses affect 25% of the EU population and share increased disease risk through long-term changes to the stress hormone system. These are precipitated as adversities during early life, including the prenatal period. Given the role of stress in causing mental illnesses, it is imperative to learn more about the molecular mechanisms involved. Some progress has been made in elucidating the neurobiology of stress, but many questions cannot be addressed with current tools, which include animal models and 2-dimensional human cell culture systems. This proposal aims to establish 3-dimensional culture systems called cerebral organoids – stem-cell-derived tissues that recapitulate features of the human brain – as research models for developmental psychiatric disturbances. We will focus on glucocorticoids (GCs), some of the primary mediators of stress exposure on the organism, and use organoids as a model of early developing brain. Molecular mechanisms will be compared between ‘stressed’ and ‘unstressed’ conditions, by sequencing the transcriptomes of individual cells. Furthermore, since stress-related disorders are mediated through epigenetic mechanisms, the impact of elevated GC exposure on specific cell types in the cerebral organoid model will be quantified at the epigenome level. These novel and powerful techniques will allow us to deconstruct tissue heterogeneity, elucidating the fine molecular underpinnings of human vulnerability and response to stress. Comparing findings to evidence from longitudinal human cohorts of mothers and their babies who underwent stress during pregnancy will allow placement of findings into the clinical context. This research would pave the way for translation into clinical research, and expedite transitions from basic research to identification of at-risk populations, and even intervention strategies.

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The information about "PRENATALSTRESSOMICS" are provided by the European Opendata Portal: CORDIS opendata.

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