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PrenatalStressOmics

Prenatal Stress Investigation in Cerebral Organoids: a multi-omics study at the level of single cells

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PrenatalStressOmics project word cloud

Explore the words cloud of the PrenatalStressOmics project. It provides you a very rough idea of what is the project "PrenatalStressOmics" about.

glucocorticoids    stem    transcriptomes    period    heterogeneity    powerful    placement    cerebral    molecular    brain    mediators    elucidating    tissue    organism    precipitated    illnesses    underpinnings    translation    life    share    longitudinal    primary    stressed    expedite    cell    made    deconstruct    individual    dimensional    techniques    gcs    prenatal    epigenetic    mediated    models    basic    organoids    quantified    mothers    imperative    hormone    identification    clinical    adversities    recapitulate    progress    gc    epigenome    culture    questions    risk    cohorts    babies    types    pregnancy    causing    tools    unstressed    intervention    vulnerability    organoid    strategies    mental    fine    neurobiology    disease    mechanisms    context    psychiatric    sequencing    transitions    populations    animal    disturbances    tissues    disorders    25    underwent    stress    pave    elevated    model    cells    exposure    population    developmental    human   

Project "PrenatalStressOmics" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 171˙460.00

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 Project objective

Mental illnesses affect 25% of the EU population and share increased disease risk through long-term changes to the stress hormone system. These are precipitated as adversities during early life, including the prenatal period. Given the role of stress in causing mental illnesses, it is imperative to learn more about the molecular mechanisms involved. Some progress has been made in elucidating the neurobiology of stress, but many questions cannot be addressed with current tools, which include animal models and 2-dimensional human cell culture systems. This proposal aims to establish 3-dimensional culture systems called cerebral organoids – stem-cell-derived tissues that recapitulate features of the human brain – as research models for developmental psychiatric disturbances. We will focus on glucocorticoids (GCs), some of the primary mediators of stress exposure on the organism, and use organoids as a model of early developing brain. Molecular mechanisms will be compared between ‘stressed’ and ‘unstressed’ conditions, by sequencing the transcriptomes of individual cells. Furthermore, since stress-related disorders are mediated through epigenetic mechanisms, the impact of elevated GC exposure on specific cell types in the cerebral organoid model will be quantified at the epigenome level. These novel and powerful techniques will allow us to deconstruct tissue heterogeneity, elucidating the fine molecular underpinnings of human vulnerability and response to stress. Comparing findings to evidence from longitudinal human cohorts of mothers and their babies who underwent stress during pregnancy will allow placement of findings into the clinical context. This research would pave the way for translation into clinical research, and expedite transitions from basic research to identification of at-risk populations, and even intervention strategies.

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The information about "PRENATALSTRESSOMICS" are provided by the European Opendata Portal: CORDIS opendata.

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