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PrenatalStressOmics

Prenatal Stress Investigation in Cerebral Organoids: a multi-omics study at the level of single cells

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PrenatalStressOmics project word cloud

Explore the words cloud of the PrenatalStressOmics project. It provides you a very rough idea of what is the project "PrenatalStressOmics" about.

quantified    gc    elucidating    cerebral    human    sequencing    pregnancy    deconstruct    stress    mothers    animal    mechanisms    share    powerful    culture    neurobiology    tissue    recapitulate    placement    techniques    expedite    mental    transitions    hormone    model    disease    adversities    prenatal    pave    stem    heterogeneity    glucocorticoids    tissues    elevated    models    risk    gcs    mediated    life    made    cells    clinical    progress    tools    cell    25    epigenetic    mediators    intervention    developmental    illnesses    stressed    imperative    basic    exposure    epigenome    transcriptomes    identification    underpinnings    populations    translation    vulnerability    precipitated    molecular    individual    babies    types    organoid    dimensional    population    underwent    disturbances    brain    fine    period    strategies    disorders    questions    organoids    context    longitudinal    unstressed    causing    organism    psychiatric    cohorts    primary   

Project "PrenatalStressOmics" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 171˙460.00

Map

 Project objective

Mental illnesses affect 25% of the EU population and share increased disease risk through long-term changes to the stress hormone system. These are precipitated as adversities during early life, including the prenatal period. Given the role of stress in causing mental illnesses, it is imperative to learn more about the molecular mechanisms involved. Some progress has been made in elucidating the neurobiology of stress, but many questions cannot be addressed with current tools, which include animal models and 2-dimensional human cell culture systems. This proposal aims to establish 3-dimensional culture systems called cerebral organoids – stem-cell-derived tissues that recapitulate features of the human brain – as research models for developmental psychiatric disturbances. We will focus on glucocorticoids (GCs), some of the primary mediators of stress exposure on the organism, and use organoids as a model of early developing brain. Molecular mechanisms will be compared between ‘stressed’ and ‘unstressed’ conditions, by sequencing the transcriptomes of individual cells. Furthermore, since stress-related disorders are mediated through epigenetic mechanisms, the impact of elevated GC exposure on specific cell types in the cerebral organoid model will be quantified at the epigenome level. These novel and powerful techniques will allow us to deconstruct tissue heterogeneity, elucidating the fine molecular underpinnings of human vulnerability and response to stress. Comparing findings to evidence from longitudinal human cohorts of mothers and their babies who underwent stress during pregnancy will allow placement of findings into the clinical context. This research would pave the way for translation into clinical research, and expedite transitions from basic research to identification of at-risk populations, and even intervention strategies.

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The information about "PRENATALSTRESSOMICS" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2025-07-11 15:30:49) correctly updated