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PrenatalStressOmics
Prenatal Stress Investigation in Cerebral Organoids: a multi-omics study at the level of single cells
Total Cost €
0EC-Contrib. €
0Partnership
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0PrenatalStressOmics project word cloud
Explore the words cloud of the PrenatalStressOmics project. It provides you a very rough idea of what is the project "PrenatalStressOmics" about.
epigenome
cerebral
organoids
basic
mediated
human
stress
glucocorticoids
babies
gcs
primary
stem
transitions
types
translation
identification
pave
model
brain
hormone
fine
cells
tools
culture
risk
context
psychiatric
gc
questions
causing
elucidating
pregnancy
sequencing
vulnerability
elevated
illnesses
stressed
underwent
unstressed
mothers
made
tissue
recapitulate
imperative
disorders
heterogeneity
individual
techniques
underpinnings
precipitated
dimensional
population
mediators
tissues
organoid
mechanisms
neurobiology
strategies
animal
prenatal
progress
disease
models
mental
organism
longitudinal
clinical
placement
molecular
powerful
quantified
developmental
adversities
exposure
transcriptomes
deconstruct
disturbances
intervention
expedite
share
populations
life
epigenetic
25
cohorts
cell
period
Project "PrenatalStressOmics" data sheet
The following table provides information about the project.
| Coordinator |
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Total cost | 171˙460 € |
| EC max contribution | 171˙460 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2017 |
| Funding Scheme | MSCA-IF-EF-RI |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-02-01 to 2021-01-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV | DE (MUENCHEN) | coordinator | 171˙460.00 |
Map
Project objective
Mental illnesses affect 25% of the EU population and share increased disease risk through long-term changes to the stress hormone system. These are precipitated as adversities during early life, including the prenatal period. Given the role of stress in causing mental illnesses, it is imperative to learn more about the molecular mechanisms involved. Some progress has been made in elucidating the neurobiology of stress, but many questions cannot be addressed with current tools, which include animal models and 2-dimensional human cell culture systems. This proposal aims to establish 3-dimensional culture systems called cerebral organoids – stem-cell-derived tissues that recapitulate features of the human brain – as research models for developmental psychiatric disturbances. We will focus on glucocorticoids (GCs), some of the primary mediators of stress exposure on the organism, and use organoids as a model of early developing brain. Molecular mechanisms will be compared between ‘stressed’ and ‘unstressed’ conditions, by sequencing the transcriptomes of individual cells. Furthermore, since stress-related disorders are mediated through epigenetic mechanisms, the impact of elevated GC exposure on specific cell types in the cerebral organoid model will be quantified at the epigenome level. These novel and powerful techniques will allow us to deconstruct tissue heterogeneity, elucidating the fine molecular underpinnings of human vulnerability and response to stress. Comparing findings to evidence from longitudinal human cohorts of mothers and their babies who underwent stress during pregnancy will allow placement of findings into the clinical context. This research would pave the way for translation into clinical research, and expedite transitions from basic research to identification of at-risk populations, and even intervention strategies.
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The information about "PRENATALSTRESSOMICS" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-04-18 0:38:31) correctly updated