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GD TCR LIGAND

Identification of the ligand of a human public anti-HCMV/cancer γδ T cell receptor

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

GD TCR LIGAND project word cloud

Explore the words cloud of the GD TCR LIGAND project. It provides you a very rough idea of what is the project "GD TCR LIGAND" about.

prototype resonance group ligand host vermijlen isolate play utero broad binding unconventional gd ligands gene stimulators tcr bioid cellular first detect primary public fish pbmcs candidates cell vg8vd1 hcmv msca genes capacity profiling identification protection proximity stress interplay data antibodies individual cross vaccination adult infected verus immunotherapy receptor tested dependent stimulator line generation reactive indirect transformation plasmon discovered list direct stimulate david signals complement candidate surface killing enriched functional suggesting cells therfore plan assays literature human bodies transduced strategies cytomegalovirus infections expression expressing background expertise biotinylation reacts strategy cancer blocking implications

Project "GD TCR LIGAND" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE LIBRE DE BRUXELLES Organization address address: AVENUE FRANKLIN ROOSEVELT 50 city: BRUXELLES postcode: 1050 website: www.ulb.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Total cost	160˙800 €
EC max contribution	160˙800 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-03-01 to 2019-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE LIBRE DE BRUXELLES UNIVERSITE LIBRE DE BRUXELLES Organization address address: AVENUE FRANKLIN ROOSEVELT 50 city: BRUXELLES postcode: 1050 website: www.ulb.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	coordinator	160˙800.00

Map

Project objective

'gd T cells are the prototype of unconventional T cells and play an important role in the protection against infections and cancer. The group of David Vermijlen has recently discovered a human Vg8Vd1 T cell receptor (TCR) which was highly enriched in every individual (therfore 'public') infected in utero with human cytomegalovirus (HCMV), and that reacts towards adult cancer cells, suggesting that it can detect signals of 'cellular stress' induced in both infections and cell transformation. The major aim of this project is the identification of the ligand of this cross-reactive public Vg8Vd1 TCR. Two strategies will be adopted to address this aim. In the first strategy (indirect approach), a list of candidate ligands will be tested for the capacity to stimulate the TCR via functional assays. This list of genes is provided by gene expression profiling of target cells known to stimulate the public TCR ('stimulator cells') verus non-stimulators, as well as from data in literature. In the second strategy (direct approach), in order to isolate or 'fish' the ligand from a strong stimulator cell line we plan to adopt several methods, such as: i) production of blocking antibodies, ii) generation of 'gd bodies', iii) proximity dependent biotinylation (BioID). The direct binding of promising ligand candidates with the public Vg8Vd1 TCR will be further investigated by surface plasmon resonance. Finally, in order to address the potential of this project for cancer immunotherapy we will evaluate the killing of primary cancer cells expressing the ligand by public Vg8Vd1-transduced PBMCs. The background of the MSCA applicant on HCMV-host interplay will highly complement the expertise of the group of David Vermijlen on gd T cells. As the public Vg8Vd1 TCR is present in every individual, the identification of its ligand will have broad implications as a possible target for the development of novel vaccination and cancer immunotherapy strategies.'

Publications

List of publications.
year	authors and title	journal	last update
2018	David Vermijlen, Deborah Gatti, Ariadni Kouzeli, Teja Rus, Matthias Eberl Î³Î´ T cell responses: How many ligands will it take till we know? published pages: , ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2017.10.009	Seminars in Cell & Developmental Biology	2019-06-12

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The information about "GD TCR LIGAND" are provided by the European Opendata Portal: CORDIS opendata.