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Low Temperature Plasma for Applications in Medicine

Total Cost €


EC-Contrib. €






 LTPAM project word cloud

Explore the words cloud of the LTPAM project. It provides you a very rough idea of what is the project "LTPAM" about.

abundant    precursors    molecules    liquids    resembling    vivo    deeper    chemistries    bio    bacteria    initial    isotopically    biologically    physical    mimicking    diverse    cl    molecular    therapies    cytotoxicity    species    variety    chromatography    electron    spectrometry    lack    chemical    jet    clinical    biological    fail    water    paramagnetic    enhancement    goals    nuclear    influences    created    gels    structures    aid    burgeoning    reacting    emerged    magnetic    mass    standardise    bacterial    chemicals    radical    viral    vast    biomedical    generation    pressure    progression    onoo    models    employing    radicals    direct    reactive    ltp    temperature    diagnostics    plasmas    ambient    gas    sources    focussed    anti    responsible    generate    chemistry    ion    plasma    quantitative    resonance    atmospheric    milieu    resistant    exposure    world    identification    rf    cancer    labelled    air    secondary    lived    ionic    antibiotic    media    tissue    spectroscopy    aerosols    utilise   

Project "LTPAM" data sheet

The following table provides information about the project.


Organization address
address: PRINSSTRAAT 13
postcode: 2000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 172˙800 €
 EC max contribution 172˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2019-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) coordinator 172˙800.00


 Project objective

Atmospheric pressure low temperature plasma (LTP) is a burgeoning field due to its vast potential in biomedical applications. Reacting with ambient air, these plasmas generate a variety of molecular, ionic and radical species, responsible for the anti-bacterial, anti-viral and anti-cancer properties of LTP. It is especially important when more traditional therapies fail, such as antibiotic-resistant bacteria. Recently, a large number of studies of the biological effects of LTP emerged, as well as diagnostics of the gas phase LTP, and various models. However, the chemical and physical processes in biologically relevant media still lack detailed understanding. Water is an essential part of the bio-milieu, and both initial and secondary LTP-induced chemistries in liquids require deeper studies. This project will aim at several goals, which will aid the progression of LTP towards wide and diverse clinical use. 1) It will utilise the RF COST plasma jet (created to standardise the LTP research in Europe and the world). The sources of the reactive species induced by the jet will be studied by employing isotopically labelled molecules. 2) The plasma-induced chemistry will be studied in conditions mimicking those in vivo: (i) generation of secondary species from Cl-, one of the most abundant chemicals in bio-media, and assessment of their cytotoxicity; and (ii) quantitative identification of short-lived reactive species (radicals) created by LTP in gels, structures resembling tissue (this is especially important in the case of direct plasma exposure where radical chemistry greatly influences processes in liquids). 3) The enhancement of LTP effects will be studied via generation of ONOO- from its precursors in plasmas with aerosols. The work will be focussed on liquids’ analysis by electron paramagnetic resonance and nuclear magnetic resonance spectroscopy, mass spectrometry, ion chromatography, etc.


year authors and title journal last update
List of publications.
2019 Abraham Lin, Yury Gorbanev, Joey De Backer, Jinthe Van Loenhout, Wilma Van Boxem, Filip Lemière, Paul Cos, Sylvia Dewilde, Evelien Smits, Annemie Bogaerts
Non-Thermal Plasma as a Unique Delivery System of Short-Lived Reactive Oxygen and Nitrogen Species for Immunogenic Cell Death in Melanoma Cells
published pages: 1802062, ISSN: 2198-3844, DOI: 10.1002/advs.201802062
Advanced Science 2019-04-25
2019 Yury Gorbanev, Jonas Van der Paal, Wilma Van Boxem, Sylvia Dewilde, Annemie Bogaerts
Reaction of chloride anion with atomic oxygen in aqueous solutions: can cold plasma help in chemistry research?
published pages: 4117-4121, ISSN: 1463-9076, DOI: 10.1039/c8cp07550f
Physical Chemistry Chemical Physics 21/8 2019-04-25
2018 Y. Gorbanev, C. C. W. Verlackt, S. Tinck, E. Tuenter, K. Foubert, P. Cos, A. Bogaerts
Combining experimental and modelling approaches to study the sources of reactive species induced in water by the COST RF plasma jet
published pages: 2797-2808, ISSN: 1463-9076, DOI: 10.1039/c7cp07616a
Physical Chemistry Chemical Physics 20/4 2019-04-25
2018 Eveline Torfs, Jure Vajs, Maíra Bidart de Macedo, Freya Cools, Bieke Vanhoutte, Yury Gorbanev, Annemie Bogaerts, Luc Verschaeve, Guy Caljon, Louis Maes, Peter Delputte, Paul Cos, Janez Košmrlj, Davie Cappoen
Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds
published pages: 631-640, ISSN: 1747-0277, DOI: 10.1111/cbdd.13087
Chemical Biology & Drug Design 91/2 2019-04-25
2017 Wilma Van Boxem, Jonas Van der Paal, Yury Gorbanev, Steven Vanuytsel, Evelien Smits, Sylvia Dewilde, Annemie Bogaerts
Anti-cancer capacity of plasma-treated PBS: effect of chemical composition on cancer cell cytotoxicity
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-16758-8
Scientific Reports 7/1 2019-04-25
2018 Dominique Mannaerts, Ellen Faes, Paul Cos, Jacob J. Briedé, Wilfried Gyselaers, Jerome Cornette, Yury Gorbanev, Annemie Bogaerts, Marc Spaanderman, Emeline Van Craenenbroeck, Yves Jacquemyn
Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function
published pages: e0202919, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0202919
PLOS ONE 13/9 2019-04-25
2018 Fatemeh Rezaei, Yury Gorbanev, Michael Chys, Anton Nikiforov, Stijn W. H. Van Hulle, Paul Cos, Annemie Bogaerts, Nathalie De Geyter
Investigation of plasma-induced chemistry in organic solutions for enhanced electrospun PLA nanofibers
published pages: 1700226, ISSN: 1612-8850, DOI: 10.1002/ppap.201700226
Plasma Processes and Polymers 15/6 2019-04-25
2019 Yury Gorbanev, Annemie Bogaerts
Chemical Detection of Short-Lived Species Induced in Aqueous Media by Atmospheric Pressure Plasma
published pages: , ISSN: , DOI:
Atmospheric Pressure Plasma 2019-04-25
2018 Yury Gorbanev, Angela Privat-Maldonado, Annemie Bogaerts
Analysis of Short-Lived Reactive Species in Plasma–Air–Water Systems: The Dos and the Do Nots
published pages: 13151-13158, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b03336
Analytical Chemistry 90/22 2019-04-25
2018 Angela Privat-Maldonado, Yury Gorbanev, Sylvia Dewilde, Evelien Smits, Annemie Bogaerts
Reduction of Human Glioblastoma Spheroids Using Cold Atmospheric Plasma: The Combined Effect of Short- and Long-Lived Reactive Species
published pages: 394, ISSN: 2072-6694, DOI: 10.3390/cancers10110394
Cancers 10/11 2019-04-25
2018 Abraham Lin, Yury Gorbanev, Paul Cos, Evelien Smits, Annemie Bogaerts
Plasma Elicits Immunogenic Death In Melanoma Cells
published pages: 9, ISSN: 2212-8166, DOI: 10.1016/j.cpme.2017.12.013
Clinical Plasma Medicine 9 2019-04-25

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