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LTPAM SIGNED

Low Temperature Plasma for Applications in Medicine

Total Cost €

0

EC-Contrib. €

0

Partnership

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 LTPAM project word cloud

Explore the words cloud of the LTPAM project. It provides you a very rough idea of what is the project "LTPAM" about.

plasma    anti    plasmas    emerged    cytotoxicity    radicals    diverse    gels    bacteria    burgeoning    variety    atmospheric    rf    created    therapies    standardise    structures    spectroscopy    spectrometry    tissue    viral    vivo    cancer    reactive    resonance    pressure    quantitative    resistant    world    deeper    aid    secondary    employing    antibiotic    ltp    ion    precursors    gas    lack    focussed    ambient    magnetic    aerosols    mimicking    liquids    chemistry    direct    nuclear    reacting    biological    ionic    air    radical    initial    fail    generation    sources    bio    temperature    abundant    onoo    chemistries    media    chemical    paramagnetic    responsible    electron    physical    mass    utilise    influences    identification    chemicals    models    water    chromatography    biologically    molecules    isotopically    clinical    goals    molecular    resembling    progression    diagnostics    generate    biomedical    jet    vast    species    labelled    exposure    bacterial    lived    cl    enhancement    milieu   

Project "LTPAM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT ANTWERPEN 

Organization address
address: PRINSSTRAAT 13
city: ANTWERPEN
postcode: 2000
website: www.ua.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 172˙800 €
 EC max contribution 172˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) coordinator 172˙800.00

Map

 Project objective

Atmospheric pressure low temperature plasma (LTP) is a burgeoning field due to its vast potential in biomedical applications. Reacting with ambient air, these plasmas generate a variety of molecular, ionic and radical species, responsible for the anti-bacterial, anti-viral and anti-cancer properties of LTP. It is especially important when more traditional therapies fail, such as antibiotic-resistant bacteria. Recently, a large number of studies of the biological effects of LTP emerged, as well as diagnostics of the gas phase LTP, and various models. However, the chemical and physical processes in biologically relevant media still lack detailed understanding. Water is an essential part of the bio-milieu, and both initial and secondary LTP-induced chemistries in liquids require deeper studies. This project will aim at several goals, which will aid the progression of LTP towards wide and diverse clinical use. 1) It will utilise the RF COST plasma jet (created to standardise the LTP research in Europe and the world). The sources of the reactive species induced by the jet will be studied by employing isotopically labelled molecules. 2) The plasma-induced chemistry will be studied in conditions mimicking those in vivo: (i) generation of secondary species from Cl-, one of the most abundant chemicals in bio-media, and assessment of their cytotoxicity; and (ii) quantitative identification of short-lived reactive species (radicals) created by LTP in gels, structures resembling tissue (this is especially important in the case of direct plasma exposure where radical chemistry greatly influences processes in liquids). 3) The enhancement of LTP effects will be studied via generation of ONOO- from its precursors in plasmas with aerosols. The work will be focussed on liquids’ analysis by electron paramagnetic resonance and nuclear magnetic resonance spectroscopy, mass spectrometry, ion chromatography, etc.

 Publications

year authors and title journal last update
List of publications.
2019 Abraham Lin, Yury Gorbanev, Joey De Backer, Jinthe Van Loenhout, Wilma Van Boxem, Filip Lemière, Paul Cos, Sylvia Dewilde, Evelien Smits, Annemie Bogaerts
Non-Thermal Plasma as a Unique Delivery System of Short-Lived Reactive Oxygen and Nitrogen Species for Immunogenic Cell Death in Melanoma Cells
published pages: 1802062, ISSN: 2198-3844, DOI: 10.1002/advs.201802062
Advanced Science 2019-04-25
2019 Yury Gorbanev, Jonas Van der Paal, Wilma Van Boxem, Sylvia Dewilde, Annemie Bogaerts
Reaction of chloride anion with atomic oxygen in aqueous solutions: can cold plasma help in chemistry research?
published pages: 4117-4121, ISSN: 1463-9076, DOI: 10.1039/c8cp07550f
Physical Chemistry Chemical Physics 21/8 2019-04-25
2018 Y. Gorbanev, C. C. W. Verlackt, S. Tinck, E. Tuenter, K. Foubert, P. Cos, A. Bogaerts
Combining experimental and modelling approaches to study the sources of reactive species induced in water by the COST RF plasma jet
published pages: 2797-2808, ISSN: 1463-9076, DOI: 10.1039/c7cp07616a
Physical Chemistry Chemical Physics 20/4 2019-04-25
2018 Eveline Torfs, Jure Vajs, Maíra Bidart de Macedo, Freya Cools, Bieke Vanhoutte, Yury Gorbanev, Annemie Bogaerts, Luc Verschaeve, Guy Caljon, Louis Maes, Peter Delputte, Paul Cos, Janez Košmrlj, Davie Cappoen
Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds
published pages: 631-640, ISSN: 1747-0277, DOI: 10.1111/cbdd.13087
Chemical Biology & Drug Design 91/2 2019-04-25
2017 Wilma Van Boxem, Jonas Van der Paal, Yury Gorbanev, Steven Vanuytsel, Evelien Smits, Sylvia Dewilde, Annemie Bogaerts
Anti-cancer capacity of plasma-treated PBS: effect of chemical composition on cancer cell cytotoxicity
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-16758-8
Scientific Reports 7/1 2019-04-25
2018 Dominique Mannaerts, Ellen Faes, Paul Cos, Jacob J. Briedé, Wilfried Gyselaers, Jerome Cornette, Yury Gorbanev, Annemie Bogaerts, Marc Spaanderman, Emeline Van Craenenbroeck, Yves Jacquemyn
Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function
published pages: e0202919, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0202919
PLOS ONE 13/9 2019-04-25
2018 Fatemeh Rezaei, Yury Gorbanev, Michael Chys, Anton Nikiforov, Stijn W. H. Van Hulle, Paul Cos, Annemie Bogaerts, Nathalie De Geyter
Investigation of plasma-induced chemistry in organic solutions for enhanced electrospun PLA nanofibers
published pages: 1700226, ISSN: 1612-8850, DOI: 10.1002/ppap.201700226
Plasma Processes and Polymers 15/6 2019-04-25
2019 Yury Gorbanev, Annemie Bogaerts
Chemical Detection of Short-Lived Species Induced in Aqueous Media by Atmospheric Pressure Plasma
published pages: , ISSN: , DOI:
Atmospheric Pressure Plasma 2019-04-25
2018 Yury Gorbanev, Angela Privat-Maldonado, Annemie Bogaerts
Analysis of Short-Lived Reactive Species in Plasma–Air–Water Systems: The Dos and the Do Nots
published pages: 13151-13158, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b03336
Analytical Chemistry 90/22 2019-04-25
2018 Angela Privat-Maldonado, Yury Gorbanev, Sylvia Dewilde, Evelien Smits, Annemie Bogaerts
Reduction of Human Glioblastoma Spheroids Using Cold Atmospheric Plasma: The Combined Effect of Short- and Long-Lived Reactive Species
published pages: 394, ISSN: 2072-6694, DOI: 10.3390/cancers10110394
Cancers 10/11 2019-04-25
2018 Abraham Lin, Yury Gorbanev, Paul Cos, Evelien Smits, Annemie Bogaerts
Plasma Elicits Immunogenic Death In Melanoma Cells
published pages: 9, ISSN: 2212-8166, DOI: 10.1016/j.cpme.2017.12.013
Clinical Plasma Medicine 9 2019-04-25

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