LTPAM SIGNED
Low Temperature Plasma for Applications in Medicine
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the LTPAM project. It provides you a very rough idea of what is the project "LTPAM" about.
Project "LTPAM" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITEIT ANTWERPEN
Organization address contact info |
| Coordinator Country | Belgium [BE] |
| Total cost | 172˙800 € |
| EC max contribution | 172˙800 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2016 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-05-01 to 2019-04-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITEIT ANTWERPEN | BE (ANTWERPEN) | coordinator | 172˙800.00 |
Map
Project objective
Atmospheric pressure low temperature plasma (LTP) is a burgeoning field due to its vast potential in biomedical applications. Reacting with ambient air, these plasmas generate a variety of molecular, ionic and radical species, responsible for the anti-bacterial, anti-viral and anti-cancer properties of LTP. It is especially important when more traditional therapies fail, such as antibiotic-resistant bacteria. Recently, a large number of studies of the biological effects of LTP emerged, as well as diagnostics of the gas phase LTP, and various models. However, the chemical and physical processes in biologically relevant media still lack detailed understanding. Water is an essential part of the bio-milieu, and both initial and secondary LTP-induced chemistries in liquids require deeper studies. This project will aim at several goals, which will aid the progression of LTP towards wide and diverse clinical use. 1) It will utilise the RF COST plasma jet (created to standardise the LTP research in Europe and the world). The sources of the reactive species induced by the jet will be studied by employing isotopically labelled molecules. 2) The plasma-induced chemistry will be studied in conditions mimicking those in vivo: (i) generation of secondary species from Cl-, one of the most abundant chemicals in bio-media, and assessment of their cytotoxicity; and (ii) quantitative identification of short-lived reactive species (radicals) created by LTP in gels, structures resembling tissue (this is especially important in the case of direct plasma exposure where radical chemistry greatly influences processes in liquids). 3) The enhancement of LTP effects will be studied via generation of ONOO- from its precursors in plasmas with aerosols. The work will be focussed on liquids’ analysis by electron paramagnetic resonance and nuclear magnetic resonance spectroscopy, mass spectrometry, ion chromatography, etc.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Abraham Lin, Yury Gorbanev, Joey De Backer, Jinthe Van Loenhout, Wilma Van Boxem, Filip Lemière, Paul Cos, Sylvia Dewilde, Evelien Smits, Annemie Bogaerts Non-Thermal Plasma as a Unique Delivery System of Short-Lived Reactive Oxygen and Nitrogen Species for Immunogenic Cell Death in Melanoma Cells published pages: 1802062, ISSN: 2198-3844, DOI: 10.1002/advs.201802062 |
Advanced Science | 2019-04-25 |
| 2019 |
Yury Gorbanev, Jonas Van der Paal, Wilma Van Boxem, Sylvia Dewilde, Annemie Bogaerts Reaction of chloride anion with atomic oxygen in aqueous solutions: can cold plasma help in chemistry research? published pages: 4117-4121, ISSN: 1463-9076, DOI: 10.1039/c8cp07550f |
Physical Chemistry Chemical Physics 21/8 | 2019-04-25 |
| 2018 |
Y. Gorbanev, C. C. W. Verlackt, S. Tinck, E. Tuenter, K. Foubert, P. Cos, A. Bogaerts Combining experimental and modelling approaches to study the sources of reactive species induced in water by the COST RF plasma jet published pages: 2797-2808, ISSN: 1463-9076, DOI: 10.1039/c7cp07616a |
Physical Chemistry Chemical Physics 20/4 | 2019-04-25 |
| 2018 |
Eveline Torfs, Jure Vajs, MaÃra Bidart de Macedo, Freya Cools, Bieke Vanhoutte, Yury Gorbanev, Annemie Bogaerts, Luc Verschaeve, Guy Caljon, Louis Maes, Peter Delputte, Paul Cos, Janez KoÅ¡mrlj, Davie Cappoen Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds published pages: 631-640, ISSN: 1747-0277, DOI: 10.1111/cbdd.13087 |
Chemical Biology & Drug Design 91/2 | 2019-04-25 |
| 2017 |
Wilma Van Boxem, Jonas Van der Paal, Yury Gorbanev, Steven Vanuytsel, Evelien Smits, Sylvia Dewilde, Annemie Bogaerts Anti-cancer capacity of plasma-treated PBS: effect of chemical composition on cancer cell cytotoxicity published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-16758-8 |
Scientific Reports 7/1 | 2019-04-25 |
| 2018 |
Dominique Mannaerts, Ellen Faes, Paul Cos, Jacob J. Briedé, Wilfried Gyselaers, Jerome Cornette, Yury Gorbanev, Annemie Bogaerts, Marc Spaanderman, Emeline Van Craenenbroeck, Yves Jacquemyn Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function published pages: e0202919, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0202919 |
PLOS ONE 13/9 | 2019-04-25 |
| 2018 |
Fatemeh Rezaei, Yury Gorbanev, Michael Chys, Anton Nikiforov, Stijn W. H. Van Hulle, Paul Cos, Annemie Bogaerts, Nathalie De Geyter Investigation of plasma-induced chemistry in organic solutions for enhanced electrospun PLA nanofibers published pages: 1700226, ISSN: 1612-8850, DOI: 10.1002/ppap.201700226 |
Plasma Processes and Polymers 15/6 | 2019-04-25 |
| 2019 |
Yury Gorbanev, Annemie Bogaerts Chemical Detection of Short-Lived Species Induced in Aqueous Media by Atmospheric Pressure Plasma published pages: , ISSN: , DOI: |
Atmospheric Pressure Plasma | 2019-04-25 |
| 2018 |
Yury Gorbanev, Angela Privat-Maldonado, Annemie Bogaerts Analysis of Short-Lived Reactive Species in Plasma–Air–Water Systems: The Dos and the Do Nots published pages: 13151-13158, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b03336 |
Analytical Chemistry 90/22 | 2019-04-25 |
| 2018 |
Angela Privat-Maldonado, Yury Gorbanev, Sylvia Dewilde, Evelien Smits, Annemie Bogaerts Reduction of Human Glioblastoma Spheroids Using Cold Atmospheric Plasma: The Combined Effect of Short- and Long-Lived Reactive Species published pages: 394, ISSN: 2072-6694, DOI: 10.3390/cancers10110394 |
Cancers 10/11 | 2019-04-25 |
| 2018 |
Abraham Lin, Yury Gorbanev, Paul Cos, Evelien Smits, Annemie Bogaerts Plasma Elicits Immunogenic Death In Melanoma Cells published pages: 9, ISSN: 2212-8166, DOI: 10.1016/j.cpme.2017.12.013 |
Clinical Plasma Medicine 9 | 2019-04-25 |
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