Opendata, web and dolomites

CoMPOSE SIGNED

Cortical Microcircuits: Parvalbumin neurons Orchestrate Stress Eating

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CoMPOSE project word cloud

Explore the words cloud of the CoMPOSE project. It provides you a very rough idea of what is the project "CoMPOSE" about.

cortical    levels    stores    severe    adaptive    easily    chemogenetic    point    circuits    eating    choices    binge    obesity    caloric    prevention    understand    society    energy    prefrontal    human    regions    indicates    shape    yield    replenish    cortex    stressors    disorder    leads    brain    mice    output    coordinated    manipulate    health    strategies    serves    dietary    maladaptive    accessible    consequence    cheap    rising    continuous    pfc    tracing    animal    neural    vulnerable    viral    feeding    combination    recordings    neurons    stress    tight    circuit    manner    interneurons    psychological    regulation    people    techniques    vivo    food    arises    sending    projection    heterogenous    patterns    underlying    roles    drive    local    neuronal    shift    critical    intake    enhanced    purpose    overeat    behavior    modern    electrophysiological    unhealthy    pyramidal    physical    alarming    opposing    coordinate    inhibitory    phenomenon    situation    structure    mechanisms   

Project "CoMPOSE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 187˙572.00

Map

 Project objective

Stress leads to enhanced food intake and a shift in dietary choices towards more high-caloric and unhealthy food. While this serves an adaptive purpose to replenish energy stores after a physical challenge, in modern society where continuous psychological stressors are present and cheap unhealthy food easily accessible, this leads to an alarming situation where many people overeat. As a consequence, obesity levels are rising with severe consequences for our health. Especially people with an eating disorder, like binge-eating disorder, are vulnerable to this situation. Human and animal studies both point to a critical role of the prefrontal cortex (PFC) in coordinating stress-induced food intake. The prefrontal cortex is a highly heterogenous structure sending coordinated neuronal output to many brain regions with opposing roles in food regulation. This indicates that these circuits are under tight regulation of local interneurons. However how interneurons coordinate circuits for stress-induced feeding behavior is not known. In this project I aim to understand how Inhibitory interneurons shape output patterns of prefrontal cortical pyramidal neurons in a projection-specific manner to drive stress-induced food intake. To this aim I will use a combination of viral tracing techniques and in vivo electrophysiological recordings of identified PFC interneurons and pyramidal neurons in mice. Moreover I will use chemogenetic approaches to manipulate specific PFC pyramidal neural circuits to understand their role in stress eating responses. This will yield important insight into the circuit mechanisms underlying this maladaptive behavior. Studying how this phenomenon arises at the level of neuronal circuits will provide evidence-based targets for prevention strategies.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "COMPOSE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "COMPOSE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PaSION (2018)

A longitudinal assessment of treatment experience, symptoms and potential associations with biomarkers in cancer patients undergoing immune checkpoint inhibitor therapy

Read More  

ICARUS (2020)

Information Content of locAlisation: fRom classical to qUantum Systems

Read More  

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More