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Cortical Microcircuits: Parvalbumin neurons Orchestrate Stress Eating

Total Cost €


EC-Contrib. €






 CoMPOSE project word cloud

Explore the words cloud of the CoMPOSE project. It provides you a very rough idea of what is the project "CoMPOSE" about.

techniques    coordinate    sending    local    regions    prevention    output    society    indicates    choices    opposing    unhealthy    inhibitory    behavior    regulation    modern    situation    heterogenous    severe    mechanisms    easily    alarming    manner    enhanced    psychological    feeding    consequence    pfc    continuous    adaptive    pyramidal    chemogenetic    coordinated    health    point    cortical    disorder    shift    binge    stressors    energy    tight    serves    cheap    mice    maladaptive    stores    yield    rising    understand    recordings    manipulate    circuit    tracing    shape    purpose    dietary    leads    people    overeat    strategies    patterns    neural    caloric    structure    animal    combination    brain    levels    electrophysiological    vivo    drive    projection    physical    prefrontal    interneurons    replenish    eating    critical    circuits    neurons    obesity    roles    underlying    intake    arises    viral    human    vulnerable    stress    phenomenon    cortex    accessible    food    neuronal   

Project "CoMPOSE" data sheet

The following table provides information about the project.


Organization address
postcode: 3584 CX

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Stress leads to enhanced food intake and a shift in dietary choices towards more high-caloric and unhealthy food. While this serves an adaptive purpose to replenish energy stores after a physical challenge, in modern society where continuous psychological stressors are present and cheap unhealthy food easily accessible, this leads to an alarming situation where many people overeat. As a consequence, obesity levels are rising with severe consequences for our health. Especially people with an eating disorder, like binge-eating disorder, are vulnerable to this situation. Human and animal studies both point to a critical role of the prefrontal cortex (PFC) in coordinating stress-induced food intake. The prefrontal cortex is a highly heterogenous structure sending coordinated neuronal output to many brain regions with opposing roles in food regulation. This indicates that these circuits are under tight regulation of local interneurons. However how interneurons coordinate circuits for stress-induced feeding behavior is not known. In this project I aim to understand how Inhibitory interneurons shape output patterns of prefrontal cortical pyramidal neurons in a projection-specific manner to drive stress-induced food intake. To this aim I will use a combination of viral tracing techniques and in vivo electrophysiological recordings of identified PFC interneurons and pyramidal neurons in mice. Moreover I will use chemogenetic approaches to manipulate specific PFC pyramidal neural circuits to understand their role in stress eating responses. This will yield important insight into the circuit mechanisms underlying this maladaptive behavior. Studying how this phenomenon arises at the level of neuronal circuits will provide evidence-based targets for prevention strategies.

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The information about "COMPOSE" are provided by the European Opendata Portal: CORDIS opendata.

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