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TBX18

Transcriptional regulation by TBX18 in vascular development and disease

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

TBX18 project word cloud

Explore the words cloud of the TBX18 project. It provides you a very rough idea of what is the project "TBX18" about.

transcriptional putative mutants roles networks malfunction muscle preliminary observations led aortic diseases hypothesis mural lethality multiple tbx18 critical regulated vessels blood homeostasis ablation indicates vascular regulation human disease cre place functional data mice phenotypes gene respectively absence understand rupture adult selectively small aneurysmal organs tortuosity enclose aneurysm smooth showed expressed genes cells pdgfrb involvement pericytes

Project "TBX18" data sheet

The following table provides information about the project.

Coordinator	HUMANITAS UNIVERSITY Organization address address: VIA RITA LEVI MONTALCINI SNC city: PIEVE EMANUELE postcode: 20090 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	168˙277 €
EC max contribution	168˙277 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-RI
Starting year	2018
Duration (year-month-day)	from 2018-01-02 to 2020-01-01

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	HUMANITAS UNIVERSITY HUMANITAS UNIVERSITY Organization address address: VIA RITA LEVI MONTALCINI SNC city: PIEVE EMANUELE postcode: 20090 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PIEVE EMANUELE)	coordinator	168˙277.00

Map

Project objective

Mural cells (pericytes and vascular smooth muscle) enclose blood vessels and are critical for vascular homeostasis. Absence or malfunction of pericytes or vascular smooth muscle results in aneurysm formation in small or large blood vessels, respectively. Our previous work showed Tbx18 is selectively expressed in mural cells of multiple adult organs. Preliminary data indicates that, in mice, ablation of Tbx18 in mural cells results in aortic tortuosity and lethality due to rupture. These observations led to the hypothesis that transcriptional regulation by TBX18 in mural cells is critical for the development of functional vascular networks. To fully understand the roles of TBX18 in mural cells and eventually place it as a gene involved in human vascular disease, we propose to: 1) fully characterize the vascular phenotypes of Pdgfrb- Cre;Tbx18 mutants; 2) identify genes directly regulated by Tbx18 in mural cells; and 3) test a putative involvement of TBX18 in human aneurysmal diseases.

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The information about "TBX18" are provided by the European Opendata Portal: CORDIS opendata.