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AlzheimersInAction SIGNED

AlzheimersInAction: A multi-disciplinary approach to determine the cellular and molecular mechanisms underlying the inflammatory response to amyloid-β in Alzheimer’s disease.

Total Cost €


EC-Contrib. €






 AlzheimersInAction project word cloud

Explore the words cloud of the AlzheimersInAction project. It provides you a very rough idea of what is the project "AlzheimersInAction" about.

devastation    capturing    onset    downstream    comorbid    dementia    rapid    beta    causes    lack    forms    parallel    activation    generates    time    outputs    alzheimer    pathogenesis    urgent    promoter    absence    disease    edge    biological    overproduction    drug    amyloid    interventions    cellular    brain    neurological    alarming    output    biology    electrophysiology    alzheimersinaction    living    cutting    occurring    made    neuronal    cure    rate    million    techniques    economy    patients    imaging    powerful    health    genetics    symptoms    difficulties    visibility    slow    fold    damage    synaptic    progression    predicted    underlying    cells    critical    neurobiological    versatile    delay    molecular    inflammatory    drosophila    fill    immune    enormous    ad    develops    combines    families    diseases    completion    computational    disciplinary    leads    difficult    action    nature    gaps    overcome    stages    treatments    lapse    cell    behavioural    therapeutic    flies    difficulty    pathologies    mechanisms    actually    citizens   

Project "AlzheimersInAction" data sheet

The following table provides information about the project.


Organization address
postcode: EH8 9YL

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2023-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 224˙933.00


 Project objective

In addition to devastation for the patients and their families, Alzheimer’s disease (AD) generates enormous costs for the wider European economy and is an urgent health priority. There are currently no drug treatments that can cure AD or other common forms of dementia. This absence of therapeutic interventions comes from a lack of understanding about the biological changes that cause most neurological diseases. It is critical to fill in the gaps in our understanding of what biological changes are occurring during the early stages of AD in order to develop treatments that could slow progression or delay the onset of AD. The comorbid nature of this disease and the difficulty of capturing neurobiological processes in action in real time have made it very difficult to determine what changes in the AD brain actually cause the synaptic and neuronal damage that leads to behavioural symptoms. To overcome these difficulties, I propose a multi-disciplinary approach that combines and develops cutting-edge techniques in Drosophila cell biology, molecular biology, time-lapse imaging, computational modelling, and electrophysiology in parallel with exploitation of the powerful molecular genetics, versatile promoter systems and rapid development of flies. Specifically, throughout AlzheimersInAction I will use these techniques to develop an in depth understanding of how an overproduction of amyloid-β causes downstream pathologies, and how activation of the immune cells during AD causes disease pathogenesis. By the completion of this project we will have a greater understanding of the cellular and molecular mechanisms underlying the inflammatory response to Aβ in Alzheimer’s disease. With 10.5 million EU citizens currently living with dementia, and this value predicted to increase at an alarming rate of 2-fold every 20 years, the outputs from AlzheimersInAction will contribute to the research output, visibility, and economy of Europe.

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The information about "ALZHEIMERSINACTION" are provided by the European Opendata Portal: CORDIS opendata.

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