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AlzheimersInAction SIGNED

AlzheimersInAction: A multi-disciplinary approach to determine the cellular and molecular mechanisms underlying the inflammatory response to amyloid-β in Alzheimer’s disease.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AlzheimersInAction project word cloud

Explore the words cloud of the AlzheimersInAction project. It provides you a very rough idea of what is the project "AlzheimersInAction" about.

gaps    mechanisms    time    disciplinary    million    slow    biological    overproduction    inflammatory    interventions    damage    drug    cure    versatile    progression    output    nature    difficulties    computational    forms    immune    comorbid    treatments    made    families    pathogenesis    visibility    urgent    imaging    biology    health    stages    devastation    difficult    actually    disease    alarming    critical    onset    amyloid    alzheimer    outputs    techniques    delay    completion    cellular    action    lack    powerful    therapeutic    rapid    symptoms    living    absence    alzheimersinaction    predicted    cell    combines    overcome    cutting    citizens    fill    molecular    capturing    diseases    leads    causes    occurring    parallel    brain    difficulty    flies    electrophysiology    edge    genetics    neurobiological    neurological    enormous    pathologies    promoter    downstream    neuronal    drosophila    fold    beta    patients    economy    behavioural    generates    activation    cells    dementia    lapse    rate    synaptic    underlying    ad    develops   

Project "AlzheimersInAction" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 224˙933.00

Map

 Project objective

In addition to devastation for the patients and their families, Alzheimer’s disease (AD) generates enormous costs for the wider European economy and is an urgent health priority. There are currently no drug treatments that can cure AD or other common forms of dementia. This absence of therapeutic interventions comes from a lack of understanding about the biological changes that cause most neurological diseases. It is critical to fill in the gaps in our understanding of what biological changes are occurring during the early stages of AD in order to develop treatments that could slow progression or delay the onset of AD. The comorbid nature of this disease and the difficulty of capturing neurobiological processes in action in real time have made it very difficult to determine what changes in the AD brain actually cause the synaptic and neuronal damage that leads to behavioural symptoms. To overcome these difficulties, I propose a multi-disciplinary approach that combines and develops cutting-edge techniques in Drosophila cell biology, molecular biology, time-lapse imaging, computational modelling, and electrophysiology in parallel with exploitation of the powerful molecular genetics, versatile promoter systems and rapid development of flies. Specifically, throughout AlzheimersInAction I will use these techniques to develop an in depth understanding of how an overproduction of amyloid-β causes downstream pathologies, and how activation of the immune cells during AD causes disease pathogenesis. By the completion of this project we will have a greater understanding of the cellular and molecular mechanisms underlying the inflammatory response to Aβ in Alzheimer’s disease. With 10.5 million EU citizens currently living with dementia, and this value predicted to increase at an alarming rate of 2-fold every 20 years, the outputs from AlzheimersInAction will contribute to the research output, visibility, and economy of Europe.

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The information about "ALZHEIMERSINACTION" are provided by the European Opendata Portal: CORDIS opendata.

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