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AlzheimersInAction SIGNED

AlzheimersInAction: A multi-disciplinary approach to determine the cellular and molecular mechanisms underlying the inflammatory response to amyloid-β in Alzheimer’s disease.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 AlzheimersInAction project word cloud

Explore the words cloud of the AlzheimersInAction project. It provides you a very rough idea of what is the project "AlzheimersInAction" about.

cure    immune    diseases    capturing    edge    damage    lack    overcome    neurological    amyloid    action    parallel    time    rapid    enormous    treatments    million    brain    onset    synaptic    alzheimersinaction    genetics    cellular    fill    neuronal    cell    beta    completion    output    dementia    therapeutic    cells    urgent    biology    outputs    patients    delay    families    develops    activation    slow    forms    rate    occurring    disease    combines    gaps    economy    progression    versatile    downstream    promoter    generates    leads    nature    difficulty    stages    mechanisms    actually    techniques    neurobiological    electrophysiology    molecular    made    computational    comorbid    difficult    pathologies    drosophila    alzheimer    critical    citizens    symptoms    interventions    predicted    drug    absence    visibility    behavioural    biological    overproduction    difficulties    powerful    inflammatory    living    underlying    pathogenesis    causes    alarming    imaging    flies    disciplinary    health    fold    devastation    cutting    lapse    ad   

Project "AlzheimersInAction" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 224˙933.00

Map

 Project objective

In addition to devastation for the patients and their families, Alzheimer’s disease (AD) generates enormous costs for the wider European economy and is an urgent health priority. There are currently no drug treatments that can cure AD or other common forms of dementia. This absence of therapeutic interventions comes from a lack of understanding about the biological changes that cause most neurological diseases. It is critical to fill in the gaps in our understanding of what biological changes are occurring during the early stages of AD in order to develop treatments that could slow progression or delay the onset of AD. The comorbid nature of this disease and the difficulty of capturing neurobiological processes in action in real time have made it very difficult to determine what changes in the AD brain actually cause the synaptic and neuronal damage that leads to behavioural symptoms. To overcome these difficulties, I propose a multi-disciplinary approach that combines and develops cutting-edge techniques in Drosophila cell biology, molecular biology, time-lapse imaging, computational modelling, and electrophysiology in parallel with exploitation of the powerful molecular genetics, versatile promoter systems and rapid development of flies. Specifically, throughout AlzheimersInAction I will use these techniques to develop an in depth understanding of how an overproduction of amyloid-β causes downstream pathologies, and how activation of the immune cells during AD causes disease pathogenesis. By the completion of this project we will have a greater understanding of the cellular and molecular mechanisms underlying the inflammatory response to Aβ in Alzheimer’s disease. With 10.5 million EU citizens currently living with dementia, and this value predicted to increase at an alarming rate of 2-fold every 20 years, the outputs from AlzheimersInAction will contribute to the research output, visibility, and economy of Europe.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ALZHEIMERSINACTION" project.

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Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ALZHEIMERSINACTION" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2023-12-02 12:34:21) correctly updated