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SMSC SIGNED

Single-Molecule Studies on Condensin

Total Cost €

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EC-Contrib. €

0

Partnership

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 SMSC project word cloud

Explore the words cloud of the SMSC project. It provides you a very rough idea of what is the project "SMSC" about.

ryu    speed    meters    experts    distributed    enters    molecular    technique    dekker    cell    prof    50ms    interdisciplinary    condenses    innovative    binding    biophysics    copy    small    volume    structure    video    replicated    combined    unknown    hottest    leader    gets    few    laboratory    resolution    condensin    chromosomes    spatiotemporal    genome    mitosis    collectively    dimers    demands    rate    embraces    micrometer    world    meet    dr    reveal    je    proposes    imaging    conformational    microscopy    entire    cees    size    kyung    hydrolysis    for    domains    formed    exactly    synergetic    of    time    kleisin    mechanism    understand    protein    afm    effort    compact    images    1nm    division    correlate    biochemistry    atp    cells    record    exits    magnetic    techniques    fluorescent    daughter    condensation    tweezers    dna    hs    orthogonal    physiological    smc    molecule    lab    compacted    chromosome    cooperative    ring    interactions    segregated    shapes    single    fluorescence    clues    heat   

Project "SMSC" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT DELFT 

Organization address
address: STEVINWEG 1
city: DELFT
postcode: 2628 CN
website: www.tudelft.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://ceesdekkerlab.nl
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT DELFT NL (DELFT) coordinator 177˙598.00

Map

 Project objective

For division of each of our cells, 2 meters of DNA should be replicated, compacted into a few-micrometer size chromosomes that are segregated and distributed via mitosis, so that each daughter cell gets exactly one copy. How this large DNA genome is well organized into such a small volume is one of the hottest issues for the understanding of chromosomes. Condensin, a ring-like structure formed by SMC dimers, kleisin, and two heat domains, embraces DNA and condenses the DNA using ATP hydrolysis. However, the molecular mechanism on how conformational changes of condensin compact DNA is still unknown. Here, the applicant Dr. Je-Kyung Ryu proposes to use two orthogonal single-molecule approaches, “high-speed AFM (HS AFM)” and “single-molecule fluorescent magnetic tweezers” to reveal the molecular mechanism of condensin. HS AFM imaging is a unique technique to record video-rate real-time images for entire structure of a protein in physiological condition with high spatiotemporal resolution (~1nm, ~50ms). In addition, using single-molecule fluorescence microscopy combined with magnetic tweezers, the applicant can understand how the cooperative binding of condensin to DNA correlate with DNA condensation. These two approaches will not only provide most important clues to understand the mechanism of condensin how DNA enters and exits the condensin ring and how condensin shapes chromosome but also include technical advances in single-molecule techniques. This work will be carried out in the laboratory of Prof. Cees Dekker, who is a world leader in HS AFM and single-molecule biophysics of DNA-protein interactions. The applicant’s experts in single-molecule biophysics, fluorescence microscopy, and biochemistry will make synergetic effects with the resources of the Dekker lab to collectively meet the interdisciplinary demands of the innovative effort.

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The information about "SMSC" are provided by the European Opendata Portal: CORDIS opendata.

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