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SMSC SIGNED

Single-Molecule Studies on Condensin

Total Cost €

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EC-Contrib. €

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Partnership

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 SMSC project word cloud

Explore the words cloud of the SMSC project. It provides you a very rough idea of what is the project "SMSC" about.

compacted    entire    effort    biochemistry    interdisciplinary    dimers    size    biophysics    understand    world    heat    reveal    mechanism    unknown    leader    cees    magnetic    gets    meters    ring    hottest    condensation    hydrolysis    combined    ryu    imaging    mitosis    1nm    fluorescent    protein    techniques    lab    micrometer    molecular    hs    segregated    record    50ms    orthogonal    correlate    of    collectively    laboratory    experts    cooperative    resolution    prof    exits    shapes    few    fluorescence    condensin    molecule    cells    je    for    cell    structure    formed    clues    rate    time    microscopy    tweezers    conformational    proposes    dekker    kyung    distributed    enters    dna    chromosome    innovative    demands    division    domains    small    speed    spatiotemporal    afm    single    exactly    daughter    dr    atp    images    embraces    technique    copy    interactions    replicated    chromosomes    binding    kleisin    physiological    video    smc    meet    synergetic    genome    volume    compact    condenses   

Project "SMSC" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT DELFT 

Organization address
address: STEVINWEG 1
city: DELFT
postcode: 2628 CN
website: www.tudelft.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://ceesdekkerlab.nl
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT DELFT NL (DELFT) coordinator 177˙598.00

Map

 Project objective

For division of each of our cells, 2 meters of DNA should be replicated, compacted into a few-micrometer size chromosomes that are segregated and distributed via mitosis, so that each daughter cell gets exactly one copy. How this large DNA genome is well organized into such a small volume is one of the hottest issues for the understanding of chromosomes. Condensin, a ring-like structure formed by SMC dimers, kleisin, and two heat domains, embraces DNA and condenses the DNA using ATP hydrolysis. However, the molecular mechanism on how conformational changes of condensin compact DNA is still unknown. Here, the applicant Dr. Je-Kyung Ryu proposes to use two orthogonal single-molecule approaches, “high-speed AFM (HS AFM)” and “single-molecule fluorescent magnetic tweezers” to reveal the molecular mechanism of condensin. HS AFM imaging is a unique technique to record video-rate real-time images for entire structure of a protein in physiological condition with high spatiotemporal resolution (~1nm, ~50ms). In addition, using single-molecule fluorescence microscopy combined with magnetic tweezers, the applicant can understand how the cooperative binding of condensin to DNA correlate with DNA condensation. These two approaches will not only provide most important clues to understand the mechanism of condensin how DNA enters and exits the condensin ring and how condensin shapes chromosome but also include technical advances in single-molecule techniques. This work will be carried out in the laboratory of Prof. Cees Dekker, who is a world leader in HS AFM and single-molecule biophysics of DNA-protein interactions. The applicant’s experts in single-molecule biophysics, fluorescence microscopy, and biochemistry will make synergetic effects with the resources of the Dekker lab to collectively meet the interdisciplinary demands of the innovative effort.

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The information about "SMSC" are provided by the European Opendata Portal: CORDIS opendata.

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