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Single-Molecule Studies on Condensin

Total Cost €


EC-Contrib. €






 SMSC project word cloud

Explore the words cloud of the SMSC project. It provides you a very rough idea of what is the project "SMSC" about.

techniques    smc    single    copy    daughter    distributed    imaging    reveal    proposes    rate    spatiotemporal    structure    domains    cells    lab    compacted    innovative    gets    50ms    condenses    ring    correlate    cees    ryu    record    understand    experts    resolution    small    segregated    afm    synergetic    dimers    formed    unknown    atp    exactly    time    conformational    molecule    kleisin    kyung    micrometer    for    fluorescent    tweezers    laboratory    size    world    molecular    interdisciplinary    chromosome    clues    shapes    chromosomes    dr    physiological    magnetic    images    division    dekker    leader    technique    dna    collectively    meters    binding    meet    biophysics    condensation    protein    of    mitosis    1nm    exits    volume    effort    mechanism    cell    heat    prof    biochemistry    compact    hydrolysis    orthogonal    replicated    few    je    condensin    genome    cooperative    video    enters    fluorescence    speed    entire    hs    microscopy    demands    combined    interactions    embraces    hottest   

Project "SMSC" data sheet

The following table provides information about the project.


Organization address
address: STEVINWEG 1
city: DELFT
postcode: 2628 CN

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT DELFT NL (DELFT) coordinator 177˙598.00


 Project objective

For division of each of our cells, 2 meters of DNA should be replicated, compacted into a few-micrometer size chromosomes that are segregated and distributed via mitosis, so that each daughter cell gets exactly one copy. How this large DNA genome is well organized into such a small volume is one of the hottest issues for the understanding of chromosomes. Condensin, a ring-like structure formed by SMC dimers, kleisin, and two heat domains, embraces DNA and condenses the DNA using ATP hydrolysis. However, the molecular mechanism on how conformational changes of condensin compact DNA is still unknown. Here, the applicant Dr. Je-Kyung Ryu proposes to use two orthogonal single-molecule approaches, “high-speed AFM (HS AFM)” and “single-molecule fluorescent magnetic tweezers” to reveal the molecular mechanism of condensin. HS AFM imaging is a unique technique to record video-rate real-time images for entire structure of a protein in physiological condition with high spatiotemporal resolution (~1nm, ~50ms). In addition, using single-molecule fluorescence microscopy combined with magnetic tweezers, the applicant can understand how the cooperative binding of condensin to DNA correlate with DNA condensation. These two approaches will not only provide most important clues to understand the mechanism of condensin how DNA enters and exits the condensin ring and how condensin shapes chromosome but also include technical advances in single-molecule techniques. This work will be carried out in the laboratory of Prof. Cees Dekker, who is a world leader in HS AFM and single-molecule biophysics of DNA-protein interactions. The applicant’s experts in single-molecule biophysics, fluorescence microscopy, and biochemistry will make synergetic effects with the resources of the Dekker lab to collectively meet the interdisciplinary demands of the innovative effort.

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The information about "SMSC" are provided by the European Opendata Portal: CORDIS opendata.

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