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CriTiClean

Supercritical carbon dioxide for delipidation of soft tissue - Suppressing transplant rejection.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CriTiClean project word cloud

Explore the words cloud of the CriTiClean project. It provides you a very rough idea of what is the project "CriTiClean" about.

organ    situ    spectroscopy    time    health    donor    avoids    vitro    molecules    damaging    dream    quality    risk    capacity    lipids    extract    rejection    tissue    mixtures    global    pose    lifelong    ethanol    components    remnant    waiting    dioxide    therapy    antigens    lipid    patients    119    critical    clean    raman    solubility    carbon    suppress    biological    solid    immunosuppression    polar    matrices    threat    soft    immunosuppressive    compounds    lose    human    efficient    life    arteries    remove    molecular    water    weight    brings    amounts    cleaned    recipient    scco2    structural    organism    linked    immunoresponse    cellular    chemical    performed    social    fundamental    prior    fresh    proteins    chronic    animal    organs    provokes    lack    lipoproteins    biomedical    873    mechanical    2014    survive    people    removing    constitutes    extractability    glycolipids    safe    insoluble    recellularization    transplanted    fluid    preparation    receive    severe    10    toxic    treatments    explore    supercritical    transplantation    pulmonary    hope   

Project "CriTiClean" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 173˙857 €
 EC max contribution 173˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-22   to  2019-07-13

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 173˙857.00

Map

 Project objective

The lack of donor organs and tissue constitutes a health and social problem. In 2014 about 119.873 organs were transplanted, that is less than the 10% of global needs. Critical patients do not survive the waiting time while transplanted people must receive lifelong immunosuppressive therapy with severe side effects. Also, there is a risk to lose the new organ to chronic rejection, which is linked to the presence of cellular components e.g. glycolipids and lipoproteins in the donor tissue. There is currently no process to remove lipids and lipid antigens from soft tissue prior transplantation.

Supercritical carbon dioxide (scCO2) is known to extract lipids from solid matrices, while polar molecules of high molecular weight, such as structural proteins in soft tissue, are insoluble. In this project we will explore the use of scCO2 to remove lipid compounds from soft tissue (i.e. pulmonary arteries) as a novel process for tissue preparation in order to suppress the main cause of rejection associated with transplantation. Fundamental studies on solubility of lipids in scCO2-water-ethanol mixtures are necessary to evaluate the extractability of lipids from fresh tissue, and will be performed by 'in-situ' Raman spectroscopy. Our approach avoids the use of current chemical and biological treatments that risk damaging the tissue and pose a toxic threat to the recipient organism. The mechanical properties of the “cleaned” tissue, the immunoresponse that provokes and its capacity for recellularization will be studied 'in vitro' and related to the amounts and type of remnant lipid compounds.

The project brings supercritical fluid technology into the biomedical field. This work will lead to efficient methodologies to “clean” all kind of organs/soft tissue and will enable safe animal-to-human transplantation, a current dream that will increase the hope of critical patients and improve life-quality after transplantation by removing the need of immunosuppression.

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The information about "CRITICLEAN" are provided by the European Opendata Portal: CORDIS opendata.

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