CriTiClean
Supercritical carbon dioxide for delipidation of soft tissue - Suppressing transplant rejection.
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0CriTiClean project word cloud
Explore the words cloud of the CriTiClean project. It provides you a very rough idea of what is the project "CriTiClean" about.
Project "CriTiClean" data sheet
The following table provides information about the project.
| Coordinator |
LUNDS UNIVERSITET
Organization address contact info |
| Coordinator Country | Sweden [SE] |
| Total cost | 173˙857 € |
| EC max contribution | 173˙857 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2016 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-05-22 to 2019-07-13 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | LUNDS UNIVERSITET | SE (LUND) | coordinator | 173˙857.00 |
Map
Project objective
The lack of donor organs and tissue constitutes a health and social problem. In 2014 about 119.873 organs were transplanted, that is less than the 10% of global needs. Critical patients do not survive the waiting time while transplanted people must receive lifelong immunosuppressive therapy with severe side effects. Also, there is a risk to lose the new organ to chronic rejection, which is linked to the presence of cellular components e.g. glycolipids and lipoproteins in the donor tissue. There is currently no process to remove lipids and lipid antigens from soft tissue prior transplantation.
Supercritical carbon dioxide (scCO2) is known to extract lipids from solid matrices, while polar molecules of high molecular weight, such as structural proteins in soft tissue, are insoluble. In this project we will explore the use of scCO2 to remove lipid compounds from soft tissue (i.e. pulmonary arteries) as a novel process for tissue preparation in order to suppress the main cause of rejection associated with transplantation. Fundamental studies on solubility of lipids in scCO2-water-ethanol mixtures are necessary to evaluate the extractability of lipids from fresh tissue, and will be performed by 'in-situ' Raman spectroscopy. Our approach avoids the use of current chemical and biological treatments that risk damaging the tissue and pose a toxic threat to the recipient organism. The mechanical properties of the “cleaned” tissue, the immunoresponse that provokes and its capacity for recellularization will be studied 'in vitro' and related to the amounts and type of remnant lipid compounds.
The project brings supercritical fluid technology into the biomedical field. This work will lead to efficient methodologies to “clean” all kind of organs/soft tissue and will enable safe animal-to-human transplantation, a current dream that will increase the hope of critical patients and improve life-quality after transplantation by removing the need of immunosuppression.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CRITICLEAN" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "CRITICLEAN" are provided by the European Opendata Portal: CORDIS opendata.