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CriTiClean

Supercritical carbon dioxide for delipidation of soft tissue - Suppressing transplant rejection.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CriTiClean project word cloud

Explore the words cloud of the CriTiClean project. It provides you a very rough idea of what is the project "CriTiClean" about.

vitro    hope    people    remove    cleaned    biomedical    quality    solid    avoids    organs    insoluble    clean    lose    ethanol    structural    compounds    pulmonary    brings    soft    life    provokes    explore    supercritical    removing    global    risk    solubility    social    organ    threat    119    efficient    extract    performed    preparation    scco2    polar    molecules    lipid    carbon    lipoproteins    immunoresponse    situ    prior    lack    capacity    critical    amounts    chronic    transplanted    constitutes    proteins    extractability    safe    pose    toxic    treatments    matrices    lipids    animal    glycolipids    patients    receive    raman    survive    weight    fresh    health    time    damaging    chemical    mechanical    recipient    molecular    dioxide    severe    lifelong    remnant    donor    mixtures    biological    cellular    10    spectroscopy    antigens    immunosuppression    recellularization    components    waiting    tissue    water    human    873    arteries    transplantation    immunosuppressive    dream    fundamental    therapy    linked    2014    suppress    rejection    organism    fluid   

Project "CriTiClean" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 173˙857 €
 EC max contribution 173˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-22   to  2019-07-13

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 173˙857.00

Map

 Project objective

The lack of donor organs and tissue constitutes a health and social problem. In 2014 about 119.873 organs were transplanted, that is less than the 10% of global needs. Critical patients do not survive the waiting time while transplanted people must receive lifelong immunosuppressive therapy with severe side effects. Also, there is a risk to lose the new organ to chronic rejection, which is linked to the presence of cellular components e.g. glycolipids and lipoproteins in the donor tissue. There is currently no process to remove lipids and lipid antigens from soft tissue prior transplantation.

Supercritical carbon dioxide (scCO2) is known to extract lipids from solid matrices, while polar molecules of high molecular weight, such as structural proteins in soft tissue, are insoluble. In this project we will explore the use of scCO2 to remove lipid compounds from soft tissue (i.e. pulmonary arteries) as a novel process for tissue preparation in order to suppress the main cause of rejection associated with transplantation. Fundamental studies on solubility of lipids in scCO2-water-ethanol mixtures are necessary to evaluate the extractability of lipids from fresh tissue, and will be performed by 'in-situ' Raman spectroscopy. Our approach avoids the use of current chemical and biological treatments that risk damaging the tissue and pose a toxic threat to the recipient organism. The mechanical properties of the “cleaned” tissue, the immunoresponse that provokes and its capacity for recellularization will be studied 'in vitro' and related to the amounts and type of remnant lipid compounds.

The project brings supercritical fluid technology into the biomedical field. This work will lead to efficient methodologies to “clean” all kind of organs/soft tissue and will enable safe animal-to-human transplantation, a current dream that will increase the hope of critical patients and improve life-quality after transplantation by removing the need of immunosuppression.

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The information about "CRITICLEAN" are provided by the European Opendata Portal: CORDIS opendata.

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