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CriTiClean

Supercritical carbon dioxide for delipidation of soft tissue - Suppressing transplant rejection.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CriTiClean project word cloud

Explore the words cloud of the CriTiClean project. It provides you a very rough idea of what is the project "CriTiClean" about.

organ    provokes    donor    recellularization    waiting    animal    compounds    solid    weight    glycolipids    receive    immunosuppressive    supercritical    lifelong    water    performed    prior    capacity    removing    insoluble    human    vitro    toxic    mechanical    cellular    tissue    clean    chronic    pulmonary    avoids    health    raman    remnant    dream    therapy    social    immunoresponse    immunosuppression    873    structural    molecular    pose    life    lipids    organs    remove    matrices    lipid    components    recipient    biological    dioxide    lipoproteins    severe    spectroscopy    solubility    10    2014    biomedical    situ    people    threat    extractability    brings    extract    suppress    explore    mixtures    efficient    risk    carbon    treatments    transplanted    fluid    proteins    scco2    antigens    amounts    time    patients    molecules    ethanol    soft    lack    fundamental    quality    preparation    chemical    linked    cleaned    critical    constitutes    fresh    polar    transplantation    damaging    lose    organism    global    hope    rejection    119    arteries    safe    survive   

Project "CriTiClean" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 173˙857 €
 EC max contribution 173˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-22   to  2019-07-13

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 173˙857.00

Map

 Project objective

The lack of donor organs and tissue constitutes a health and social problem. In 2014 about 119.873 organs were transplanted, that is less than the 10% of global needs. Critical patients do not survive the waiting time while transplanted people must receive lifelong immunosuppressive therapy with severe side effects. Also, there is a risk to lose the new organ to chronic rejection, which is linked to the presence of cellular components e.g. glycolipids and lipoproteins in the donor tissue. There is currently no process to remove lipids and lipid antigens from soft tissue prior transplantation.

Supercritical carbon dioxide (scCO2) is known to extract lipids from solid matrices, while polar molecules of high molecular weight, such as structural proteins in soft tissue, are insoluble. In this project we will explore the use of scCO2 to remove lipid compounds from soft tissue (i.e. pulmonary arteries) as a novel process for tissue preparation in order to suppress the main cause of rejection associated with transplantation. Fundamental studies on solubility of lipids in scCO2-water-ethanol mixtures are necessary to evaluate the extractability of lipids from fresh tissue, and will be performed by 'in-situ' Raman spectroscopy. Our approach avoids the use of current chemical and biological treatments that risk damaging the tissue and pose a toxic threat to the recipient organism. The mechanical properties of the “cleaned” tissue, the immunoresponse that provokes and its capacity for recellularization will be studied 'in vitro' and related to the amounts and type of remnant lipid compounds.

The project brings supercritical fluid technology into the biomedical field. This work will lead to efficient methodologies to “clean” all kind of organs/soft tissue and will enable safe animal-to-human transplantation, a current dream that will increase the hope of critical patients and improve life-quality after transplantation by removing the need of immunosuppression.

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The information about "CRITICLEAN" are provided by the European Opendata Portal: CORDIS opendata.

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