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TELOSPERM TERMINATED

Sperm telomere length as a mediator of paternal effects

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "TELOSPERM" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EXETER 

Organization address
address: THE QUEEN'S DRIVE NORTHCOTE HOUSE
city: EXETER
postcode: EX4 4QJ
website: www.ex.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2020-10-24

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EXETER UK (EXETER) coordinator 195˙454.00

Map

 Project objective

Despite having long been overlooked, paternal effects (influence of fathers on offspring traits via mechanisms other than the transmission of alleles) are now recognized as affecting a broad range of phenotypic traits in the next generation. There is, for example, increasing evidence for transgenerational effects of paternal stress levels with consequences on offspring health. In most cases, the proximate mechanism mediating these paternal effects on offspring remains unknown. Recent studies show that these transgenerational effects might be mediated, at least in part, by telomere attrition. Telomeres are regions of non-coding DNA at the end of eukaryotic chromosomes. Telomeres shorten at each cell division or when cells are exposed to oxidative stress, resulting in telomere shortening with aging. A permanent arrest in the cell cycle occurs when telomeres are shortened to a critical length, thereby increasing risk factors in a large number of diseases. Consequently, telomere length predicts remaining lifespan, with individuals with the shortest telomeres displaying the poorest survival prospects. Telomeres are very sensitive to damage induced by oxidative stress and paternal exposure to stressors may thus affect telomere length in sperm before fertilization as well as inherited by the offspring, with consequences for aging and disease susceptibility. In this project, I propose to test this hypothesis by examining the three following aims using a captive population of zebra finches (Taeniopygia guttata): • Measure the effect of stress exposure on sperm telomere length through an experimental manipulation of stress levels at the time of sperm production. • Determine links between paternal sperm telomere length and offspring telomere length at birth using artificial insemination experiments. • Elucidate the effects of sperm telomere length on offspring development and disease susceptibility.

 Publications

year authors and title journal last update
List of publications.
2019 GIRAUDEAU Mathieu, ANGELIER Frederic and SEPP Tuul
Are telomeres mediators between environmental conditions and pace-of-life strategies within the organism’s life and over generations?
published pages: , ISSN: 0265-9247, DOI:
BioEssays 2019-04-18

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