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PhoRAu TERMINATED

Photochemistry and radiolabelling of gold(III) anticancer prodrugs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PhoRAu project word cloud

Explore the words cloud of the PhoRAu project. It provides you a very rough idea of what is the project "PhoRAu" about.

bases    therapy    molecules    phototherapy    light    class    guided    reported    strikingly    advantages    organs    agents    tissues    cells    pet    integration    dark    reducing    ideal    cell    transition    remarkable    treatment    activated    imaging    undergo    labelling    antiproliferative    photodynamic    tomography    exploring    gold    anticancer    emission    metals    giving    modes    plan    photophysical    physiological    prodrugs    killing    drugs    cisplatin    nowadays    radionuclide    combining    attempt    derivatives    localised    shown    photoactivatable    chemical    reactivity    metal    124    synthesis    au    complexes    outstanding    chemotherapy    advantage    carbene    clinics    resistance    image    act    activate    simultaneously    mechanisms    temporal    medicinal    photochemical    versatility    photochemotherapy    cytotoxicity    world    irradiation    characterised    positron    offers    photochemistry    destruction    innovative    therapeutic    spatial    compartments    display    synthetic    stability    cancer   

Project "PhoRAu" data sheet

The following table provides information about the project.

Coordinator
FUNDACION DONOSTIA INTERNATIONAL PHYSICS CENTER 

Organization address
address: PASEO MANUEL LARDIZABAL 4
city: DONOSTIA SAN SEBASTIAN
postcode: 20018
website: http://dipc.ehu.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION DONOSTIA INTERNATIONAL PHYSICS CENTER ES (DONOSTIA SAN SEBASTIAN) coordinator 158˙121.00

Map

 Project objective

The use of light to activate anticancer prodrugs is nowadays a reality in clinics around the world. Photodynamic therapy is an effective treatment for the localised destruction of cancer cells in a range of tissues and organs. Triggering the antiproliferative activity of chemotherapy agents with spatial and temporal control offers the advantage of reducing side effects and resistance. On the bases of the great success of metal-based drugs (e.g. cisplatin and its derivatives), photoactivatable metal complexes have been investigated for their potential in light-activated therapy. This promising class of molecules is characterised by outstanding photophysical and photochemical features, which can result in novel cytotoxicity mechanisms. Among transition metals, gold has shown promising anticancer features, however no attempt to exploit Au photochemistry for medicinal use has been reported yet. This project aims at exploring such potential by investigating the development of innovative photoactivatable gold complexes that can be used as effective prodrugs for photochemotherapy and simultaneously act as imaging agents. In particular, the research plan involves the synthesis of novel gold(III) carbene complexes which display dark stability in physiological conditions and high reactivity under light irradiation. These systems can undergo controlled Au(III)/Au(I) reduction in cell compartments giving new cell killing modes and therapeutic advantages. Strikingly, their remarkable synthetic and chemical versatility are ideal for combining therapy and imaging capabilities through labelling with 124-I radionuclide for Positron Emission Tomography (PET). Integration of such features has the potential to deliver innovative image-guided agents for cancer phototherapy.

 Publications

year authors and title journal last update
List of publications.
2019 Alessio Terenzi, Hugo Gattuso, Angelo Spinello, Bernhard K. Keppler, Christophe Chipot, François Dehez, Giampaolo Barone, Antonio Monari
Targeting G-quadruplexes with Organic Dyes: Chelerythrine–DNA Binding Elucidated by Combining Molecular Modeling and Optical Spectroscopy
published pages: 472, ISSN: 2076-3921, DOI: 10.3390/antiox8100472
Antioxidants 8/10 2020-03-05
2019 Giovanni Salassa, Alessio Terenzi
Metal Complexes of Oxadiazole Ligands: An Overview
published pages: 3483, ISSN: 1422-0067, DOI: 10.3390/ijms20143483
International Journal of Molecular Sciences 20/14 2020-03-05

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