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NANOCANCER SIGNED

Getting new insights into the radio-sensitization effects of nanoparticles in photon and charged particle therapy

Total Cost €

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EC-Contrib. €

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Partnership

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 NANOCANCER project word cloud

Explore the words cloud of the NANOCANCER project. It provides you a very rough idea of what is the project "NANOCANCER" about.

nano    poor    radiation    tumor    innovative    therapeutic    enhanced    carlo    interdisciplinary    sensitizers    simulation    sensitization    performing    framework    enhancement    amplification    rt    microspectroscopy    first    photon    deeper    amplified    nanoparticles    ftir    purpose    monte    radio    radiotherapy    complementary    index    gd    np    physical    substantially    conventional    transform    glioma    insights    dose    atomic    full    au    nanocancer    local    particle    vibrational    time    damage    diseases    combining    biology    advantage    underlying    employed    strategy    cellular    killing    interaction    light    shown    multidisciplinary    macromolecules    therapy    fourier    biological    clear    effectiveness    action    mechanisms    standard    respect    transport    molecular    beams    radiobiology    realistic    damages    cell    prognosis    charged    spectroscopy    nanometre    tumour    infrared    seems    biochemical    breakthrough    cells    effect   

Project "NANOCANCER" data sheet

The following table provides information about the project.

Coordinator
CONSORCIO PARA LA CONSTRUCCION EQUIPAMIENTO Y EXPLOTACION DEL LABORATORIO DE LUZ SINCROTRON 

Organization address
address: CARRER DE LA LLUM 2-26
city: CERDANYOLA DEL VALLES BARCELONA
postcode: 8290
website: http://www.cells.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website https://www.cells.es/en/media/news/researchers-unveil-the-biochemical-effects-involved-in-nanoparticle-based-radiotherapy
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2017
 Duration (year-month-day) from 2017-10-30   to  2019-10-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSORCIO PARA LA CONSTRUCCION EQUIPAMIENTO Y EXPLOTACION DEL LABORATORIO DE LUZ SINCROTRON ES (CERDANYOLA DEL VALLES BARCELONA) coordinator 158˙121.00

Map

 Project objective

The use of high-atomic-number nanoparticles (NP) as tumour radio-sensitizers has been recently proposed as a breakthrough in radiotherapy (RT). Numerous biological studies have shown the enhanced effectiveness in tumor cell killing when NP were associated to photon RT and, more recently, to charged particle therapy. However, the mechanisms of action are not clear yet. In addition to the damage due to a possible local dose enhancement (physical effects), the interaction of NP with essential biological macromolecules could lead to changes in the cells (biochemical effects) leading to an amplified effect of the radiation. Within this framework, the main goal of the NANOCANCER project is to get deeper insights into the mechanisms underlying the amplification of radiation effects of NP. For this purpose, I will use a multidisciplinary strategy to evaluate both the biochemical and physical effects involved in these innovative nano-RT approaches. Vibrational spectroscopy (Fourier transform infrared, FTIR, microspectroscopy) will be employed for the first time to investigate the biochemical features in glioma cells combining two high-Z standard nanoparticles (Au and Gd) and charged particle beams. Physical effects will be also assessed by performing complementary Monte Carlo simulation of radiation transport, which will allow a realistic modelling of early biological damages induced by the radiation at the nanometre scale. This interdisciplinary proposal will be essential to better characterize the radio-sensitization effects of NP in glioma cells and, in addition, will bring light to the present charged particle therapy radiobiology, which seems to lead to substantially different tumour responses with respect to conventional RT at the cellular and molecular level. The knowledge of these biochemical features will help researchers to develop RT by taking full advantage of the underlying biology an enhance the therapeutic index of RT for diseases with poor prognosis.

 Publications

year authors and title journal last update
List of publications.
2019 I. Martínez-Rovira, O. Seksek, I. Yousef
A synchrotron-based infrared microspectroscopy study on the cellular response induced by gold nanoparticles combined with X-ray irradiations on F98 and U87-MG glioma cell lines
published pages: 6352-6364, ISSN: 0003-2654, DOI: 10.1039/c9an01109a
The Analyst 144/21 2019-12-16
2019 Immaculada Martínez-Rovira, Olivier Seksek, Josep Puxeu, Joan Gómez, Martin Kreuzer, Tanja Dučić, Maria Josep Ferreres, Manel Artigues, Ibraheem Yousef
Synchrotron-based infrared microspectroscopy study on the radiosensitization effects of Gd nanoparticles at megavoltage radiation energies
published pages: 5511-5520, ISSN: 0003-2654, DOI: 10.1039/C9AN00792J
The Analyst 144/18 2019-10-29

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The information about "NANOCANCER" are provided by the European Opendata Portal: CORDIS opendata.

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