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SENSHOR SIGNED

A Wearable Sensor for Hormones Based on a Native Microbial Sensing

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SENSHOR project word cloud

Explore the words cloud of the SENSHOR project. It provides you a very rough idea of what is the project "SENSHOR" about.

transfer    profile    women    give    disorders    protein    time    wearable    critical    contain    researcher    ultimate    isolated    fluorescence    connected    monitoring    usa    separate    dendrimers    exposure    polypeptides    france    signal    device    linked    perspective    environment    transcription    interdisciplinary    academic    energy    investigator    fluorescent    output    sense    identification    innovative    molecular    biosensor    monitor    bracelet    stress    entities    multiple    mood    sensitive    laboratories    insulin    polymer    compositions    organism    multidisciplinary    recording    biopolymers    prestigious    sweat    fret    play    hormones    interface    frontier    fellowship    odor    pressure    detection    electrical    resonance    microbial    mb    proposes    physiological    genetics    fertility    biology    combines    estradiol    beacons    spokesperson    functionalized    international    scientific    body    engineering    rhythms    responsible    career    roles    blood    optical    reproductive    emitted    biosensors    sensor    chemistry    nanoparticles    notable    hormone    human   

Project "SENSHOR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE BORDEAUX 

Organization address
address: PLACE PEY BERLAND 35
city: BORDEAUX
postcode: 33000
website: www.nouvelle-univ-bordeaux.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 264˙668 €
 EC max contribution 264˙668 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-GF
 Starting year 2017
 Duration (year-month-day) from 2017-03-15   to  2020-07-03

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE BORDEAUX FR (BORDEAUX) coordinator 264˙668.00
2    THE TRUSTEES OF BOSTON UNIVERSITY US (BOSTON MA) partner 0.00

Map

 Project objective

Connected devices that monitor human biology in real-time represent the next frontier in biosensors. Monitoring hormones is of significant interest as hormones play critical roles in multiple physiological processes including stress adaptation, blood pressure control, reproductive rhythms, and body odor. However, the real-time monitoring of hormones is challenging from a biology, chemistry, and engineering perspective, insulin detection being the one notable success. This project proposes to design a novel wearable device to sense estradiol (through sweat), a hormone responsible for fertility issues and mood disorders in women. This project is highly innovative and ambitious since it combines microbial genetics and protein identification, new polymer and nanoparticles compositions, and a novel sensor design. The wearable device (i.e., bracelet) will contain an optical-to-electrical interface for recording the fluorescence output of a biosensor, based on estradiol sensitive transcription factor isolated from a microbial organism. The biosensor is composed of biopolymers (dendrimers and polypeptides nanoparticles) functionalized with fluorescent molecular beacons (MB) and a hormone-sensitive transcription factor. Without the hormone, the two fluorescent entities of the MB are linked by the protein and no signal is emitted because of fluorescence resonance energy transfer (FRET), while in the presence of estradiol, the MB separate and a fluorescent signal is emitted. The project will be conducted in two international prestigious laboratories in France and in the USA to give to the applicant the best interdisciplinary scientific environment, and ensure the ultimate success of this project. The applicant will be the main spokesperson and lead investigator of the project. This international exposure and this fellowship will provide the applicant a unique and multidisciplinary profile, while facilitating her future academic career as a researcher in France.

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The information about "SENSHOR" are provided by the European Opendata Portal: CORDIS opendata.

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