Explore the words cloud of the NEURO-SWARM project. It provides you a very rough idea of what is the project "NEURO-SWARM" about.
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UNIVERSITY COLLEGE LONDON
|Coordinator Country||United Kingdom [UK]|
|Total cost||183˙454 €|
|EC max contribution||183˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-04-01 to 2019-05-01|
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|1||UNIVERSITY COLLEGE LONDON||UK (LONDON)||coordinator||183˙454.00|
Hearing in mosquitoes is crucial for mating partner recognition. Within mating swarms, males hear the wing beat of females and chase them to copulate. Despite the importance of this behaviour, very little is known about the molecular mechanisms involved. I and my co-workers have recently discovered an auditory efferent system innervating the mosquito hearing organ, the Johnston's Organ (JO) that releases the biogenic amines octopamine and serotonin and modulates the auditory function. However, we still do not know how this efferent system modulates hearing in the context of swarming. Given the intimate connection between hearing and swarming in mosquitoes, and considering that biogenic amines have been described in other insects to induce swarming, I hypothesize that biogenic amines induce mosquitoes to aggregate into swarms and upregulate their auditory sensitivity to increase male mosquito attraction to females. My objectives are to use a multidisciplinary approach, including molecular biology, physiological and behavioural methods, to study if biogenic amines increase the auditory sensitivity during swarming and to assess the potential of disrupting biogenic amine signalling to impair mosquito hearing and swarming. To this end, I will first study temporal variations of biogenic amine signalling pathways in the mosquito JO during the swarming period. I will then generate mosquito mutants to impair biogenic amine signalling and subsequently use these mutants to assess their auditory function and swarming behaviour phenotypes aiming at defining a direct involvement of biogenic amines in mosquito hearing and mating. We believe that our work will lead to developing novel mosquito control tools. Firstly, improving our knowledge on mosquito hearing can lead to develop novel acoustic traps. Secondly, the characterization of biogenic amine receptors could directly identify new insecticide targets. Thirdly, altering swarming behaviour can disrupt mosquito mating.
|year||authors and title||journal||last update|
Matthew P. Su, Marta AndrÃ©s, Nicholas Boyd-Gibbins, Jason Somers, Joerg T. Albert
Sex and species specific hearing mechanisms in mosquito flagellar ears
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06388-7
|Nature Communications 9/1||2019-09-25|
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