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HepatoPredict

A decision tool for Liver Transplantation based on molecular signature

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

HepatoPredict project word cloud

Explore the words cloud of the HepatoPredict project. It provides you a very rough idea of what is the project "HepatoPredict" about.

signature stage rely predictive healthcare exceeds disease patients sme validation rate liver patient lives curative 67 15 milan worldwide first intervention hence limits paramount biology unsuccessful select generating procedure markers option tumour transplants life diameter completion world ftes quality consequence global markets boost candidates stringent company successful clinical treatment decision instrument later biological commercialized additional transplant behavior transplantation 49 tools complete gain surrogate acute clinicians tool roi act 82 outcome predict background hepatocellular variables care powerful survival outmost organs criteria hepatopredict ophiomics hcc saved good cancer carcinoma mortality outside molecular optimization prognosis

Project "HepatoPredict" data sheet

The following table provides information about the project.

Coordinator	OPHIOMICS - INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA LDA Organization address address: RUA CUPERTINO DE MIRANDA N9 LOTE 8 POLO TECNOLOGICAO DE LISBOA city: LISBOA postcode: 1600 513 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Project website	http://phiomics.com/
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.3. (PRIORITY 'Societal challenges) 2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs) 3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
Code Call	H2020-SMEInst-2018-2020-1
Funding Scheme	SME-1
Starting year	2018
Duration (year-month-day)	from 2018-08-01 to 2018-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	OPHIOMICS - INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA LDA OPHIOMICS - INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA LDA Organization address address: RUA CUPERTINO DE MIRANDA N9 LOTE 8 POLO TECNOLOGICAO DE LISBOA city: LISBOA postcode: 1600 513 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	50˙000.00

Map

Project objective

Hepatocellular carcinoma (HCC) is a leading cause of cancer related mortality world-wide. The best curative treatment option is liver transplantation. The need for liver transplants for HCC by far exceeds the number of available organs, so stringent selection criteria are of paramount importance in order to ensure that the best candidates are selected for the procedure. So far, clinicians have to rely only on clinical variables to select transplant candidates for liver transplantation. The current criteria used (MILAN criteria) limits transplant to patients within specific parameters as tumour number and diameter, clearly related to disease and tumour biological behavior, but can only act as surrogate markers of tumour stage and biology. Hence, it is not possible to predict which patients outside the Milan criteria that would have a favourable prognosis. On this background, it is of outmost importance to gain access to better predictive tools that can provide decision support in selection for these patients. In response to this challenge, Ophiomics has developed a powerful predictive tool (HepatoPredict) based on molecular signature and clinical parameters, rather than only clinical variables. We can predict the good outcome of the intervention with a successful-curative rate of 82%, improving the Milan criteria one (67%). Unsuccessful liver transplantation will be avoided and, as a consequence, better survival rate and more saved lives will be achieved. Upon 5 years after the completion of the project, HepatoPredict will boost the growth of our company generating additional 15 FTEs and a ROI of 10.49. With the help of SME instrument, Ophiomics aims to complete the clinical validation and product optimization so that it can be commercialized across European markets first, and global markets later on, improving the quality of care of healthcare systems worldwide as well as the HCC patient´s quality of life.

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The information about "HEPATOPREDICT" are provided by the European Opendata Portal: CORDIS opendata.