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MICROS

Probing local ROS distributions in Calcium signaling microdomains after myocardial infarction

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MICROS project word cloud

Explore the words cloud of the MICROS project. It provides you a very rough idea of what is the project "MICROS" about.

imaging conceptual efficient species close expertise issue people physiology complexes quantitative organization oxidative an diagnose calcium gain cardiovascular heart luminescent combine nox2 ryanodine independent date reinforce oxygen molecular infarction weaker profile stress signaling remodeling laboratory domains skills host therapies local reactive hypertrophy ryr er qualify unable mechanism disciplinary ros structural global cellular poorly mishandling time decipher subsequent vicinity suffer quantify microdomains diseases competence arrhythmias potentially lethal researcher drastically contractility cardiomyocytes reverse probes public hampered mi health receptors underlying myocardial resolved functional cardiac ca2 lack dynamics

Project "MICROS" data sheet

The following table provides information about the project.

Coordinator	KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Project website	https://gbiomed.kuleuven.be/english/research/50000635/experimental_cardiology
Total cost	160˙800 €
EC max contribution	160˙800 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-07-18 to 2019-07-17

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	coordinator	160˙800.00

Map

Project objective

An increasing number of people suffer cardiovascular diseases and experience myocardial infarction (MI). The subsequent heart remodeling is characterized by weaker contractility, hypertrophy and lethal arrhythmias. The poorly-understood underlying mechanism is related to calcium (Ca2) mishandling in cardiomyocytes and oxidative stress. To date, most of the studies described global cellular processes and were unable to propose efficient therapies.

This work will decipher the structural and functional local organization of reactive oxygen species (ROS) at Ca2 signaling microdomains: at the vicinity of ryanodine receptors (RyR). Our knowledge is drastically hampered by the lack of local, quantitative and time-resolved ROS probes. We will thus combine the host laboratory competence in cardiac signaling and physiology, and the applicant expertise in ROS luminescent probes in order to quantify the RyR signaling domains remodeling through: (1) the measurement of local ROS production dynamics by NOX2 complexes, and (2) the imaging of the structural remodeling of the microdomains. This research will propose specific molecular targets to better diagnose and potentially reverse heart remodeling after infarction, contributing thus to solve a major public health issue in Europe.

The experienced researcher (ER) will gain new technical and conceptual skills in physiology which will reinforce her multi-disciplinary profile and qualify her to lead, in a close future, her independent research activity.

Publications

List of publications.
year	authors and title	journal	last update
2019	Chandan K. Nagaraju, Emma L. Robinson, Mouna Abdesselem, Sander Trenson, Eef Dries, Guillaume Gilbert, Stefan Janssens, Johan Van Cleemput, Filip Rega, Bart Meyns, H. Llewelyn Roderick, Ronald B. Driesen, Karin R. Sipido Myofibroblast Phenotype and Reversibility of Fibrosis in Patients With End-Stage Heart Failure published pages: 2267-2282, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2019.02.049	Journal of the American College of Cardiology 73/18	2020-01-21
2019	Chandan K. Nagaraju, Eef Dries, Guillaume Gilbert, Mouna Abdesselem, Nan Wang, Matthew Amoni, Ronald B. Driesen, Karin R. Sipido Myofibroblast modulation of cardiac myocyte structure and function published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-45078-2	Scientific Reports 9/1	2020-01-21

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