Opendata, web and dolomites

MICROS

Probing local ROS distributions in Calcium signaling microdomains after myocardial infarction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "MICROS" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website https://gbiomed.kuleuven.be/english/research/50000635/experimental_cardiology
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-07-18   to  2019-07-17

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 160˙800.00

Map

 Project objective

An increasing number of people suffer cardiovascular diseases and experience myocardial infarction (MI). The subsequent heart remodeling is characterized by weaker contractility, hypertrophy and lethal arrhythmias. The poorly-understood underlying mechanism is related to calcium (Ca2) mishandling in cardiomyocytes and oxidative stress. To date, most of the studies described global cellular processes and were unable to propose efficient therapies.

This work will decipher the structural and functional local organization of reactive oxygen species (ROS) at Ca2 signaling microdomains: at the vicinity of ryanodine receptors (RyR). Our knowledge is drastically hampered by the lack of local, quantitative and time-resolved ROS probes. We will thus combine the host laboratory competence in cardiac signaling and physiology, and the applicant expertise in ROS luminescent probes in order to quantify the RyR signaling domains remodeling through: (1) the measurement of local ROS production dynamics by NOX2 complexes, and (2) the imaging of the structural remodeling of the microdomains. This research will propose specific molecular targets to better diagnose and potentially reverse heart remodeling after infarction, contributing thus to solve a major public health issue in Europe.

The experienced researcher (ER) will gain new technical and conceptual skills in physiology which will reinforce her multi-disciplinary profile and qualify her to lead, in a close future, her independent research activity.

 Publications

year authors and title journal last update
List of publications.
2019 Chandan K. Nagaraju, Emma L. Robinson, Mouna Abdesselem, Sander Trenson, Eef Dries, Guillaume Gilbert, Stefan Janssens, Johan Van Cleemput, Filip Rega, Bart Meyns, H. Llewelyn Roderick, Ronald B. Driesen, Karin R. Sipido
Myofibroblast Phenotype and Reversibility of Fibrosis in Patients With End-Stage Heart Failure
published pages: 2267-2282, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2019.02.049
Journal of the American College of Cardiology 73/18 2020-01-21
2019 Chandan K. Nagaraju, Eef Dries, Guillaume Gilbert, Mouna Abdesselem, Nan Wang, Matthew Amoni, Ronald B. Driesen, Karin R. Sipido
Myofibroblast modulation of cardiac myocyte structure and function
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-45078-2
Scientific Reports 9/1 2020-01-21

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MICROS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MICROS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PARTOWNEU (2019)

The dark side of partial ownership and financial investment in Europe: What price to pay for consumers and society?

Read More  

SignEd.Math (2019)

Signs of Mathematics: Fostering the Emergence of Conceptual Gesture Among Deaf Students

Read More  

MAIRWEN (2019)

Mapping Argument Structure in Early Irish and Welsh

Read More