Explore the words cloud of the MICROS project. It provides you a very rough idea of what is the project "MICROS" about.
The following table provides information about the project.
KATHOLIEKE UNIVERSITEIT LEUVEN
|Coordinator Country||Belgium [BE]|
|Total cost||160˙800 €|
|EC max contribution||160˙800 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-07-18 to 2019-07-17|
Take a look of project's partnership.
|1||KATHOLIEKE UNIVERSITEIT LEUVEN||BE (LEUVEN)||coordinator||160˙800.00|
An increasing number of people suffer cardiovascular diseases and experience myocardial infarction (MI). The subsequent heart remodeling is characterized by weaker contractility, hypertrophy and lethal arrhythmias. The poorly-understood underlying mechanism is related to calcium (Ca2) mishandling in cardiomyocytes and oxidative stress. To date, most of the studies described global cellular processes and were unable to propose efficient therapies.
This work will decipher the structural and functional local organization of reactive oxygen species (ROS) at Ca2 signaling microdomains: at the vicinity of ryanodine receptors (RyR). Our knowledge is drastically hampered by the lack of local, quantitative and time-resolved ROS probes. We will thus combine the host laboratory competence in cardiac signaling and physiology, and the applicant expertise in ROS luminescent probes in order to quantify the RyR signaling domains remodeling through: (1) the measurement of local ROS production dynamics by NOX2 complexes, and (2) the imaging of the structural remodeling of the microdomains. This research will propose specific molecular targets to better diagnose and potentially reverse heart remodeling after infarction, contributing thus to solve a major public health issue in Europe.
The experienced researcher (ER) will gain new technical and conceptual skills in physiology which will reinforce her multi-disciplinary profile and qualify her to lead, in a close future, her independent research activity.
|year||authors and title||journal||last update|
Chandan K. Nagaraju, Emma L. Robinson, Mouna Abdesselem, Sander Trenson, Eef Dries, Guillaume Gilbert, Stefan Janssens, Johan Van Cleemput, Filip Rega, Bart Meyns, H. Llewelyn Roderick, Ronald B. Driesen, Karin R. Sipido
Myofibroblast Phenotype and Reversibility of Fibrosis in Patients With End-Stage Heart Failure
published pages: 2267-2282, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2019.02.049
|Journal of the American College of Cardiology 73/18||2020-01-21|
Chandan K. Nagaraju, Eef Dries, Guillaume Gilbert, Mouna Abdesselem, Nan Wang, Matthew Amoni, Ronald B. Driesen, Karin R. Sipido
Myofibroblast modulation of cardiac myocyte structure and function
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-45078-2
|Scientific Reports 9/1||2020-01-21|
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