Explore the words cloud of the AstroModulation project. It provides you a very rough idea of what is the project "AstroModulation" about.
The following table provides information about the project.
UNIVERSITY COLLEGE LONDON
|Coordinator Country||United Kingdom [UK]|
|Total cost||195˙454 €|
|EC max contribution||195˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-09-01 to 2019-08-31|
Take a look of project's partnership.
|1||UNIVERSITY COLLEGE LONDON||UK (LONDON)||coordinator||195˙454.00|
Evidence has been emerging for astrocytes to play an important role in neuronal cooperation and information processing in the brain. Recent work has suggested that their activity may even regulate the shape of action potentials in the axon and thus the efficacy of synaptic transmission. However, the underlying physiological machinery remains poorly understood. We propose here that astrocytes play an active role in the analogue-digital regulation of presynaptic signalling. To decipher the role of astroglia in presynaptic signalling, in particular analogue-digital axonal information transfer, we focus on the giant mossy-fibre-CA3 synapse, well characterized in the host laboratory. Our working hypothesis is that astrocytes regulate spike generation and propagation in axons by modulating local extracellular potassium and possibly by releasing glutamate. To test this hypothesis, an innovative set of technique will be used: i) direct recordings of astrocytes and either presynaptic or postsynaptic elements of the synapse in the mossy-fibre to CA3 synapse; ii) genetic tools allowing specific targeting and stimulation of either astrocytes or neurons; iii) pioneering imaging tools, such as FLIM, to directly measure the calcium entry and glutamate-sensing fluorescent reporter to reveal glutamate release by the astrocytes. The proposed project should unravel the mechanisms by which astrocytes control axonal information transfer in neural networks axonal excitability while shedding light on poorly understood features of astrocyte physiology.
|year||authors and title||journal||last update|
Christian Henneberger, Lucie Bard, Aude Panatier, James P. Reynolds, Nikolay I. Medvedev, Daniel Minge, Michel K. Herde, Stefanie Anders, Igor Kraev, Janosch P. Heller, Olga Kopach, Sylvain Rama, Kaiyu Zheng, Thomas P. Jensen, Inmaculada Sanchez-Romero, Harald Janovjak, Ole Petter Ottersen, Erlend Arnulf Nagelhus, Stephane H.R. Oliet, Michael G. Stewart, U. Valentin NÃ¤gerl, Dmitri A. Rusakov
LTP induction drives remodeling of astroglia to boost glutamate escape from synapses
published pages: , ISSN: , DOI: 10.1101/349233
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ASTROMODULATION" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "ASTROMODULATION" are provided by the European Opendata Portal: CORDIS opendata.
Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological ResponsesRead More
Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. ElegansRead More
Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and IconographyRead More