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EXO-EYE TERMINATED

Stem Cell-Derived Exosomes for the treatment of Traumatic and Degenerative Eye Disease

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "EXO-EYE" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 269˙857 €
 EC max contribution 269˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-GF
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 269˙857.00
2    United States Department of Health and Human Services US (Washington D.C.) partner 0.00

Map

 Project objective

The death and dysfunction of retinal ganglion cells (RGC) is a major cause of blindness in traumatic and degenerative ocular disease. For example, 60M people are affected by glaucoma with 4.5M becoming blind in both eyes, whilst optic neuritis affects 5/100,000 people and represents a significant problem for sufferers. RGC are the sole projection neurons and their axons make up the optic nerve, making them exquisitely sensitive to injury. As CNS neurons are irreplaceable, neuroprotective strategies are paramount to therapies aimed at preserving vision but as of yet, no such therapy exists. Current research has demonstrated significant neuroprotection by mesenchymal stem cells (MSC) including those from the bone marrow (BMSC), acting not as replacements for RGC but rather, as paracrine-mediated support cells. Clinical trials are already ongoing to test their efficacy in patients. Despite this, the exact mechanism behind their neuroprotective potential is not well understood. Recent studies have shown that exosomes, extracellular vesicles containing proteins, mRNA and miRNA may mediate much of the paracrine support offered by MSC and thus act as an easily purifiable cell-free alternative therapy for RGC neuroprotection. This proposal aims to assess the therapeutic efficacy of BMSC-derived exosomes, their characterisation and that of their RNA cargo. We will test these exosomes in animal models of traumatic (optic nerve crush) and degenerative (glaucoma) eye disease. Specifically, this proposal employs a novel strategy to promote RGC survival (relevant to ONC and glaucoma) and axon regeneration (relevant to optic nerve crush) through the use of exosomal delivery of mRNA/miRNA into injured RGC utilizing in vitro and in vivo injury models, RNAseq and CRISPR technology.

 Publications

year authors and title journal last update
List of publications.
2018 Ben Mead, Stanislav Tomarev
Retinal ganglion cell neuroprotection by growth factors and exosomes: lessons from mesenchymal stem cells
published pages: 228, ISSN: 1673-5374, DOI: 10.4103/1673-5374.226392
Neural Regeneration Research 13/2 2019-11-06
2018 Ben Mead, Juan Amaral, Stanislav Tomarev
Mesenchymal Stem Cell–Derived Small Extracellular Vesicles Promote Neuroprotection in Rodent Models of Glaucoma
published pages: 702, ISSN: 1552-5783, DOI: 10.1167/iovs.17-22855
Investigative Opthalmology & Visual Science 59/2 2019-11-06
2018 Ben Mead, Zubair Ahmed, Stanislav Tomarev
Mesenchymal Stem Cell–Derived Small Extracellular Vesicles Promote Neuroprotection in a Genetic DBA/2J Mouse Model of Glaucoma
published pages: 5473, ISSN: 1552-5783, DOI: 10.1167/iovs.18-25310
Investigative Opthalmology & Visual Science 59/13 2019-11-06

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The information about "EXO-EYE" are provided by the European Opendata Portal: CORDIS opendata.

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