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ARC-NeuroHet SIGNED

Unravelling neuronal heterogeneity in energy homeostasis regulation

Total Cost €

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EC-Contrib. €

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Partnership

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 ARC-NeuroHet project word cloud

Explore the words cloud of the ARC-NeuroHet project. It provides you a very rough idea of what is the project "ARC-NeuroHet" about.

food    nucleus    hormonal    energy    techniques    unravel    neuronal    diabetes    projections    adapt    curb    circuits    circuit    completion    markers    implicated    drugable    experimental    combine    obesity    maintenance    line    expression    plan    technologies    chronic    p2y6    glucose    reintegration    first    downstream    evidences    physiological    map    agrp    heterogeneity    prominent    arcuate    populations    recombinase    homeostasis    reinforce    subpopulation    hypothalamus    opportunity    participate    neurons    exceptional    nutrient    receptor    total    population    deregulation    strategies    location    expenditure    dissect    neuron    udp    independent    regulate    genetically    innovative    function    actual    facet    fellowship    molecular    systemic    dynamic    maturity    msca    regulation    balance    activators    insulin    activation    sub    axonal    unveil    professional    brain    intake    sensitivity    arc    diseases    signals    integrate    unknown    vivo    blood   

Project "ARC-NeuroHet" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 171˙460.00

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 Project objective

This MSCA Reintegration proposal is aimed to study the heterogeneity of neuronal populations implicated in the maintenance of energy balance. Because of their location, neurons in the arcuate nucleus of the hypothalamus (ARC) integrate nutrient and hormonal signals carried in the blood. Then, they regulate downstream neuron’s activity in order to adapt food intake and energy expenditure. Deregulation of energy homeostasis can lead to obesity and diabetes, two of the major chronic diseases in the EU. AgRP neurons, an ARC population, have a prominent role in the regulation of food intake and systemic insulin sensitivity. They establish axonal projections with several brain areas and recent evidences show that each sub-circuit can have a specific function in the regulation of food intake and/or glucose homeostasis. For this fellowship I propose to use an innovative experimental approach to investigate a specific novel AgRP neuronal subpopulation, characterized by the expression of the UDP-receptor, P2Y6, as a first step to unravel the heterogeneity of the total population. Although P2Y6 activation increases short-term food intake, its effects on glucose homeostasis are still unknown. I plan to combine new recombinase technologies with state of the art techniques to genetically identify the AgRP, P2Y6 subpopulation and then: 1) characterize their in vivo dynamic response to physiological activators; 2) map specific AgRP, P2Y6 sub-circuits and dissect their role in each facet of energy homeostasis; and 3) investigate new molecular markers, as possible drugable targets. Results from this project will unveil new aspects of neuronal heterogeneity that participate in the regulation of energy homeostasis and will contribute to design new strategies to curb the actual obesity trends. The completion of this MSCA fellowship represents an exceptional opportunity to reinforce my professional maturity and to develop my independent research line.

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