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ARC-NeuroHet SIGNED

Unravelling neuronal heterogeneity in energy homeostasis regulation

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ARC-NeuroHet project word cloud

Explore the words cloud of the ARC-NeuroHet project. It provides you a very rough idea of what is the project "ARC-NeuroHet" about.

chronic    reinforce    plan    reintegration    vivo    adapt    deregulation    insulin    blood    innovative    sensitivity    activation    neuron    obesity    neuronal    opportunity    maturity    subpopulation    glucose    nucleus    unveil    recombinase    participate    independent    populations    axonal    regulation    map    maintenance    sub    expenditure    agrp    circuit    combine    heterogeneity    markers    dissect    total    expression    neurons    diabetes    physiological    exceptional    projections    fellowship    msca    curb    techniques    experimental    location    hypothalamus    completion    circuits    implicated    unravel    strategies    diseases    arcuate    downstream    first    activators    brain    unknown    signals    intake    energy    homeostasis    drugable    line    nutrient    p2y6    facet    balance    evidences    food    integrate    regulate    receptor    udp    arc    technologies    prominent    actual    hormonal    genetically    function    systemic    professional    population    molecular    dynamic   

Project "ARC-NeuroHet" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 171˙460.00

Map

 Project objective

This MSCA Reintegration proposal is aimed to study the heterogeneity of neuronal populations implicated in the maintenance of energy balance. Because of their location, neurons in the arcuate nucleus of the hypothalamus (ARC) integrate nutrient and hormonal signals carried in the blood. Then, they regulate downstream neuron’s activity in order to adapt food intake and energy expenditure. Deregulation of energy homeostasis can lead to obesity and diabetes, two of the major chronic diseases in the EU. AgRP neurons, an ARC population, have a prominent role in the regulation of food intake and systemic insulin sensitivity. They establish axonal projections with several brain areas and recent evidences show that each sub-circuit can have a specific function in the regulation of food intake and/or glucose homeostasis. For this fellowship I propose to use an innovative experimental approach to investigate a specific novel AgRP neuronal subpopulation, characterized by the expression of the UDP-receptor, P2Y6, as a first step to unravel the heterogeneity of the total population. Although P2Y6 activation increases short-term food intake, its effects on glucose homeostasis are still unknown. I plan to combine new recombinase technologies with state of the art techniques to genetically identify the AgRP, P2Y6 subpopulation and then: 1) characterize their in vivo dynamic response to physiological activators; 2) map specific AgRP, P2Y6 sub-circuits and dissect their role in each facet of energy homeostasis; and 3) investigate new molecular markers, as possible drugable targets. Results from this project will unveil new aspects of neuronal heterogeneity that participate in the regulation of energy homeostasis and will contribute to design new strategies to curb the actual obesity trends. The completion of this MSCA fellowship represents an exceptional opportunity to reinforce my professional maturity and to develop my independent research line.

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