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AcTaferon

Revitalizing the clinical potential of type I IFNs in fighting influenza A virus infections with AcTaferon.

Total Cost €

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EC-Contrib. €

0

Partnership

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 AcTaferon project word cloud

Explore the words cloud of the AcTaferon project. It provides you a very rough idea of what is the project "AcTaferon" about.

uz    interdisciplinary    surface    antitumor    limited    actaferons    strategy    respectively    route    antiviral    viral    models    actaferon    huge    combining    ing    cells    offers    academic    viruses    eacute    expertise    health    body    mutant    influenza    unveils    pilot    background    ifns    recognizes    moiety    company    cancer    mortality    regulate    negatively    fusing    activated    influence    serious    marker    efficient    causing    opportunity    substantial    remained    sensitivity    effect    hence    receptor    doses    tackle    orionis    cellular    occasional    interferons    interferon    vitro    miracle    circumvents    site    infection    morbidity    pandemics    industrial    receptors    ifn    fundamental    cytokine    seasonal    preliminary    asset    broaden    vivo    concentration    limits    desired    epidemics    therapeutic    diseases    fight    based    too    obstacles    innovative    threat    transferred    intracellular    en    extend    saelens    clinical    affinity    regression    drug    binding    underscore    inactive    prof    drugs    co    severe    biological    tumor    pipeline    administrable   

Project "AcTaferon" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://www.cordis.europa.eu/project/rcn/209395_en.html
 Total cost 144˙230 €
 EC max contribution 144˙230 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 144˙230.00

Map

 Project objective

Based on their antiviral and antitumor effect, type I interferons (IFNs) were believed to be the miracle drug to tackle viruses and cancer. However, clinical IFN applications remained limited due to severe side effects resulting from widespread cellular sensitivity to IFN, which limits the administrable doses. Hence, the drug concentration at the desired infection or tumor site is often too low to be fully therapeutic efficient. AcTaferon (Activated-by-Targeting interferon), co-developed by Prof. Uzé, circumvents these obstacles. By fusing an IFN mutant with strongly reduced receptor binding affinity to a targeting moiety that recognizes a surface marker on specific cells, AcTaferon remains inactive “en route” through the body and unveils its biological activity only on specific target cells. Robust tumor regression without side effects and preliminary antiviral effects underscore the huge clinical potential of AcTaferon to fight cancer and viral diseases. By combining the AcTaferon and influenza expertise of Prof. Uzé and Prof. Saelens, respectively, this interdisciplinary project offers the opportunity to broaden the innovative AcTaferon therapeutic strategy from the cancer to the viral infection field. Influenza A was selected as a pilot target as seasonal influenza A epidemics and occasional pandemics remain a serious health threat causing substantial morbidity and mortality. Influenza A-targeted AcTaferons will be developed and analyzed in relevant in vitro and in vivo models. Eventually, all knowledge will be transferred to Orionis, a company that will implement the AcTaferon technology to develop novel drugs. My background on the intracellular processes that negatively regulate cytokine receptors and hence influence the cellular sensitivity to a (therapeutic) cytokine is an asset to this project. I will be able to extend my fundamental research experience with applied cytokine research, which may extend into a new academic or industrial research pipeline.

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The information about "ACTAFERON" are provided by the European Opendata Portal: CORDIS opendata.

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