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PRISM SIGNED

Psychiatric Ratings using Intermediate Stratified Markers - Sofia ref.: 115916

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PRISM" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://prism-project.eu
 Total cost 16˙195˙875 €
 EC max contribution 8˙080˙000 € (50%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2015-03-two-stage
 Funding Scheme IMI2-RIA
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2019-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 2˙105˙481.00
2    P1VITAL LIMITED UK (WALLINGFORD) participant 1˙226˙586.00
3    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 840˙250.00
4    STICHTING VUMC NL (AMSTERDAM) participant 775˙000.00
5    CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P. ES (MADRID) participant 678˙450.00
6    SBGNEURO LTD UK (THAME) participant 490˙500.00
7    BIOTRIAL FR (RENNES) participant 350˙000.00
8    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 334˙775.00
9    Concentris Research Management GmbH DE (Fürstenfeldbruck) participant 315˙000.00
10    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 286˙644.00
11    DRUG TARGET ID BV NL (NIJMEGEN) participant 200˙250.00
12    STICHTING BURO ECNP NL (UTRECHT) participant 168˙500.00
13    ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA IT (BOLOGNA) participant 100˙000.00
14    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 100˙000.00
15    THE UNIVERSITY OF EXETER UK (EXETER) participant 90˙000.00
16    EUROPESE FEDERATIE VAN FAMILIEVERENIGINGEN VAN PSYCHIATRISCH ZIEKE PERSONEN IVZW BE (LEUVEN) participant 18˙563.00
17    BOEHRINGER INGELHEIM INTERNATIONALGMBH DE (INGELHEIM) participant 0.00
18    Eli Lilly and Company Limited UK (Basingstoke) participant 0.00
19    F. HOFFMANN-LA ROCHE AG CH (BASEL) participant 0.00
20    JANSSEN PHARMACEUTICA NV BE (BEERSE) participant 0.00
21    NOVARTIS PHARMA AG CH (BASEL) participant 0.00
22    PFIZER LIMITED UK (SANDWICH) participant 0.00
23    TAKEDA DEVELOPMENT CENTRE EUROPE LTD UK (LONDON) participant 0.00

Map

 Project objective

The current nosology of neuropsychiatric disorders allows for a pragmatic approach to treatment choice, regulation and clinical research. However, without a biological rationale for these disorders, drug development has dramatically stagnated in the past decades. In a coordinated effort encompassing academic experts, SMEs, patient and family organizations, regulators, ECNP and EFPIA partners, this project aims to develop a quantitative biological approach to the understanding and classification of neuropsychiatric diseases to accelerate the discovery and development of better treatments for patients. This project will concentrate on Schizophrenia (SZ), Alzheimer’s disease (AD), and Major Depression (MD), as these disorders share part of their symptomatology, in particular social withdrawal and certain cognitive deficits, such as deficits in attention, working memory and sensory processing. By applying innovative technologies (e.g. EEG, cognitive tasks, (f)MRI, smartphone monitoring, and (epi-)genetics) to deep phenotype a clinical cohort of SZ and AD patients combined with a wider analysis of existing clinical data sets from major European and global disease cohorts that also include MD, we will define a set of quantifiable biological parameters best able to cluster and differentiate SZ, AD, and MD patients that do, or do not, exhibit social withdrawal. First, by mining large European SZ, AD and MD cohort datasets with already available social and cognitive proxy measures, and, second, by obtaining objective measures of social exploration levels (using a novel smartphone application), phenotypic relationships with social and cognitive measures will be further tested. For instance we might predict that socially withdrawn individuals may have lower cognitive functioning and poorer clinical course compared to those who are more socially engaged.

 Deliverables

List of deliverables.
Final press release Documents, reports 2020-04-08 20:57:19
Consensus report on pragmatic and ecological outcomes that will increase functionality and quality of life of those affected by the disorders studied published as a point of view paper in a scientific journal. Documents, reports 2020-04-08 20:57:19
Validation report on proxy indicators for cognitive deficits in patient cohorts. Documents, reports 2020-04-08 20:57:19
Presentation of PRISM findings to patients and their families Websites, patent fillings, videos etc. 2020-04-08 20:57:19
PRISM Communication material ready (leaflet, slides) Websites, patent fillings, videos etc. 2020-04-08 20:57:18
First quarterly electronic bulletins online Websites, patent fillings, videos etc. 2020-04-08 20:57:18
First press release Websites, patent fillings, videos etc. 2020-04-08 20:57:18
Manuscript submission of review article on the selection of phenotyping methods Documents, reports 2020-04-08 20:57:18
Final protocol Documents, reports 2020-04-08 20:57:18
Social withdrawal SOP disseminated to WP6 partners and workshop held Documents, reports 2020-04-08 20:57:18
Report on pre-selection of study designs, instruments and methodology for clinical and pre-clinical deep phenotyping Documents, reports 2020-04-08 20:57:18
Consensus framework document on final selection of study designs, instruments and methodology for clinical and pre- clinical deep phenotyping Documents, reports 2020-04-08 20:57:18
Go-online of the public project website Websites, patent fillings, videos etc. 2020-04-08 20:57:18
Data Management Plan Documents, reports 2020-04-08 20:57:18
Consensus framework document on selection of tools and instruments, and inclusion/exclusion criteria for clinical deep phenotyping Documents, reports 2020-04-08 20:57:18

Take a look to the deliverables list in detail:  detailed list of PRISM deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Raphaelle Winsky-Sommerer, Paula de Oliveira, Sally Loomis, Keith Wafford, Derk-Jan Dijk, Gary Gilmour
Disturbances of sleep quality, timing and structure and their relationship with other neuropsychiatric symptoms in Alzheimer’s disease and schizophrenia: Insights from studies in patient populations and animal models
published pages: 112-137, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.09.027
Neuroscience & Biobehavioral Reviews 97 2020-04-08
2019 J Bralten, CJHM Klemann, NR Mota, W De Witte, C Arango, C Fabbri, MJ Kas, N van der Wee, BWJH Penninx, A Serretti, B Franke, G Poelmans
Genetic underpinnings of sociability in the UK Biobank
published pages: , ISSN: , DOI:
2020-04-08
2018 Johnny Downs, Harry Dean, Suzannah Lechler, Nicola Sears, Rashmi Patel, Hitesh Shetty, Matthew Hotopf, Tamsin Ford, Marinos Kyriakopoulos, Covadonga M Diaz-Caneja, Celso Arango, James H MacCabe, Richard D Hayes, Laura Pina-Camacho
Negative Symptoms in Early-Onset Psychosis and Their Association With Antipsychotic Treatment Failure
published pages: 69-79, ISSN: 0586-7614, DOI: 10.1093/schbul/sbx197
Schizophrenia Bulletin 45/1 2020-04-08
2019 P. Danjou, G. Viardot, D. Maurice, P. Garcés, E.J. Wams, K.G. Phillips, V. Bertaina-Anglade, A.P. McCarthy, D.J. Pemberton
Electrophysiological assessment methodology of sensory processing dysfunction in schizophrenia and dementia of the Alzheimer type
published pages: 70-84, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.09.004
Neuroscience & Biobehavioral Reviews 97 2020-04-08
2019 Stefano Porcelli, Nic Van Der Wee, Steven van der Werff, Moji Aghajani, Jeffrey C. Glennon, Sabrina van Heukelum, Floriana Mogavero, Antonio Lobo, Francisco Javier Olivera, Elena Lobo, Mar Posadas, Juergen Dukart, Rouba Kozak, Estibaliz Arce, Arfan Ikram, Jacob Vorstman, Amy Bilderbeck, Ilja Saris, Martien J. Kas, Alessandro Serretti
Social brain, social dysfunction and social withdrawal
published pages: 10-33, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.09.012
Neuroscience & Biobehavioral Reviews 97 2020-04-08
2019 Martien J. Kas, Alessandro Serretti, Hugh Marston
Quantitative neurosymptomatics: Linking quantitative biology to neuropsychiatry
published pages: 1-2, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.11.013
Neuroscience & Biobehavioral Reviews 97 2020-04-08
2019 Tatiana Peleh, Xuesheng Bai, Martien J.H. Kas, Bastian Hengerer
RFID-supported video tracking for automated analysis of social behaviour in groups of mice
published pages: 108323, ISSN: 0165-0270, DOI: 10.1016/j.jneumeth.2019.108323
Journal of Neuroscience Methods 325 2020-04-08
2019 Nic. J.A. van der Wee, Amy C. Bilderbeck, Maria Cabello, Jose L. Ayuso-Mateos, Ilja M.J. Saris, Erik J. Giltay, Brenda W.J.H. Penninx, Celso Arango, Anke Post, Stefano Porcelli
Working definitions, subjective and objective assessments and experimental paradigms in a study exploring social withdrawal in schizophrenia and Alzheimer’s disease
published pages: 38-46, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.06.020
Neuroscience & Biobehavioral Reviews 97 2020-04-08
2019 Gary Gilmour, Stefano Porcelli, Valérie Bertaina-Anglade, Estibaliz Arce, Juergen Dukart, Anja Hayen, Antonio Lobo, Raul Lopez-Anton, Emilio Merlo Pich, Darrel J. Pemberton, Martha N. Havenith, Jeffrey C. Glennon, Brian T. Harel, Gerard Dawson, Hugh Marston, Rouba Kozak, Alessandro Serretti
Relating constructs of attention and working memory to social withdrawal in Alzheimer’s disease and schizophrenia: issues regarding paradigm selection
published pages: 47-69, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.09.025
Neuroscience & Biobehavioral Reviews 97 2020-04-08
2019 Amy C. Bilderbeck, Brenda W.J.H. Penninx, Celso Arango, Nic van der Wee, René Kahn, Inge Winter-van Rossum, Anja Hayen, Martien J. Kas, Anke Post, Gerard R. Dawson
Overview of the clinical implementation of a study exploring social withdrawal in patients with schizophrenia and Alzheimer’s disease
published pages: 87-93, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.06.019
Neuroscience & Biobehavioral Reviews 97 2020-04-08
2018 Maria Bove, Kevin Ike, Adriaan Eldering, Bauke Buwalda, Sietse F. de Boer, Maria Grazia Morgese, Stefania Schiavone, Vincenzo Cuomo, Luigia Trabace, Martien J.H. Kas
The Visible Burrow System: A behavioral paradigm to assess sociability and social withdrawal in BTBR and C57BL/6J mice strains
published pages: 9-19, ISSN: 0166-4328, DOI: 10.1016/j.bbr.2018.02.003
Behavioural Brain Research 344 2020-04-08
2018 Betty E. Hornix, Robbert Havekes, Martien J.H. Kas
Multisensory cortical processing and dysfunction across the neuropsychiatric spectrum
published pages: pending, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.02.010
Neuroscience & Biobehavioral Reviews 2018 Feb 26. pii: S0149-7634(17 2020-04-08
2017 Hugh Marston
Depression, schizophrenia may become redundant terms
published pages: N/A, ISSN: , DOI:
Horizon Magazine N/A 2020-04-08
2017 Hugh Marston
The PRISM project - measuring quantitative biology
published pages: N/A, ISSN: , DOI:
Big Data in Neurophysiology N/A 2020-04-08
2017 Julia H. Harari, Covadonga M. Díaz-Caneja, Joost Janssen, Kenia Martínez, Bárbara Arias, Celso Arango
The association between gene variants and longitudinal structural brain changes in psychosis: a systematic review of longitudinal neuroimaging genetics studies
published pages: , ISSN: 2334-265X, DOI: 10.1038/s41537-017-0036-2
npj Schizophrenia 3/1 2020-04-08
2017 I. M. J. Saris, M. Aghajani, S. J. A. van der Werff, N. J. A. van der Wee, B. W. J. H. Penninx
Social functioning in patients with depressive and anxiety disorders
published pages: 352-361, ISSN: 0001-690X, DOI: 10.1111/acps.12774
Acta Psychiatrica Scandinavica 136/4 2020-04-08
2017 Martien J. Kas, Brenda Penninx, Bernd Sommer, Alessandro Serretti, Celso Arango, Hugh Marston
A quantitative approach to neuropsychiatry: The why and the how
published pages: pending, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2017.12.008
Neuroscience & Biobehavioral Reviews 2017 Dec 12. pii: S0149-7634(17 2020-04-08

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