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MechaniChiral SIGNED

Mechanical Chirality: Synthesis, Properties and Applications at a New Horizon in Supramolecular Stereochemistry

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EC-Contrib. €

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Project "MechaniChiral" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF SOUTHAMPTON 

Organization address
address: Highfield
city: SOUTHAMPTON
postcode: SO17 1BJ
website: http://www.southampton.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙998˙927 €
 EC max contribution 1˙998˙927 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF SOUTHAMPTON UK (SOUTHAMPTON) coordinator 1˙998˙927.00

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 Project objective

Molecular chirality is a central theme in chemistry; in 2015 approximately 13% of publications in J. Am. Chem. Soc. and 12% in Angew. Chem. concerned chirality. All previously studied forms of molecular asymmetry (central, axial, planar and helical chirality) have found applications throughout the sub-disciplines of chemistry including as catalysts, materials and sensors.

Mechanically chiral rotaxanes are molecules in which the mechanical bond between a macrocycle and dumbbell-shaped component is the source of asymmetry rather than the covalent structure of the components themselves. These unusual molecules represent a novel and unexplored chiral supramolecular environment as the lack of a scalable synthetic approach for their isolation in enantiopure form has prevented all but the most cursory investigation of their properties. Thus, mechanical chirality remains an unexplored frontier of molecular asymmetry with the potential to deliver novel functions and impact across a range of chemical disciplines from materials chemistry to the synthesis of pharmaceutically active compounds.

The Goldup Group has recently demonstrated the first practical method for the synthesis of enantiopure mechanically chiral rotaxanes using a flexible active template methodology and thus the stage is finally set for the study and exploitation of this novel form of supramolecular asymmetry. Within the period of this ERC Consolidator Grant the PI will lead a team to investigate the synthesis, properties and applications of these intriguing mechanically chiral molecules.

 Publications

year authors and title journal last update
List of publications.
2019 Florian Modicom, Ellen M. G. Jamieson, Elise Rochette, Stephen M. Goldup
Chemical Consequences of the Mechanical Bond: A Tandem Active Template-Rearrangement Reaction
published pages: 3875-3879, ISSN: 1433-7851, DOI: 10.1002/anie.201813950
Angewandte Chemie International Edition 58/12 2019-12-16
2019 Mathieu Denis, James E.M. Lewis, Florian Modicom, Stephen M. Goldup
An Auxiliary Approach for the Stereoselective Synthesis of Topologically Chiral Catenanes
published pages: 1512-1520, ISSN: 2451-9294, DOI: 10.1016/j.chempr.2019.03.008
Chem 5/6 2019-12-16
2018 Mathieu Denis, Stephen Michael Goldup
A [3]Rotaxane Host Selects Between Stereoisomers
published pages: 4462-4464, ISSN: 1433-7851, DOI: 10.1002/anie.201800665
Angewandte Chemie International Edition 57/17 2019-12-16
2019 Martina Cirulli, Amanpreet Kaur, James E. M. Lewis, Zhihui Zhang, Jonathan A. Kitchen, Stephen M. Goldup, Maxie M. Roessler
Rotaxane-Based Transition Metal Complexes: Effect of the Mechanical Bond on Structure and Electronic Properties
published pages: 879-889, ISSN: 0002-7863, DOI: 10.1021/jacs.8b09715
Journal of the American Chemical Society 141/2 2019-12-16
2018 Mathieu Denis, Jessica Pancholi, Kajally Jobe, Michael Watkinson, Stephen M. Goldup
Chelating Rotaxane Ligands as Fluorescent Sensors for Metal Ions
published pages: 5408-5412, ISSN: 0044-8249, DOI: 10.1002/ange.201712931
Angewandte Chemie 130/19 2019-12-16
2019 Ellen M. G. Jamieson, Stephen M. Goldup
Chirality makes a move
published pages: 765-767, ISSN: 1755-4330, DOI: 10.1038/s41557-019-0320-z
Nature Chemistry 11/9 2019-12-16
2018 Valentina Bleve, Paola Franchi, Evangelia Konstanteli, Lorenzo Gualandi, Stephen M. Goldup, Elisabetta Mezzina, Marco Lucarini
Synthesis and Characterisation of a Paramagnetic [2]Rotaxane Based on a Crown Ether-Like Wheel Incorporating a Nitroxide Motif
published pages: 1198-1203, ISSN: 0947-6539, DOI: 10.1002/chem.201704969
Chemistry - A European Journal 24/5 2019-12-16
2017 T. H. Ngo, J. Labuta, G. N. Lim, W. A. Webre, F. D\'Souza, P. A. Karr, J. E. M. Lewis, J. P. Hill, K. Ariga, S. M. Goldup
Porphyrinoid rotaxanes: building a mechanical picket fence
published pages: 6679-6685, ISSN: 2041-6520, DOI: 10.1039/c7sc03165c
Chemical Science 8/9 2019-05-15
2018 James E. M. Lewis, Florian Modicom, Stephen M. Goldup
Efficient Multicomponent Active Template Synthesis of Catenanes
published pages: 4787-4791, ISSN: 0002-7863, DOI: 10.1021/jacs.8b01602
Journal of the American Chemical Society 140/14 2019-05-15
2018 Mathieu Denis, Lei Qin, Peter Turner, Katrina A. Jolliffe, Stephen M. Goldup
A Fluorescent Ditopic Rotaxane Ion-Pair Host
published pages: 5315-5319, ISSN: 1433-7851, DOI: 10.1002/anie.201713105
Angewandte Chemie International Edition 57/19 2019-05-15
2018 E. M. G. Jamieson, F. Modicom, S. M. Goldup
Chirality in rotaxanes and catenanes
published pages: 5266-5311, ISSN: 0306-0012, DOI: 10.1039/c8cs00097b
Chemical Society Reviews 47/14 2019-05-15
2018 Mathieu Denis, Jessica Pancholi, Kajally Jobe, Michael Watkinson, Stephen M. Goldup
Chelating Rotaxane Ligands as Fluorescent Sensors for Metal Ions
published pages: 5310-5314, ISSN: 1433-7851, DOI: 10.1002/anie.201712931
Angewandte Chemie International Edition 57/19 2019-05-15
2018 Michael A. Jinks, Alberto de Juan, Mathieu Denis, Catherine J. Fletcher, Marzia Galli, Ellen M. G. Jamieson, Florian Modicom, Zhihui Zhang, Stephen M. Goldup
Stereoselective Synthesis of Mechanically Planar Chiral Rotaxanes
published pages: 14806-14810, ISSN: 1433-7851, DOI: 10.1002/anie.201808990
Angewandte Chemie International Edition 57/45 2019-05-15

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