Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. fatemapb

FatemapB SIGNED

High Resolution Mapping of Fetal and Adult B Cell Fates During Ontogeny

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 FatemapB project word cloud

Explore the words cloud of the FatemapB project. It provides you a very rough idea of what is the project "FatemapB" about.

fundamental    science    ultimately    leukemogenesis    technologies    time    functionally    resolution    hematopoietic    switch    previously    inducible    generating    situ    utility    binding    replenished    normal    life    hematopoiesis    window    stem    herein    molecular    fates    mechanism    unattainable    afforded    single    protein    lin28b    discovery    b2    bone    host    immune    combinatorial    age    regeneration    inducing    protection    cell    functions    barcoding    fetal    dissection    understand    emphasis    identity    provides    developmental    post    mature    cre    unclear    relationship    perspectives    vivo    2012    cells    b1a    fatemapb    surprisingly    mediated    complementary    function    division    sustain    disputed    cellular    mammalian    hspcs    tracing    extend    self    yuan    transcriptional    effector    lymphopoiesis    me    resolve    assessing    implications    quantitative    qualitative    marrow    progenitor    renewal    recombination    emerge    types    lineage    rna    et    clinical    mosaic    labor    repertoire    differentiation    limited    adult    stratify    al    contribution   

Project "FatemapB" data sheet

The following table provides information about the project.

Coordinator		 LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Sweden [SE]
 Total cost 1˙499˙905 €
 EC max contribution 1˙499˙905 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 1˙499˙905.00

Map

 Project objective

FateMapB aims to understand how the unique differentiation potential of fetal hematopoietic stem and progenitor cells (HSPCs) contribute to functionally distinct cell types of the adult immune system. While most immune cells are replenished by HSPCs through life, others emerge during a limited window in fetal life and sustain through self-renewal in situ. The lineage identity of fetal HSPCs, and the extent of their contribution to the adult immune repertoire remain surprisingly unclear. I previously identified the fetal specific RNA binding protein Lin28b as a post-transcriptional molecular switch capable of inducing fetal-like hematopoiesis in adult bone marrow HSPCs (Yuan et al. Science, 2012). This discovery has afforded me with unique perspectives on the formation of the mammalian immune system. The concept that the mature immune system is a mosaic of fetal and adult derived cell types is addressed herein with an emphasis on the B cell lineage. We will use two complementary lineage-tracing technologies to stratify the immune system as a function of developmental time, generating fundamental insight into the division of labor between fetal and adult HSPCs that ultimately provides effective host protection. Aim 1. Determine the qualitative and quantitative contribution of fetal HSPCs to the mature immune repertoire in situ through Cre recombination mediated lineage-tracing. Aim 2. Resolve the disputed lineage relationship between fetal derived B1a cells and adult derived B2 cells by single cell lineage-tracing using cellular barcoding in vivo. Aim 3. Characterize the mechanism and effector functions of Lin28b induced B1a cell development for assessing the clinical utility of inducible fetal-like lymphopoiesis. The implications of FateMapB extend beyond normal development to immune regeneration and age-related features of leukemogenesis. Finally, our combinatorial lineage-tracing approach enables dissection of cell fates with previously unattainable resolution.

 Publications

year authors and title journal last update
List of publications.
2018 Trine A Kristiansen, Stijn Vanhee, Joan Yuan
The influence of developmental timing on B cell diversity
published pages: , ISSN: 0952-7915, DOI: 		Current Opinion in Immunology 2019-06-06
2017 Dan Su, Stijn Vanhee, Rebeca Soria, Elin Jaensson Gyllenbäck, Linda M. Starnes, Martina Kubec Højfeldt, Gabriel K. Pedersen, Joan Yuan, and Jeremy A. Daniel
PTIP chromatin regulator controls development and activation of B cell subsets to license humoral immunity in mice
published pages: , ISSN: 0027-8424, DOI: 		PNAS 2019-06-06

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FATEMAPB" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FATEMAPB" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

OAlipotherapy (2018)

Long-retention liposomic drug-delivery for intra-articular osteoarthritis therapy

Read More  

CHIPTRANSFORM (2018)

On-chip optical communication with transformation optics

Read More  

QUAMAP (2019)

Quasiconformal Methods in Analysis and Applications

Read More