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FatemapB SIGNED

High Resolution Mapping of Fetal and Adult B Cell Fates During Ontogeny

Total Cost €

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EC-Contrib. €

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Partnership

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 FatemapB project word cloud

Explore the words cloud of the FatemapB project. It provides you a very rough idea of what is the project "FatemapB" about.

protein    2012    technologies    stratify    mammalian    mechanism    perspectives    host    vivo    identity    lymphopoiesis    renewal    understand    progenitor    cells    limited    qualitative    contribution    inducing    fetal    mediated    herein    adult    emphasis    clinical    afforded    transcriptional    resolution    resolve    window    self    function    implications    complementary    life    division    types    dissection    barcoding    hspcs    immune    fates    situ    labor    recombination    differentiation    switch    et    science    disputed    single    b2    b1a    utility    fatemapb    emerge    repertoire    al    fundamental    cellular    protection    combinatorial    inducible    me    hematopoietic    lin28b    surprisingly    mature    normal    cre    bone    assessing    molecular    regeneration    quantitative    unclear    cell    post    relationship    lineage    discovery    time    functionally    hematopoiesis    binding    effector    yuan    mosaic    rna    leukemogenesis    ultimately    sustain    age    unattainable    marrow    generating    stem    developmental    tracing    previously    extend    replenished    provides    functions   

Project "FatemapB" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙499˙905 €
 EC max contribution 1˙499˙905 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 1˙499˙905.00

Map

 Project objective

FateMapB aims to understand how the unique differentiation potential of fetal hematopoietic stem and progenitor cells (HSPCs) contribute to functionally distinct cell types of the adult immune system. While most immune cells are replenished by HSPCs through life, others emerge during a limited window in fetal life and sustain through self-renewal in situ. The lineage identity of fetal HSPCs, and the extent of their contribution to the adult immune repertoire remain surprisingly unclear. I previously identified the fetal specific RNA binding protein Lin28b as a post-transcriptional molecular switch capable of inducing fetal-like hematopoiesis in adult bone marrow HSPCs (Yuan et al. Science, 2012). This discovery has afforded me with unique perspectives on the formation of the mammalian immune system. The concept that the mature immune system is a mosaic of fetal and adult derived cell types is addressed herein with an emphasis on the B cell lineage. We will use two complementary lineage-tracing technologies to stratify the immune system as a function of developmental time, generating fundamental insight into the division of labor between fetal and adult HSPCs that ultimately provides effective host protection. Aim 1. Determine the qualitative and quantitative contribution of fetal HSPCs to the mature immune repertoire in situ through Cre recombination mediated lineage-tracing. Aim 2. Resolve the disputed lineage relationship between fetal derived B1a cells and adult derived B2 cells by single cell lineage-tracing using cellular barcoding in vivo. Aim 3. Characterize the mechanism and effector functions of Lin28b induced B1a cell development for assessing the clinical utility of inducible fetal-like lymphopoiesis. The implications of FateMapB extend beyond normal development to immune regeneration and age-related features of leukemogenesis. Finally, our combinatorial lineage-tracing approach enables dissection of cell fates with previously unattainable resolution.

 Publications

year authors and title journal last update
List of publications.
2018 Trine A Kristiansen, Stijn Vanhee, Joan Yuan
The influence of developmental timing on B cell diversity
published pages: , ISSN: 0952-7915, DOI:
Current Opinion in Immunology 2019-06-06
2017 Dan Su, Stijn Vanhee, Rebeca Soria, Elin Jaensson Gyllenbäck, Linda M. Starnes, Martina Kubec Højfeldt, Gabriel K. Pedersen, Joan Yuan, and Jeremy A. Daniel
PTIP chromatin regulator controls development and activation of B cell subsets to license humoral immunity in mice
published pages: , ISSN: 0027-8424, DOI:
PNAS 2019-06-06

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