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FatemapB SIGNED

High Resolution Mapping of Fetal and Adult B Cell Fates During Ontogeny

Total Cost €

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EC-Contrib. €

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Partnership

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 FatemapB project word cloud

Explore the words cloud of the FatemapB project. It provides you a very rough idea of what is the project "FatemapB" about.

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Project "FatemapB" data sheet

The following table provides information about the project.

Coordinator		 LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Sweden [SE]
 Total cost 1˙499˙905 €
 EC max contribution 1˙499˙905 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 1˙499˙905.00

Map

 Project objective

FateMapB aims to understand how the unique differentiation potential of fetal hematopoietic stem and progenitor cells (HSPCs) contribute to functionally distinct cell types of the adult immune system. While most immune cells are replenished by HSPCs through life, others emerge during a limited window in fetal life and sustain through self-renewal in situ. The lineage identity of fetal HSPCs, and the extent of their contribution to the adult immune repertoire remain surprisingly unclear. I previously identified the fetal specific RNA binding protein Lin28b as a post-transcriptional molecular switch capable of inducing fetal-like hematopoiesis in adult bone marrow HSPCs (Yuan et al. Science, 2012). This discovery has afforded me with unique perspectives on the formation of the mammalian immune system. The concept that the mature immune system is a mosaic of fetal and adult derived cell types is addressed herein with an emphasis on the B cell lineage. We will use two complementary lineage-tracing technologies to stratify the immune system as a function of developmental time, generating fundamental insight into the division of labor between fetal and adult HSPCs that ultimately provides effective host protection. Aim 1. Determine the qualitative and quantitative contribution of fetal HSPCs to the mature immune repertoire in situ through Cre recombination mediated lineage-tracing. Aim 2. Resolve the disputed lineage relationship between fetal derived B1a cells and adult derived B2 cells by single cell lineage-tracing using cellular barcoding in vivo. Aim 3. Characterize the mechanism and effector functions of Lin28b induced B1a cell development for assessing the clinical utility of inducible fetal-like lymphopoiesis. The implications of FateMapB extend beyond normal development to immune regeneration and age-related features of leukemogenesis. Finally, our combinatorial lineage-tracing approach enables dissection of cell fates with previously unattainable resolution.

 Publications

year authors and title journal last update
List of publications.
2018 Trine A Kristiansen, Stijn Vanhee, Joan Yuan
The influence of developmental timing on B cell diversity
published pages: , ISSN: 0952-7915, DOI: 		Current Opinion in Immunology 2019-06-06
2017 Dan Su, Stijn Vanhee, Rebeca Soria, Elin Jaensson Gyllenbäck, Linda M. Starnes, Martina Kubec Højfeldt, Gabriel K. Pedersen, Joan Yuan, and Jeremy A. Daniel
PTIP chromatin regulator controls development and activation of B cell subsets to license humoral immunity in mice
published pages: , ISSN: 0027-8424, DOI: 		PNAS 2019-06-06

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