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DUALITY TERMINATED

An Integrated Computational and Experimental Approach to Rapid Synthesis of Highly Selective Dual-Targeted HDAC/CK2, MMP2/CK2 Inhibitors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 DUALITY project word cloud

Explore the words cloud of the DUALITY project. It provides you a very rough idea of what is the project "DUALITY" about.

cell    chromatin    matrix    threonine    deacetylases    disease    proliferative    regulates    serious    chosen    metalloproteinases    inhibitors    networks    hdacs    techniques    anti    active    maintenance    drug    fragment    create    alternative    remove    dependent    crosstalks    resistance    multiple    therapies    histone    seek    constitutes    anticancer    genetic    signaling    acetylation    modulators    difficulties    serine    directed    inducing    ck2    mmps    traditional    mechanisms    acetyl    enzymes    computational    reverse    kinase    constitutively    diseases    expression    environment    gene    hdac1    family    groups    cancer    favorable    inhibition    extensive    viability    transcription    deacetylation    prevent    zn    epigenetic    progression    mmp2    synthesize    dual    synthesis    group    cellular    histones    condensation    repression    interesting    treatment    agents    cocktails    single    standard    interfering    selectivity    strategy    matrixins    tumor    apoptotic    aberrant   

Project "DUALITY" data sheet

The following table provides information about the project.

Coordinator
FUNDACION UNIVERSITARIA SAN PABLO-CEU 

Organization address
address: C ISAAC PERAL 58
city: MADRID
postcode: 28040
website: www.ceu.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-10   to  2020-04-09

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION UNIVERSITARIA SAN PABLO-CEU ES (MADRID) coordinator 170˙121.00

Map

 Project objective

Traditional drug design strategy based on a single target has serious difficulties in developing new therapies for diseases such as cancer. Cancer is a very complex multi-genetic disease that involves multiple crosstalks between signaling networks. The use of cocktails of various anticancer agents interfering with different mechanisms has been the standard treatment to prevent the problems of resistance. An alternative approach is to design multi-target modulators, directed to different disease mechanisms. That is the approach we have chosen for this project, where we seek to design, synthesize and evaluate new dual agents based on the inhibition of three enzymes involved in the development and progression of tumor processes: HDAC1, CK2 and MMP2. CK2 is a serine / threonine kinase that is constitutively active and essential for cell viability. Its proliferative and anti-apoptotic properties create a favorable cellular environment for tumor progression and maintenance and, therefore, constitutes an interesting target for the treatment of cancer. Acetylation/deacetylation of histones is one of the epigenetic mechanisms that regulates gene expression. HDACs (histone deacetylases) remove acetyl groups from histones, inducing condensation of chromatin and, therefore, the repression of gene transcription. For this reason, they are considered key targets to reverse aberrant epigenetic changes associated with cancer. Matrix metalloproteinases (MMPs), also called matrixins are another family of Zn-dependent enzymes. Our research group has extensive experience in the design and synthesis of inhibitors of MMP2 provided with high activity and, more importantly, high selectivity over other metalloproteinases. The design of multi-target modulators will be carried out making use of computational techniques and based on the previous experience of the group in the design and synthesis of inhibitors of these three targets through a fragment based process.

 Publications

year authors and title journal last update
List of publications.
2019 Rangasamy, Geronimo, Ortín, Coderch, Zapico, Ramos, de Pascual-Teresa
Molecular Imaging Probes Based on Matrix Metalloproteinase Inhibitors (MMPIs)
published pages: 2982, ISSN: 1420-3049, DOI: 10.3390/molecules24162982
Molecules 24/16 2020-03-06

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