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ToMeTuM SIGNED

Towards the Understanding a Metal-Tumour-Metabolism

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ToMeTuM" data sheet

The following table provides information about the project.

Coordinator
VYSOKE UCENI TECHNICKE V BRNE 

Organization address
address: ANTONINSKA 548/1
city: BRNO STRED
postcode: 601 90
website: www.vutbr.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 1˙377˙495 €
 EC max contribution 1˙377˙495 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VYSOKE UCENI TECHNICKE V BRNE CZ (BRNO STRED) coordinator 1˙377˙495.00

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 Project objective

A tumour cell uses both genetic and protein weapons in its development. Gaining a greater understanding of these lethal mechanisms is a key step towards developing novel and more effective treatments. Because the metal ion metabolism of a tumour cell is not fully understood, we will address the challenge of explaining the mechanisms of how a tumour cell copes both with essential metal ions and platinum based drugs. The metal-based mechanisms help a tumour to grow on one side and to protect itself against commonly used metal-based drugs. On the other side, the exact description of these mechanisms, which are being associated with multi-drug resistance occurrence and failure of a treatment, still remains unclear. We will reveal the mechanism of the as yet not understood biochemical and molecularly-biological relationships and correlations between metal ions and proteins in a tumour development revealing the way how to suppress the growth and development of a tumour and to markedly enhance the effectiveness of a treatment.

To achieve this goal, we will focus on metallothionein and its interactions with essential metals and metal-containing anticancer drugs (cisplatin, carboplatin, and oxaliplatin). Their actions will be monitored both in vitro and in vivo. For this purpose, we will optimize electrochemical, mass spectrometric and immune-based methods. Based on processing of data obtained, new carcinogenetic pathways will be sought on cell level and proved by genetic modifications of target genes. The discovered processes and the pathways found will then be tested on two animal experimental models mice bearing breast tumours (MCF-7 and 4T1) and MeLiM minipigs bearing melanomas.

The precise description of the tumour related pathways coping with metal ions based on metallothioneins will direct new highly effective treatment strategies. Moreover, the discovery of new carcinogenetic pathways will open a window for understanding of cancer formation and development.

 Publications

year authors and title journal last update
List of publications.
2019 Yazan Haddad, Vojtech Adam, Zbynek Heger
Rotamer Dynamics: Analysis of Rotamers in Molecular Dynamics Simulations of Proteins
published pages: 2062-2072, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2019.04.017
Biophysical Journal 116/11 2019-09-02
2019 Miguel Rodrigo, Hana Buchtelova, Ana Jimenez, Pavlina Adam, Petr Babula, Zbynek Heger, Vojtech Adam
Transcriptomic Landscape of Cisplatin-Resistant Neuroblastoma Cells
published pages: 235, ISSN: 2073-4409, DOI: 10.3390/cells8030235
Cells 8/3 2019-09-02
2019 Tereza Vaneckova, Lucie Vanickova, Michaela Tvrdonova, Adam Pomorski, Artur Krężel, Tomas Vaculovic, Viktor Kanicky, Marketa Vaculovicova, Vojtech Adam
Molecularly imprinted polymers coupled to mass spectrometric detection for metallothionein sensing
published pages: 224-229, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2019.01.089
Talanta 198 2019-09-02
2019 Lucie Vanickova, Roman Guran, Sándor Kollár, Gabriella Emri, Sona Krizkova, Tomas Do, Zbynek Heger, Ondrej Zitka, Vojtech Adam
Mass spectrometric imaging of cysteine rich proteins in human skin
published pages: 270-277, ISSN: 0141-8130, DOI: 10.1016/j.ijbiomac.2018.11.272
International Journal of Biological Macromolecules 125 2019-09-02
2019 Miguel Angel Merlos Rodrigo, Hana Buchtelova, Vivian de los Rios, José Ignacio Casal, Tomas Eckschlager, Jan Hrabeta, Marie Belhajova, Zbynek Heger, Vojtech Adam
Proteomic Signature of Neuroblastoma Cells UKF-NB-4 Reveals Key Role of Lysosomal Sequestration and the Proteasome Complex in Acquiring Chemoresistance to Cisplatin
published pages: 1255-1263, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.8b00867
Journal of Proteome Research 18/3 2019-08-05

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The information about "TOMETUM" are provided by the European Opendata Portal: CORDIS opendata.

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