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SODIUMMRI-4-EU

Unlocking the potential of ultrahigh field 23Na magnetic resonance to quantify tissue sodium content for probing viability of the heart: where physics, biology and medicine meet

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SODIUMMRI-4-EU project word cloud

Explore the words cloud of the SODIUMMRI-4-EU project. It provides you a very rough idea of what is the project "SODIUMMRI-4-EU" about.

edge    examined    resolution    cutting    leverage    vivo    elucidate    model    patients    entirely    inherent    validated    life    physiometabolic    capitalize    huge    mainstay    ischemic    limited    valuable    magnetic    ge    places    treatments    tissue    quantitative    diseases    gain    predictor    me    resonance    imaging    finely    mi    medicine    myocardial    pursue    outstanding    economic    23na    attack    capacity    content    cardiovascular    cad    socio    expertise    outcomes    invasive    b0    diagnosing    phenotyping    skills    individualised    patient    burden    infarction    observe    threatening    instrument    therapy    sodium    possibilities    progression    clinical    meet    physics    offset    diagnosis    revascularized    death    ultrahigh    designing    mri    interdisciplinary    cvds    heart    subjects    tool    revascularization    concentration    formed    coronary    60    barriers    applicability    artery    healthy    unlock    cvd    purpose    sensitivity    viability    eliminate   

Project "SODIUMMRI-4-EU" data sheet

The following table provides information about the project.

Coordinator
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) 

Organization address
address: ROBERT ROSSLE STRASSE 10
city: BERLIN
postcode: 13125
website: www.mdc-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) DE (BERLIN) coordinator 171˙460.00

Map

 Project objective

Cardiovascular diseases (CVD) are the leading cause of death with 60% of CVDs associated with coronary artery diseases (CAD). CAD is the major cause of myocardial infarction (MI), commonly known as heart attack, which can be life threatening and places a huge socio-economic burden on the EU. The most widely used therapy for CAD is revascularization, and myocardial viability is a determining factor and predictor for patient outcomes. Magnetic resonance imaging (MRI) has become a mainstay of clinical diagnosis, but so far has seen limited use in the study of the heart. Here I aim to unlock the potential of myocardial viability imaging with physiometabolic MRI to provide a new instrument for the diagnosis and assessment of therapy success of CAD. Therefore I propose a quantitative approach based on MRI of sodium (23Na) that will allow me to observe new features of the working heart, at a level of resolution that will be highly valuable in understanding, finely diagnosing, and designing treatments for CVD. To meet this goal I pursue the development of cutting edge sodium MRI technology. Its capacity for quantitative assessment of sodium tissue content will be validated in model systems and in healthy subjects. The clinical applicability of 23Na MRI for viability imaging will be examined in revascularized MI patients. For this purpose I will leverage the sensitivity gain inherent to ultrahigh field MRI (B0≥7.0 T), capitalize on my outstanding expertise in the field of physiometabolic MRI and build on my interdisciplinary skills formed around MRI physics. In this project, this expertise will be taken to the next level to elucidate the progression of sodium concentration in ischemic myocardial tissue. This research will eliminate the main barriers to the study of tissue viability and will open entirely new possibilities for non-invasive, in vivo phenotyping as a tool for individualised medicine tailored to offset a major socio-economic burden on the EU induced by CVD.

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The information about "SODIUMMRI-4-EU" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2024-03-19 6:35:13) correctly updated