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SODIUMMRI-4-EU

Unlocking the potential of ultrahigh field 23Na magnetic resonance to quantify tissue sodium content for probing viability of the heart: where physics, biology and medicine meet

Total Cost €

0

EC-Contrib. €

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Partnership

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 SODIUMMRI-4-EU project word cloud

Explore the words cloud of the SODIUMMRI-4-EU project. It provides you a very rough idea of what is the project "SODIUMMRI-4-EU" about.

patients    ischemic    outstanding    eliminate    coronary    unlock    attack    mi    pursue    physiometabolic    purpose    resonance    threatening    diagnosis    gain    viability    content    patient    socio    healthy    artery    cvd    me    valuable    capitalize    economic    entirely    model    concentration    mainstay    designing    possibilities    medicine    places    treatments    outcomes    heart    physics    interdisciplinary    myocardial    finely    tool    sensitivity    offset    resolution    ge    quantitative    meet    revascularized    clinical    predictor    observe    therapy    magnetic    ultrahigh    individualised    leverage    diseases    barriers    60    vivo    instrument    sodium    imaging    limited    subjects    life    capacity    mri    examined    burden    infarction    cutting    cvds    tissue    invasive    death    diagnosing    formed    elucidate    edge    huge    inherent    skills    23na    cad    applicability    expertise    phenotyping    revascularization    validated    cardiovascular    b0    progression   

Project "SODIUMMRI-4-EU" data sheet

The following table provides information about the project.

Coordinator
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) 

Organization address
address: ROBERT ROSSLE STRASSE 10
city: BERLIN
postcode: 13125
website: www.mdc-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) DE (BERLIN) coordinator 171˙460.00

Map

 Project objective

Cardiovascular diseases (CVD) are the leading cause of death with 60% of CVDs associated with coronary artery diseases (CAD). CAD is the major cause of myocardial infarction (MI), commonly known as heart attack, which can be life threatening and places a huge socio-economic burden on the EU. The most widely used therapy for CAD is revascularization, and myocardial viability is a determining factor and predictor for patient outcomes. Magnetic resonance imaging (MRI) has become a mainstay of clinical diagnosis, but so far has seen limited use in the study of the heart. Here I aim to unlock the potential of myocardial viability imaging with physiometabolic MRI to provide a new instrument for the diagnosis and assessment of therapy success of CAD. Therefore I propose a quantitative approach based on MRI of sodium (23Na) that will allow me to observe new features of the working heart, at a level of resolution that will be highly valuable in understanding, finely diagnosing, and designing treatments for CVD. To meet this goal I pursue the development of cutting edge sodium MRI technology. Its capacity for quantitative assessment of sodium tissue content will be validated in model systems and in healthy subjects. The clinical applicability of 23Na MRI for viability imaging will be examined in revascularized MI patients. For this purpose I will leverage the sensitivity gain inherent to ultrahigh field MRI (B0≥7.0 T), capitalize on my outstanding expertise in the field of physiometabolic MRI and build on my interdisciplinary skills formed around MRI physics. In this project, this expertise will be taken to the next level to elucidate the progression of sodium concentration in ischemic myocardial tissue. This research will eliminate the main barriers to the study of tissue viability and will open entirely new possibilities for non-invasive, in vivo phenotyping as a tool for individualised medicine tailored to offset a major socio-economic burden on the EU induced by CVD.

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The information about "SODIUMMRI-4-EU" are provided by the European Opendata Portal: CORDIS opendata.

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