Opendata, web and dolomites

srpabsotcpfaaieps SIGNED

Selective ribosome profiling and biochemistry studies on the co-translational protein folding and assembly in eukaryotic protein synthesis

Total Cost €


EC-Contrib. €






 srpabsotcpfaaieps project word cloud

Explore the words cloud of the srpabsotcpfaaieps project. It provides you a very rough idea of what is the project "srpabsotcpfaaieps" about.

translationally    prevalence    localized    bacteria    intersection    enzyme    expose    dependent    unravel    imply    powerful    synthesis    definition    initiates    translation    membrane    selective    gene    assisted    guide    chains    basic    collision    profiles    ribosome    fundamental    regulatory    interplay    random    near    machineries    differences    diffusing    underpinning    profiling    nascent    interaction    complexes    folded    resolution    act    organization    post    oligomeric    co    proteins    establishing    identification    critical    unexplored    biology    differing    cerevisiae    biochemistry    eukaryotes    subunits    breaking    bukau    protein    influencing    paradigm    model    rarity    dynamic    hubs    serp    ribosomes    ground    efficiency    depends    conceptually    suggests    shift    linked    lab    cells    laboratory    subunit    yeast    assembly    complemented    molecular    integration    drives    saccharomyces    residue    interactions    synthesized    folding    chaperone    largely    translational    final    constellations    natively    chain    chaperones    operons    impacts    timing    biological    supporting   

Project "srpabsotcpfaaieps" data sheet

The following table provides information about the project.


Organization address
postcode: 69117

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2022-03-01


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Biological activity of cells depends on timely production of natively folded proteins by powerful translation and folding machineries. At a critical regulatory intersection of translation and folding, ribosomes act as integration hubs coordinating chaperone, enzyme and membrane targeting factor activity, influencing folding. Final assembly of proteins into oligomeric complexes however, has long been considered post-translational and dependent on random collision of fully synthesized diffusing subunits. In a shift of paradigm, recent evidence from the Bukau laboratory now suggests that in bacteria, assembly initiates co-translationally assisted by chaperones, and gene organization into operons drives co-localized translation of complex subunits that impacts efficiency of assembly. Fundamental differences in eukaryotes such as rarity of operons and differing chaperone constellations imply a widely different folding and assembly biology, which remains largely unexplored. The selective ribosome profiling (SeRP) method, developed by the Bukau lab, now allows ground breaking identification and definition of dynamic interactions of nascent chains, at near-residue resolution. Using SeRP with supporting biochemistry, I will unravel the nascent chain molecular biology underpinning protein folding and assembly in yeast, Saccharomyces cerevisiae, a powerful model for studying the fundamental aspects of this biology. Specifically, I will establish (1) basic features and prevalence of co-translational protein assembly, (2) how chaperones guide co-translational protein folding to affect assembly. Subunit interaction profiles complemented by chaperone interaction profiles, will expose the timing and interplay of protein folding and assembly steps linked to protein synthesis, establishing a detailed conceptually new biology of complex assembly in eukaryotes.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SRPABSOTCPFAAIEPS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SRPABSOTCPFAAIEPS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MarshFlux (2020)

The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshes

Read More  

DiMaS (2019)

Retrospective genomic analyses of shortfin Mako shark (Isurus oxyrinchus) using DNA from archived jaws

Read More  

FOCUSIS (2020)

Focal volume Control Using Structured Illumination Sources

Read More