Opendata, web and dolomites

srpabsotcpfaaieps SIGNED

Selective ribosome profiling and biochemistry studies on the co-translational protein folding and assembly in eukaryotic protein synthesis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 srpabsotcpfaaieps project word cloud

Explore the words cloud of the srpabsotcpfaaieps project. It provides you a very rough idea of what is the project "srpabsotcpfaaieps" about.

folded    chain    translational    hubs    differing    integration    differences    gene    intersection    interaction    conceptually    timing    unexplored    chaperones    folding    eukaryotes    dynamic    laboratory    fundamental    near    ground    biological    subunits    critical    machineries    synthesis    model    resolution    basic    suggests    dependent    localized    definition    oligomeric    constellations    assembly    subunit    lab    expose    breaking    shift    identification    protein    post    translationally    initiates    translation    interplay    serp    synthesized    operons    unravel    final    rarity    underpinning    bukau    membrane    act    largely    drives    supporting    chaperone    residue    proteins    molecular    interactions    enzyme    bacteria    natively    biology    ribosomes    saccharomyces    paradigm    cells    yeast    organization    co    biochemistry    profiling    powerful    influencing    efficiency    chains    complexes    selective    diffusing    establishing    ribosome    nascent    assisted    cerevisiae    collision    regulatory    linked    imply    impacts    guide    depends    random    prevalence    profiles    complemented   

Project "srpabsotcpfaaieps" data sheet

The following table provides information about the project.

Coordinator
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG 

Organization address
address: SEMINARSTRASSE 2
city: HEIDELBERG
postcode: 69117
website: www.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2022-03-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) coordinator 171˙460.00

Map

 Project objective

Biological activity of cells depends on timely production of natively folded proteins by powerful translation and folding machineries. At a critical regulatory intersection of translation and folding, ribosomes act as integration hubs coordinating chaperone, enzyme and membrane targeting factor activity, influencing folding. Final assembly of proteins into oligomeric complexes however, has long been considered post-translational and dependent on random collision of fully synthesized diffusing subunits. In a shift of paradigm, recent evidence from the Bukau laboratory now suggests that in bacteria, assembly initiates co-translationally assisted by chaperones, and gene organization into operons drives co-localized translation of complex subunits that impacts efficiency of assembly. Fundamental differences in eukaryotes such as rarity of operons and differing chaperone constellations imply a widely different folding and assembly biology, which remains largely unexplored. The selective ribosome profiling (SeRP) method, developed by the Bukau lab, now allows ground breaking identification and definition of dynamic interactions of nascent chains, at near-residue resolution. Using SeRP with supporting biochemistry, I will unravel the nascent chain molecular biology underpinning protein folding and assembly in yeast, Saccharomyces cerevisiae, a powerful model for studying the fundamental aspects of this biology. Specifically, I will establish (1) basic features and prevalence of co-translational protein assembly, (2) how chaperones guide co-translational protein folding to affect assembly. Subunit interaction profiles complemented by chaperone interaction profiles, will expose the timing and interplay of protein folding and assembly steps linked to protein synthesis, establishing a detailed conceptually new biology of complex assembly in eukaryotes.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SRPABSOTCPFAAIEPS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SRPABSOTCPFAAIEPS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Drought (2020)

Drought coping strategies in southern Africa 1966-2016

Read More  

POSPORI (2019)

Polymer Optical Sensors for Prolonged Overseeing the Robustness of civil Infrastructures

Read More  

MAREITA (2018)

Mapping Remediation in Italian Literature Beyond the Digital Revolution

Read More