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CRYOSTEM SIGNED

Solvent free Cryopreservation of Hematopoietic Stem Cells

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "CRYOSTEM" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF WARWICK 

Organization address
address: Kirby Corner Road - University House
city: COVENTRY
postcode: CV4 8UW
website: www.warwick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2019-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF WARWICK UK (COVENTRY) coordinator 150˙000.00

Map

 Project objective

This proof of concept grant will revolutionise how bone marrow stem cells are cryopreserved by translating ERC-grant developed technology, inspired by how organisms survive in extreme cold temperatures. Bone marrow (haematopoietic) stem cells are used in life saving treatments, especially for blood cancers such as Leukaemia, but have potential for a wide range of diseases. The current method for storing stem cells involves addition of huge amounts of toxic organic solvents which leads to unwanted side-effects and not all the recovered cells are viable. There is also a rapidly growing market for stem-cell therapies, but with a major bottleneck being the logistics of transport: getting the cells from the (small number of) specialised production facilities to the patients, with minimum processing and within the cold chain. We have established strong preliminary data demonstrating an entirely new concept in cryopreservation based on the use of (patent pending) synthetic polymers, which can control ice formation and growth. These are inspired by how antifreeze proteins protect organisms which live in sub-zero environments, but with the advantages of being; Highly tuneable; Low toxicity; Scalable synthesis. This is backed up by demonstration of function in immortalised cell lines, and is ready to be applied to real biomedical problems. In this project we will obtain convincing data-sets demonstrating that our synthetic polymer can revolutionise the storage and transport of stem cells for current and emerging therapies. This will bring significant societal change through enabling new regenerative medicine therapies and bringing real commercial benefit by solving a supply chain challenge and improving on the current 50 year old method.

 Publications

year authors and title journal last update
List of publications.
2019 Christopher Stubbs, Trisha L. Bailey, Kathryn Murray, Matthew I. Gibson
Polyampholytes as Emerging Macromolecular Cryoprotectants
published pages: , ISSN: 1525-7797, DOI: 10.1021/acs.biomac.9b01053
Biomacromolecules 2019-11-07
2019 Caroline I. Biggs, Christopher Stubbs, Ben Graham, Alice E. R. Fayter, Muhammad Hasan, Matthew I. Gibson
Mimicking the Ice Recrystallization Activity of Biological Antifreezes. When is a New Polymer “Active”?
published pages: 1900082, ISSN: 1616-5187, DOI: 10.1002/mabi.201900082
Macromolecular Bioscience Volume19, Issue7 July 2019 2019-11-07
2019 Laura E. Wilkins, Muhammad Hasan, Alice E. R. Fayter, Caroline Biggs, Marc Walker, Matthew I. Gibson
Site-specific conjugation of antifreeze proteins onto polymer-stabilized nanoparticles
published pages: 2986-2990, ISSN: 1759-9954, DOI: 10.1039/c8py01719k
Polymer Chemistry 10/23 2019-11-07
2019 Trisha L. Bailey, Christopher Stubbs, Kathryn Murray, Ruben M. F. Tomás, Lucienne Otten, Matthew I. Gibson
Synthetically Scalable Poly(ampholyte) Which Dramatically Enhances Cellular Cryopreservation
published pages: 3104-3114, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.9b00681
Biomacromolecules 20/8 2019-11-07
2019 Collette S. Guy, Kathryn Murray, Matthew I. Gibson, Elizabeth Fullam
Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis
published pages: , ISSN: 1477-0520, DOI: 10.1039/c9ob02222h
Organic & Biomolecular Chemistry Org. Biomol. Chem., 2019, Advan 2019-11-07
2019 Ruben M. F. Tomás, Matthew I. Gibson
Optimization and Stability of Cell–Polymer Hybrids Obtained by “Clicking” Synthetic Polymers to Metabolically Labeled Cell Surface Glycans
published pages: 2726-2736, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.9b00478
Biomacromolecules 20/7 2019-11-07

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