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AgeConsolidate SIGNED

The Missing Link of Episodic Memory Decline in Aging: The Role of Inefficient Systems Consolidation

Total Cost €

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EC-Contrib. €

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Partnership

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Project "AgeConsolidate" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I OSLO 

Organization address
address: PROBLEMVEIEN 5-7
city: OSLO
postcode: 313
website: www.uio.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 1˙999˙481 €
 EC max contribution 1˙999˙481 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I OSLO NO (OSLO) coordinator 1˙999˙481.00

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 Project objective

Which brain mechanisms are responsible for the faith of the memories we make with age, whether they wither or stay, and in what form? Episodic memory function does decline with age. While this decline can have multiple causes, research has focused almost entirely on encoding and retrieval processes, largely ignoring a third critical process– consolidation. The objective of AgeConsolidate is to provide this missing link, by combining novel experimental cognitive paradigms with neuroimaging in a longitudinal large-scale attempt to directly test how age-related changes in consolidation processes in the brain impact episodic memory decline. The ambitious aims of the present proposal are two-fold: (1) Use recent advances in memory consolidation theory to achieve an elaborate model of episodic memory deficits in aging (2) Use aging as a model to uncover how structural and functional brain changes affect episodic memory consolidation in general The novelty of the project lies in the synthesis of recent methodological advances and theoretical models for episodic memory consolidation to explain age-related decline, by employing a unique combination of a range of different techniques and approaches. This is ground-breaking, in that it aims at taking our understanding of the brain processes underlying episodic memory decline in aging to a new level, while at the same time advancing our theoretical understanding of how episodic memories are consolidated in the human brain. To obtain this outcome, I will test the main hypothesis of the project: Brain processes of episodic memory consolidation are less effective in older adults, and this can account for a significant portion of the episodic memory decline in aging. This will be answered by six secondary hypotheses, with 1-3 experiments or tasks designated to address each hypothesis, focusing on functional and structural MRI, positron emission tomography data and sleep experiments to target consolidation from different angles.

 Publications

year authors and title journal last update
List of publications.
2018 Inge K. Amlien, Markus H. Sneve, Didac Vidal-Piñeiro, Kristine B. Walhovd, Anders M. Fjell
The Lifespan Trajectory of the Encoding-Retrieval Flip: A Multimodal Examination of Medial Parietal Cortex Contributions to Episodic Memory
published pages: 8666-8679, ISSN: 0270-6474, DOI: 10.1523/jneurosci.1702-17.2018
The Journal of Neuroscience 38/40 2020-01-27
2019 Anders M. Fjell, Markus H. Sneve, Donatas Sederevicius, Øystein Sørensen, Stine K. Krogsrud, Athanasia M. Mowinckel, Kristine B. Walhovd
Volumetric and microstructural regional changes of the hippocampus underlying development of recall performance after extended retention intervals
published pages: 100723, ISSN: 1878-9293, DOI: 10.1016/j.dcn.2019.100723
Developmental Cognitive Neuroscience 40 2020-01-27
2019 Inge K. Amlien, Markus H. Sneve, Didac Vidal-Piñeiro, Kristine B. Walhovd, Anders M. Fjell
Elaboration Benefits Source Memory Encoding Through Centrality Change
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-39999-1
Scientific Reports 9/1 2020-01-27
2019 Anders M Fjell, Øystein Sørensen, Inge K Amlien, David Bartrés-Faz, Didac Maciá Bros, Nikolaus Buchmann, Ilja Demuth, Christian A Drevon, Sandra Düzel, Klaus P Ebmeier, Ane-Victoria Idland, Tim C Kietzmann, Rogier Kievit, Simone Kühn, Ulman Lindenberger, Athanasia M Mowinckel, Lars Nyberg, Darren Price, Claire E Sexton, Cristina Solé-Padullés, Sara Pudas, Donatas Sederevicius, Sana Suri, G
Self-reported sleep relates to hippocampal atrophy across the adult lifespan – results from the Lifebrain consortium
published pages: , ISSN: 0161-8105, DOI: 10.1093/sleep/zsz280
Sleep 2020-01-27
2018 Didac Vidal-Piñeiro, Markus H Sneve, Lars H Nyberg, Athanasia M Mowinckel, Donatas Sederevicius, Kristine B Walhovd, Anders M Fjell
Maintained Frontal Activity Underlies High Memory Function Over 8 Years in Aging
published pages: , ISSN: 1047-3211, DOI: 10.1093/cercor/bhy177
Cerebral Cortex 2019-05-23
2017 Didac Vidal-Piñeiro, Markus H. Sneve, Andreas B. Storsve, James M. Roe, Kristine B. Walhovd, Anders M. Fjell
Neural correlates of durable memories across the adult lifespan: brain activity at encoding and retrieval
published pages: 20-33, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2017.08.017
Neurobiology of Aging 60 2019-05-23
2018 Espen Langnes, Didac Vidal-Piñeiro, Markus H Sneve, Inge K Amlien, Kristine B Walhovd, Anders M Fjell
Development and Decline of the Hippocampal Long-Axis Specialization and Differentiation During Encoding and Retrieval of Episodic Memories
published pages: , ISSN: 1047-3211, DOI: 10.1093/cercor/bhy209
Cerebral Cortex 2019-05-23
2018 Anders M Fjell, Chi-Hua Chen, Donatas Sederevicius, Markus H Sneve, Håkon Grydeland, Stine K Krogsrud, Inge Amlien, Lia Ferschmann, Hedda Ness, Line Folvik, Dani Beck, Athanasia M Mowinckel, Christian K Tamnes, René Westerhausen, Asta K Håberg, Anders M Dale, Kristine B Walhovd
Continuity and Discontinuity in Human Cortical Development and Change From Embryonic Stages to Old Age
published pages: , ISSN: 1047-3211, DOI: 10.1093/cercor/bhy266
Cerebral Cortex 2019-05-23
2018 Markus H Sneve, Håkon Grydeland, Marcello G P Rosa, Tomáš Paus, Tristan Chaplin, Kristine Walhovd, Anders M Fjell
High-Expanding Regions in Primate Cortical Brain Evolution Support Supramodal Cognitive Flexibility
published pages: , ISSN: 1047-3211, DOI: 10.1093/cercor/bhy268
Cerebral Cortex 2019-05-23

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The information about "AGECONSOLIDATE" are provided by the European Opendata Portal: CORDIS opendata.

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