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MABSTER SIGNED

Monoclonal Antibodies with Binding Sensitive To Environmental Regulation

Total Cost €

0

EC-Contrib. €

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Partnership

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 MABSTER project word cloud

Explore the words cloud of the MABSTER project. It provides you a very rough idea of what is the project "MABSTER" about.

techniques    tech    health    immunized    ph    2018    policy    scientific    anaphylaxis    middle    infectious    parasitic    antivenom    mutability    peptide    costly    opportunity    therapeutic    submitted    display    issue    pursuit    independently    harnessed    human    ways    dr    countries    victims    special    offers    unless    designing    disease    advisor    international    conventional    societal    neutralize    me    microarray    researcher    serum    regulation    diseases    income    million    discovery    am    patients    elusive    world    erc    manufacture    sensitive    ntd    biotherapeutics    phage    entirely    discovered    tropical    cross    antivenoms    german    types    fall    animals    snake    snakebite    cancer    dissertation    density    habilitation    led    group    envenoming    inflict    starting    toxins    engineering    organization    toxin    binding    hyper    area    antibody    antibodies    kills    ntds    consolidate    indications    time    monoclonal    gt    sickness    recyclable    microenvironment    reactive    broadly    grant   

Project "MABSTER" data sheet

The following table provides information about the project.

Coordinator		 DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Denmark [DK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 1˙500˙000.00

Map

 Project objective

Snakebite envenoming is a Neglected Tropical Disease (NTD) that each year affects 2.5 million victims and kills >100,000, unless they are treated with antivenom. Conventional antivenoms, derived from immunized animals, inflict serum sickness and anaphylaxis in patients, and are costly to manufacture. Monoclonal human antibodies with special toxin-binding properties that are sensitive towards regulation by their microenvironment (e.g. pH), which may be discovered using phage display selection, may solve this issue, providing significant societal impact by enabling the development of cost-effective antivenoms to victims in low and middle-income countries. In this project, phage display selection, high-density peptide microarray technology, and antibody engineering techniques will in three scientific objectives be harnessed in the pursuit of developing novel methodologies for discovery of therapeutic human monoclonal antibodies that are recyclable (can neutralize more than one snake toxin per antibody), broadly cross-reactive (can neutralize different types of snake toxins), and that are both broadly cross-reactive and recyclable at the same time. This will open up for entirely new ways of designing biotherapeutics against complex indications, such snakebite envenoming, but also cancer, infectious, and parasitic diseases, where the targets can be elusive due to hyper-mutability. The ERC Starting Grant offers a unique opportunity to consolidate me as an international key scientific researcher in this field of antibody discovery and NTDs. I have already independently led a research group in this area for 2 years, I have in-depth experience with toxin-targeted antibody discovery (my dr.tech dissertation similar to the German “habilitation” will be submitted during fall 2018), and I am already involved in high level policy in the field of snakebite envenoming via my role as a scientific advisor for the World Health Organization.

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The information about "MABSTER" are provided by the European Opendata Portal: CORDIS opendata.

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