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MABSTER SIGNED

Monoclonal Antibodies with Binding Sensitive To Environmental Regulation

Total Cost €

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EC-Contrib. €

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Partnership

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 MABSTER project word cloud

Explore the words cloud of the MABSTER project. It provides you a very rough idea of what is the project "MABSTER" about.

advisor    led    infectious    group    phage    ntds    reactive    independently    sickness    societal    disease    time    diseases    binding    income    regulation    monoclonal    tech    unless    victims    snake    consolidate    discovery    inflict    therapeutic    pursuit    erc    display    antivenom    envenoming    organization    kills    manufacture    antibodies    entirely    harnessed    antibody    biotherapeutics    2018    techniques    anaphylaxis    density    animals    microarray    international    scientific    million    cross    ntd    designing    toxins    ways    human    countries    researcher    submitted    costly    broadly    microenvironment    middle    indications    starting    types    habilitation    hyper    peptide    grant    dissertation    parasitic    me    sensitive    cancer    dr    area    snakebite    patients    ph    gt    mutability    serum    health    fall    discovered    policy    issue    special    world    elusive    offers    conventional    opportunity    toxin    am    neutralize    tropical    immunized    antivenoms    german    engineering    recyclable   

Project "MABSTER" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 1˙500˙000.00

Map

 Project objective

Snakebite envenoming is a Neglected Tropical Disease (NTD) that each year affects 2.5 million victims and kills >100,000, unless they are treated with antivenom. Conventional antivenoms, derived from immunized animals, inflict serum sickness and anaphylaxis in patients, and are costly to manufacture. Monoclonal human antibodies with special toxin-binding properties that are sensitive towards regulation by their microenvironment (e.g. pH), which may be discovered using phage display selection, may solve this issue, providing significant societal impact by enabling the development of cost-effective antivenoms to victims in low and middle-income countries. In this project, phage display selection, high-density peptide microarray technology, and antibody engineering techniques will in three scientific objectives be harnessed in the pursuit of developing novel methodologies for discovery of therapeutic human monoclonal antibodies that are recyclable (can neutralize more than one snake toxin per antibody), broadly cross-reactive (can neutralize different types of snake toxins), and that are both broadly cross-reactive and recyclable at the same time. This will open up for entirely new ways of designing biotherapeutics against complex indications, such snakebite envenoming, but also cancer, infectious, and parasitic diseases, where the targets can be elusive due to hyper-mutability. The ERC Starting Grant offers a unique opportunity to consolidate me as an international key scientific researcher in this field of antibody discovery and NTDs. I have already independently led a research group in this area for 2 years, I have in-depth experience with toxin-targeted antibody discovery (my dr.tech dissertation similar to the German “habilitation” will be submitted during fall 2018), and I am already involved in high level policy in the field of snakebite envenoming via my role as a scientific advisor for the World Health Organization.

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The information about "MABSTER" are provided by the European Opendata Portal: CORDIS opendata.

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