Opendata, web and dolomites

MABSTER SIGNED

Monoclonal Antibodies with Binding Sensitive To Environmental Regulation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MABSTER project word cloud

Explore the words cloud of the MABSTER project. It provides you a very rough idea of what is the project "MABSTER" about.

hyper    ntds    display    gt    scientific    tropical    unless    middle    ph    income    inflict    area    indications    issue    habilitation    antivenoms    recyclable    anaphylaxis    fall    discovery    monoclonal    time    starting    biotherapeutics    ways    societal    dissertation    engineering    antibody    independently    german    2018    harnessed    broadly    erc    mutability    toxins    neutralize    designing    diseases    cross    cancer    million    snakebite    patients    submitted    ntd    types    immunized    advisor    countries    human    group    special    animals    antibodies    microenvironment    kills    led    entirely    peptide    dr    elusive    am    offers    organization    victims    opportunity    tech    researcher    therapeutic    manufacture    disease    techniques    international    grant    snake    serum    policy    health    microarray    toxin    density    antivenom    discovered    world    costly    me    reactive    sensitive    regulation    pursuit    envenoming    sickness    binding    conventional    phage    consolidate    parasitic    infectious   

Project "MABSTER" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 1˙500˙000.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Snakebite envenoming is a Neglected Tropical Disease (NTD) that each year affects 2.5 million victims and kills >100,000, unless they are treated with antivenom. Conventional antivenoms, derived from immunized animals, inflict serum sickness and anaphylaxis in patients, and are costly to manufacture. Monoclonal human antibodies with special toxin-binding properties that are sensitive towards regulation by their microenvironment (e.g. pH), which may be discovered using phage display selection, may solve this issue, providing significant societal impact by enabling the development of cost-effective antivenoms to victims in low and middle-income countries. In this project, phage display selection, high-density peptide microarray technology, and antibody engineering techniques will in three scientific objectives be harnessed in the pursuit of developing novel methodologies for discovery of therapeutic human monoclonal antibodies that are recyclable (can neutralize more than one snake toxin per antibody), broadly cross-reactive (can neutralize different types of snake toxins), and that are both broadly cross-reactive and recyclable at the same time. This will open up for entirely new ways of designing biotherapeutics against complex indications, such snakebite envenoming, but also cancer, infectious, and parasitic diseases, where the targets can be elusive due to hyper-mutability. The ERC Starting Grant offers a unique opportunity to consolidate me as an international key scientific researcher in this field of antibody discovery and NTDs. I have already independently led a research group in this area for 2 years, I have in-depth experience with toxin-targeted antibody discovery (my dr.tech dissertation similar to the German “habilitation” will be submitted during fall 2018), and I am already involved in high level policy in the field of snakebite envenoming via my role as a scientific advisor for the World Health Organization.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MABSTER" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MABSTER" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

HyperCube (2020)

HyperCube: Gram scale production of ferrite nanocubes and thermo-responsive polymer coated nanocubes for medical applications and further exploitation in other hyperthermia fields

Read More  

inSight (2019)

Moving a novel gene therapy paradigm to treat blindness to the market

Read More  

MCS-MD (2019)

The Molecular Dynamics of Membrane Contact Sites

Read More