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MABSTER SIGNED

Monoclonal Antibodies with Binding Sensitive To Environmental Regulation

Total Cost €

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EC-Contrib. €

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Partnership

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 MABSTER project word cloud

Explore the words cloud of the MABSTER project. It provides you a very rough idea of what is the project "MABSTER" about.

density    cross    infectious    kills    pursuit    elusive    societal    income    consolidate    am    display    techniques    ways    unless    cancer    serum    ph    recyclable    opportunity    tech    policy    issue    manufacture    health    toxin    international    peptide    disease    grant    antibodies    me    time    countries    immunized    therapeutic    victims    world    starting    inflict    scientific    engineering    snake    million    group    organization    snakebite    mutability    designing    2018    microenvironment    entirely    hyper    advisor    conventional    gt    led    middle    researcher    broadly    antivenoms    independently    dissertation    ntds    indications    dr    antibody    human    anaphylaxis    offers    patients    sickness    submitted    types    special    erc    microarray    german    sensitive    area    ntd    habilitation    antivenom    fall    animals    parasitic    discovery    discovered    regulation    monoclonal    diseases    harnessed    neutralize    tropical    envenoming    phage    toxins    binding    costly    reactive    biotherapeutics   

Project "MABSTER" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 1˙500˙000.00

Map

 Project objective

Snakebite envenoming is a Neglected Tropical Disease (NTD) that each year affects 2.5 million victims and kills >100,000, unless they are treated with antivenom. Conventional antivenoms, derived from immunized animals, inflict serum sickness and anaphylaxis in patients, and are costly to manufacture. Monoclonal human antibodies with special toxin-binding properties that are sensitive towards regulation by their microenvironment (e.g. pH), which may be discovered using phage display selection, may solve this issue, providing significant societal impact by enabling the development of cost-effective antivenoms to victims in low and middle-income countries. In this project, phage display selection, high-density peptide microarray technology, and antibody engineering techniques will in three scientific objectives be harnessed in the pursuit of developing novel methodologies for discovery of therapeutic human monoclonal antibodies that are recyclable (can neutralize more than one snake toxin per antibody), broadly cross-reactive (can neutralize different types of snake toxins), and that are both broadly cross-reactive and recyclable at the same time. This will open up for entirely new ways of designing biotherapeutics against complex indications, such snakebite envenoming, but also cancer, infectious, and parasitic diseases, where the targets can be elusive due to hyper-mutability. The ERC Starting Grant offers a unique opportunity to consolidate me as an international key scientific researcher in this field of antibody discovery and NTDs. I have already independently led a research group in this area for 2 years, I have in-depth experience with toxin-targeted antibody discovery (my dr.tech dissertation similar to the German “habilitation” will be submitted during fall 2018), and I am already involved in high level policy in the field of snakebite envenoming via my role as a scientific advisor for the World Health Organization.

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The information about "MABSTER" are provided by the European Opendata Portal: CORDIS opendata.

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