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MABSTER SIGNED

Monoclonal Antibodies with Binding Sensitive To Environmental Regulation

Total Cost €

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EC-Contrib. €

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Partnership

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 MABSTER project word cloud

Explore the words cloud of the MABSTER project. It provides you a very rough idea of what is the project "MABSTER" about.

antibody    group    erc    antivenom    therapeutic    toxin    policy    inflict    entirely    international    pursuit    envenoming    fall    advisor    million    types    display    recyclable    cross    ways    societal    issue    snakebite    ntd    immunized    harnessed    countries    organization    sensitive    disease    dr    area    grant    scientific    monoclonal    2018    serum    independently    neutralize    human    engineering    world    techniques    researcher    conventional    phage    discovery    manufacture    led    animals    designing    costly    offers    victims    elusive    am    binding    cancer    snake    gt    microarray    broadly    parasitic    infectious    mutability    me    kills    german    middle    time    ntds    submitted    regulation    income    hyper    antibodies    antivenoms    discovered    health    reactive    patients    ph    peptide    dissertation    toxins    tech    tropical    unless    habilitation    anaphylaxis    opportunity    sickness    consolidate    special    biotherapeutics    diseases    density    starting    indications    microenvironment   

Project "MABSTER" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 1˙500˙000.00

Map

 Project objective

Snakebite envenoming is a Neglected Tropical Disease (NTD) that each year affects 2.5 million victims and kills >100,000, unless they are treated with antivenom. Conventional antivenoms, derived from immunized animals, inflict serum sickness and anaphylaxis in patients, and are costly to manufacture. Monoclonal human antibodies with special toxin-binding properties that are sensitive towards regulation by their microenvironment (e.g. pH), which may be discovered using phage display selection, may solve this issue, providing significant societal impact by enabling the development of cost-effective antivenoms to victims in low and middle-income countries. In this project, phage display selection, high-density peptide microarray technology, and antibody engineering techniques will in three scientific objectives be harnessed in the pursuit of developing novel methodologies for discovery of therapeutic human monoclonal antibodies that are recyclable (can neutralize more than one snake toxin per antibody), broadly cross-reactive (can neutralize different types of snake toxins), and that are both broadly cross-reactive and recyclable at the same time. This will open up for entirely new ways of designing biotherapeutics against complex indications, such snakebite envenoming, but also cancer, infectious, and parasitic diseases, where the targets can be elusive due to hyper-mutability. The ERC Starting Grant offers a unique opportunity to consolidate me as an international key scientific researcher in this field of antibody discovery and NTDs. I have already independently led a research group in this area for 2 years, I have in-depth experience with toxin-targeted antibody discovery (my dr.tech dissertation similar to the German “habilitation” will be submitted during fall 2018), and I am already involved in high level policy in the field of snakebite envenoming via my role as a scientific advisor for the World Health Organization.

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The information about "MABSTER" are provided by the European Opendata Portal: CORDIS opendata.

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