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INFISS SIGNED

Targeting infertility associated to defective Insulin/IGF-1 signalling

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 INFISS project word cloud

Explore the words cloud of the INFISS project. It provides you a very rough idea of what is the project "INFISS" about.

reproductive    mitosigage    drugs    igf    mediated    adult    impacts    interaction    ovulation    scientific    stg    diabetes    idea    mental    age    successful    therapeutic    fold    causes    rate    commercial    ovary    later    societies    ovulatory    metabolic    decline    metabolism    directed    contributor    economical    infertility    wellness    evolutionarily    maturation    women    insulin    fourth    motherhood    birth    ascertain    lies    understand    helping    negatively    oocyte    combating    funds    resistance    signalling    erc    iis    modern    basic    suggesting    identification    sterility    suffering    defective    first    blocks    market    energy    pcos    downsides    endocrine    hyperinsulinemia    mitochondrial    conserved    tight    compounds    population    poc    polycystic    suppress    perform    initial    link    tumbling    fertility    disorder    frequently    syndrome    trend    combat    inactivated    world    benefits    bridge    thirds    social    societal    molecular    ageing    patenting    suffer    emanating    society   

Project "INFISS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD PABLO DE OLAVIDE 

Organization address
address: CARRETERA DE UTRERA KM 1
city: SEVILLA
postcode: 41013
website: www.upo.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2018-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD PABLO DE OLAVIDE ES (SEVILLA) coordinator 150˙000.00

Map

 Project objective

Fertility decline is the largest contributor to population ageing in the world today, and infertility negatively impacts on the mental a social wellness of the population affected. One of the causes of birth rate tumbling is the trend of later motherhood in modern societies and the infertility associated to diabetes and polycystic ovary syndrome (PCOS). PCOS is the leading cause for ovulatory infertility, being the most common endocrine and metabolic disorder, affecting women in reproductive age. Women suffering from diabetes frequently suffer from infertility and PCOS, while two-thirds of adult women with PCOS suffer from insulin resistance and hyperinsulinemia. The ERC-StG MitoSigAge funds research directed to understand the process of ageing with a focus on insulin/IGF-1 signalling (IIS) and its interaction with mitochondrial metabolism. PCOS blocks oocyte maturation and ovulation, suggesting a tight link between mitochondrial energy metabolism and oocyte development mediated by IIS. One of the applications emanating from this research lies in the identification of molecular targets to combat diabetes-associated sterility. The objective of the ERC-PoC is four-fold: First, identify evolutionarily conserved molecular targets that, when inactivated, suppress sterility associated to defective IIS. Second, identify existing drugs for the identified targets and ascertain which compounds have the best therapeutic potential. Third, perform the necessary patenting of the compounds for this new application and the initial steps towards the valorisation of the identified products and their commercial potential. Fourth, market studies to evaluate the commercial potential of our technology. These steps will bridge a scientific idea from basic research to therapeutic applications. If successful, it will provide important societal and economical benefits, helping combating the downsides associated to our modern ageing society.

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The information about "INFISS" are provided by the European Opendata Portal: CORDIS opendata.

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