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INFISS SIGNED

Targeting infertility associated to defective Insulin/IGF-1 signalling

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 INFISS project word cloud

Explore the words cloud of the INFISS project. It provides you a very rough idea of what is the project "INFISS" about.

helping    economical    drugs    sterility    later    trend    diabetes    interaction    suffer    molecular    evolutionarily    syndrome    maturation    directed    pcos    decline    societal    fertility    reproductive    identification    endocrine    erc    poc    perform    ovulation    basic    ovulatory    idea    adult    age    resistance    suppress    birth    thirds    suggesting    contributor    causes    combating    ageing    understand    metabolic    funds    benefits    mitochondrial    frequently    scientific    tumbling    tight    defective    metabolism    blocks    mental    ovary    population    therapeutic    hyperinsulinemia    inactivated    compounds    successful    world    suffering    societies    motherhood    downsides    ascertain    market    infertility    wellness    signalling    first    social    oocyte    lies    commercial    iis    combat    negatively    initial    modern    mediated    stg    bridge    emanating    disorder    impacts    link    fourth    conserved    women    patenting    fold    mitosigage    rate    igf    energy    society    polycystic    insulin   

Project "INFISS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD PABLO DE OLAVIDE 

Organization address
address: CARRETERA DE UTRERA KM 1
city: SEVILLA
postcode: 41013
website: www.upo.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2018-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD PABLO DE OLAVIDE ES (SEVILLA) coordinator 150˙000.00

Map

 Project objective

Fertility decline is the largest contributor to population ageing in the world today, and infertility negatively impacts on the mental a social wellness of the population affected. One of the causes of birth rate tumbling is the trend of later motherhood in modern societies and the infertility associated to diabetes and polycystic ovary syndrome (PCOS). PCOS is the leading cause for ovulatory infertility, being the most common endocrine and metabolic disorder, affecting women in reproductive age. Women suffering from diabetes frequently suffer from infertility and PCOS, while two-thirds of adult women with PCOS suffer from insulin resistance and hyperinsulinemia. The ERC-StG MitoSigAge funds research directed to understand the process of ageing with a focus on insulin/IGF-1 signalling (IIS) and its interaction with mitochondrial metabolism. PCOS blocks oocyte maturation and ovulation, suggesting a tight link between mitochondrial energy metabolism and oocyte development mediated by IIS. One of the applications emanating from this research lies in the identification of molecular targets to combat diabetes-associated sterility. The objective of the ERC-PoC is four-fold: First, identify evolutionarily conserved molecular targets that, when inactivated, suppress sterility associated to defective IIS. Second, identify existing drugs for the identified targets and ascertain which compounds have the best therapeutic potential. Third, perform the necessary patenting of the compounds for this new application and the initial steps towards the valorisation of the identified products and their commercial potential. Fourth, market studies to evaluate the commercial potential of our technology. These steps will bridge a scientific idea from basic research to therapeutic applications. If successful, it will provide important societal and economical benefits, helping combating the downsides associated to our modern ageing society.

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The information about "INFISS" are provided by the European Opendata Portal: CORDIS opendata.

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