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Targeting infertility associated to defective Insulin/IGF-1 signalling

Total Cost €


EC-Contrib. €






 INFISS project word cloud

Explore the words cloud of the INFISS project. It provides you a very rough idea of what is the project "INFISS" about.

suppress    drugs    combat    initial    iis    link    syndrome    basic    wellness    funds    population    oocyte    polycystic    mediated    social    evolutionarily    suffering    societies    fertility    world    motherhood    diabetes    impacts    interaction    mitosigage    first    mental    scientific    erc    mitochondrial    energy    directed    economical    lies    endocrine    market    commercial    ovulation    frequently    emanating    contributor    resistance    tumbling    molecular    benefits    thirds    understand    fold    suffer    poc    reproductive    birth    bridge    combating    negatively    ovulatory    helping    societal    metabolic    maturation    signalling    hyperinsulinemia    suggesting    patenting    metabolism    stg    society    ageing    igf    tight    rate    downsides    ovary    women    ascertain    identification    age    modern    insulin    infertility    defective    perform    pcos    therapeutic    fourth    idea    compounds    decline    later    blocks    conserved    inactivated    disorder    sterility    adult    trend    causes    successful   

Project "INFISS" data sheet

The following table provides information about the project.


Organization address
postcode: 41013

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2018-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD PABLO DE OLAVIDE ES (SEVILLA) coordinator 150˙000.00


 Project objective

Fertility decline is the largest contributor to population ageing in the world today, and infertility negatively impacts on the mental a social wellness of the population affected. One of the causes of birth rate tumbling is the trend of later motherhood in modern societies and the infertility associated to diabetes and polycystic ovary syndrome (PCOS). PCOS is the leading cause for ovulatory infertility, being the most common endocrine and metabolic disorder, affecting women in reproductive age. Women suffering from diabetes frequently suffer from infertility and PCOS, while two-thirds of adult women with PCOS suffer from insulin resistance and hyperinsulinemia. The ERC-StG MitoSigAge funds research directed to understand the process of ageing with a focus on insulin/IGF-1 signalling (IIS) and its interaction with mitochondrial metabolism. PCOS blocks oocyte maturation and ovulation, suggesting a tight link between mitochondrial energy metabolism and oocyte development mediated by IIS. One of the applications emanating from this research lies in the identification of molecular targets to combat diabetes-associated sterility. The objective of the ERC-PoC is four-fold: First, identify evolutionarily conserved molecular targets that, when inactivated, suppress sterility associated to defective IIS. Second, identify existing drugs for the identified targets and ascertain which compounds have the best therapeutic potential. Third, perform the necessary patenting of the compounds for this new application and the initial steps towards the valorisation of the identified products and their commercial potential. Fourth, market studies to evaluate the commercial potential of our technology. These steps will bridge a scientific idea from basic research to therapeutic applications. If successful, it will provide important societal and economical benefits, helping combating the downsides associated to our modern ageing society.

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The information about "INFISS" are provided by the European Opendata Portal: CORDIS opendata.

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