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PCELLS SIGNED

Synthetic Cellularity via Protocell Design and Chemical Construction

Total Cost €

EC-Contrib. €

Partnership

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PCELLS project word cloud

Explore the words cloud of the PCELLS project. It provides you a very rough idea of what is the project "PCELLS" about.

proteinosomes phenotypes bioinspired chemistry forms protocells materials behavior compartments architectures chemical induction enzyme interactions micro functioning individual cellularity motile extra pioneer interface experimental endosymbiosis spearheads protocell unprecedented structuring synthetic conceptual modern strategies biology function innovative autonomously fundamentally complexity self construction multidisciplinary endosymbiotic protolife photosynthetic reactor rudimentary basis storage compartmentalization soft functions engineering modular cytomimetic constructs types secretion diverse activated physical technologies hydrogel extended protocellular coordinated science initiate functional paradigm structure collective structural generating cell positioned ensembles matrices communities gene metamorphosis

Project "PCELLS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF BRISTOL Organization address address: BEACON HOUSE QUEENS ROAD city: BRISTOL postcode: BS8 1QU website: www.bristol.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	2˙499˙238 €
EC max contribution	2˙499˙238 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-ADG
Funding Scheme	ERC-ADG
Starting year	2017
Duration (year-month-day)	from 2017-07-01 to 2022-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF BRISTOL UNIVERSITY OF BRISTOL Organization address address: BEACON HOUSE QUEENS ROAD city: BRISTOL postcode: BS8 1QU website: www.bristol.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRISTOL)	coordinator	2˙499˙238.00

Map

Project objective

We propose to undertake an ambitious 5-year multidisciplinary programme that seeks to pioneer and establish a fundamentally new paradigm in protolife research that is based on novel conceptual and experimental advances in the design and construction of rudimentary forms of synthetic cell-like micro-ensembles (protocells). Our approach is positioned at the interface between materials chemistry, soft matter science and synthetic biology, and will address the following aspects of protocell design and construction: (i) functional complexity in protocell phenotypes, (ii) protocell self-structuring and metamorphosis, (iii) multi-compartmentalization and protocell endosymbiosis, and (iv) collective behavior in protocell communities. We will initiate unprecedented increases in the complexity of individual protocells by developing new types of structural architectures with advanced functions including photosynthetic protocells and motile proteinosomes, and develop innovative strategies for the chemical secretion of spatially extended extra-protocellular hydrogel matrices and induction of protocell metamorphosis. We will develop a modular micro-engineering approach to protocell multi-compartmentalization with the aim of generating coordinated enzyme- and gene-activated endosymbiotic interactions, and pioneer the experimental study of collective behaviour in communities of synthetic protocells. Our overall aim is to pioneer a modern approach to synthetic cellularity that advances the chemical and physical basis of protocell structure and function, and spearheads the development of future technologies based on autonomously functioning chemical micro-compartments with applications in bioinspired micro-storage and delivery, micro-reactor technologies, cytomimetic engineering, and the development of integrated constructs for diverse procedures in synthetic biology.

Publications

List of publications.
year	authors and title	journal	last update
2020	Pierangelo Gobbo, Liangfei Tian, B. V. V. S Pavan Kumar, Samuel Turvey, Mattia Cattelan, Avinash J. Patil, Mauro Carraro, Marcella Bonchio, Stephen Mann Catalytic processing in ruthenium-based polyoxometalate coacervate protocells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13759-1	Nature Communications 11/1	2020-03-13
2019	Nicolas Martin, Liangfei Tian, Dan Spencer, AngÃ©lique Coutable-Pennarun, J. L. Ross Anderson, Stephen Mann Photoswitchable Phase Separation and Oligonucleotide Trafficking in DNA Coacervate Microdroplets published pages: 14594-14598, ISSN: 1433-7851, DOI: 10.1002/anie.201909228	Angewandte Chemie International Edition 58/41	2020-03-13
2018	B. V. V. S. Pavan Kumar, Avinash J. Patil, Stephen Mann Enzyme-powered motility in buoyant organoclay/DNA protocells published pages: 1154-1163, ISSN: 1755-4330, DOI: 10.1038/s41557-018-0119-3	Nature Chemistry 10/11	2019-09-02
2018	Jean-Paul Douliez, Nicolas Martin, Thomas Beneyton, Jean-Charles Eloi, Jean-Paul Chapel, Laurence Navailles, Jean-Christophe Baret, Stephen Mann, Laure BÃ©ven Preparation of Swellable Hydrogel-Containing Colloidosomes from Aqueous Two-Phase Pickering Emulsion Droplets published pages: 7780-7784, ISSN: 1433-7851, DOI: 10.1002/anie.201802929	Angewandte Chemie International Edition 57/26	2019-09-02
2018	B. V. V. S. Pavan Kumar, James Fothergill, Joshua Bretherton, Liangfei Tian, Avinash J. Patil, Sean A. Davis, Stephen Mann Chloroplast-containing coacervate micro-droplets as a step towards photosynthetically active membrane-free protocells published pages: 3594-3597, ISSN: 1359-7345, DOI: 10.1039/c8cc01129j	Chemical Communications 54/29	2019-09-02
2019	Alex Joesaar, Shuo Yang, Bas BÃ¶gels, Ardjan van der Linden, Pascal Pieters, B. V. V. S. Pavan Kumar, Neil Dalchau, Andrew Phillips, Stephen Mann, Tom F. A. de Greef DNA-based communication in populations of synthetic protocells published pages: 369-378, ISSN: 1748-3387, DOI: 10.1038/s41565-019-0399-9	Nature Nanotechnology 14/4	2019-09-02
2018	Nicolas Martin, Jean-Paul Douliez, Yan Qiao, Richard Booth, Mei Li, Stephen Mann Antagonistic chemical coupling in self-reconfigurable hostâ€“guest protocells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06087-3	Nature Communications 9/1	2019-09-02
2019	Laura RodrÃguez-Arco, B. V. V. S. Pavan Kumar, Mei Li, Avinash J. Patil, Stephen Mann Modulation of Higher-order Behaviour in Model Protocell Communities by Artificial Phagocytosis published pages: 6333-6337, ISSN: 1433-7851, DOI: 10.1002/anie.201901469	Angewandte Chemie International Edition 58/19	2019-09-02

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