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BLMs 4 TB SIGNED

Beta-lactams for Tuberculosis Treatment

Total Cost €

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EC-Contrib. €

0

Partnership

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 BLMs 4 TB project word cloud

Explore the words cloud of the BLMs 4 TB project. It provides you a very rough idea of what is the project "BLMs 4 TB" about.

treatment    urgently    hope    beta    answer    takes    tb    first    anti    decades    infections    quality    virtually    unpleasant    leads    disease    trial    pharmacodynamics    ram    data    family    pharmacokinetic    xdr    head    dim    microscopy    outcomes    track    lapse    months    questions    deadly    poor    techniques    led    clinical    dr    extensively    linked    pk    microbiology    blms    frequency    discontinued    subset    arose    cephalosporins    prospects    antibiotics    garc    lactams    trials    inform    specificities    optimal    gsk    shorten    undergo    longer    generation    meropenem    administration    adherence    molecular    iia    relapse    severe    resistance    combo    safest    bacterial    modeling    life    pursued    mdr    treat    tuberculosis    barros    outcome    unclear    ineffective    carbapenem    renewed    infectious    agents    killing    patients    last    time    dosage    proteomic    positive    carbapenems    record    cephems    beneficiary    infected    24    transcriptomic    50    treatments    drug    pd    validated    therapy    report    therapies    market    blm    point    glaxosmithkline    iacute    strains    mathematical    resistant    oacute    prevent    worldwide    never    regarded   

Project "BLMs 4 TB" data sheet

The following table provides information about the project.

Coordinator
FUNDACION AGENCIA ARAGONESA PARA LA INVESTIGACION Y EL DESARROLLO 

Organization address
address: PASEO MARIA AGUSTIN 36 EDIFICIO PIGNATELLI PTA 30 PL 2
city: ZARAGOZA
postcode: 50004
website: www.araid.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION AGENCIA ARAGONESA PARA LA INVESTIGACION Y EL DESARROLLO ES (ZARAGOZA) coordinator 170˙121.00

Map

 Project objective

Tuberculosis (TB) is the most deadly infectious disease worldwide. TB therapy takes 6 months with unpleasant side effects that leads to poor adherence and the development of drug resistance. Patients infected with multi (MDR) or extensively (XDR) drug resistant strains must undergo longer treatments (up to 24 months) associated with even severe side effects and only 30-50% positive treatment outcomes. New treatments are urgently needed.

Beta-lactams (BLMs) are the safest antibiotics in the market with a long track record of clinical use to treat bacterial infections. They were, however, traditionally regarded as ineffective for TB therapy to the point that research was virtually discontinued for the last three decades. A renewed interest recently arose after a report of Phase IIa clinical trial validated the potential of meropenem (a carbapenem). This study was led by Dr. Barros, Head TB unit GlaxoSmithKline (GSK) (the beneficiary of this proposal). In addition, Dr. Ramón-García (the applicant) just identified first-generation cephalosporins (cephems), a subset of the BLM family never pursued for TB therapy, as potential anti-TB agents. Promoting BLM development is the best immediate hope for TB patients that currently have very dim life prospects.

Carbapenems and cephems have different anti-bacterial killing properties, pharmacokinetic (PK) and pharmacodynamics (PD) parameters. These specificities affect therapy design for an optimal clinical outcome. Although promising, it is still unclear how BLMs should be included in new combo therapies (i.e. dosage, duration and frequency of administration) to shorten the duration of TB therapy, prevent relapse and treat M(X)DR-TB.

To answer these questions, I will use time-lapse microscopy linked to mathematical PK/PD modeling, transcriptomic and proteomic studies and clinical microbiology techniques to provide high quality molecular and PK/PD pre-clinical data to inform the design of future BLM TB clinical trials.

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The information about "BLMS 4 TB" are provided by the European Opendata Portal: CORDIS opendata.

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