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BLMs 4 TB SIGNED

Beta-lactams for Tuberculosis Treatment

Total Cost €

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EC-Contrib. €

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Partnership

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 BLMs 4 TB project word cloud

Explore the words cloud of the BLMs 4 TB project. It provides you a very rough idea of what is the project "BLMs 4 TB" about.

anti    hope    data    infectious    track    garc    proteomic    pk    led    regarded    infections    modeling    dosage    barros    pharmacodynamics    microscopy    longer    trials    urgently    pursued    mdr    killing    blms    tb    dr    patients    unpleasant    leads    virtually    adherence    answer    discontinued    meropenem    record    blm    cephalosporins    relapse    microbiology    poor    ram    optimal    first    outcomes    resistance    undergo    iacute    gsk    decades    treatments    unclear    xdr    infected    positive    months    linked    dim    subset    carbapenem    takes    oacute    tuberculosis    beneficiary    24    prevent    resistant    head    outcome    trial    combo    techniques    pd    disease    generation    ineffective    drug    quality    therapy    mathematical    inform    strains    extensively    treatment    antibiotics    specificities    point    pharmacokinetic    severe    agents    validated    report    molecular    lapse    glaxosmithkline    renewed    last    deadly    carbapenems    beta    shorten    administration    family    cephems    therapies    clinical    lactams    arose    prospects    market    bacterial    frequency    iia    questions    safest    never    worldwide    transcriptomic    50    treat    life    time   

Project "BLMs 4 TB" data sheet

The following table provides information about the project.

Coordinator		 FUNDACION AGENCIA ARAGONESA PARA LA INVESTIGACION Y EL DESARROLLO 

Organization address
address: PASEO MARIA AGUSTIN 36 EDIFICIO PIGNATELLI PTA 30 PL 2
city: ZARAGOZA
postcode: 50004
website: www.araid.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION AGENCIA ARAGONESA PARA LA INVESTIGACION Y EL DESARROLLO ES (ZARAGOZA) coordinator 170˙121.00

Map

 Project objective

Tuberculosis (TB) is the most deadly infectious disease worldwide. TB therapy takes 6 months with unpleasant side effects that leads to poor adherence and the development of drug resistance. Patients infected with multi (MDR) or extensively (XDR) drug resistant strains must undergo longer treatments (up to 24 months) associated with even severe side effects and only 30-50% positive treatment outcomes. New treatments are urgently needed.

Beta-lactams (BLMs) are the safest antibiotics in the market with a long track record of clinical use to treat bacterial infections. They were, however, traditionally regarded as ineffective for TB therapy to the point that research was virtually discontinued for the last three decades. A renewed interest recently arose after a report of Phase IIa clinical trial validated the potential of meropenem (a carbapenem). This study was led by Dr. Barros, Head TB unit GlaxoSmithKline (GSK) (the beneficiary of this proposal). In addition, Dr. Ramón-García (the applicant) just identified first-generation cephalosporins (cephems), a subset of the BLM family never pursued for TB therapy, as potential anti-TB agents. Promoting BLM development is the best immediate hope for TB patients that currently have very dim life prospects.

Carbapenems and cephems have different anti-bacterial killing properties, pharmacokinetic (PK) and pharmacodynamics (PD) parameters. These specificities affect therapy design for an optimal clinical outcome. Although promising, it is still unclear how BLMs should be included in new combo therapies (i.e. dosage, duration and frequency of administration) to shorten the duration of TB therapy, prevent relapse and treat M(X)DR-TB.

To answer these questions, I will use time-lapse microscopy linked to mathematical PK/PD modeling, transcriptomic and proteomic studies and clinical microbiology techniques to provide high quality molecular and PK/PD pre-clinical data to inform the design of future BLM TB clinical trials.

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The information about "BLMS 4 TB" are provided by the European Opendata Portal: CORDIS opendata.

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