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BLMs 4 TB SIGNED

Beta-lactams for Tuberculosis Treatment

Total Cost €

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EC-Contrib. €

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Partnership

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 BLMs 4 TB project word cloud

Explore the words cloud of the BLMs 4 TB project. It provides you a very rough idea of what is the project "BLMs 4 TB" about.

infected    led    time    months    carbapenems    point    longer    treatments    bacterial    combo    agents    blms    unclear    gsk    lapse    barros    head    techniques    pd    quality    infections    cephalosporins    cephems    glaxosmithkline    50    trial    outcome    decades    mathematical    iia    microscopy    treatment    antibiotics    adherence    first    iacute    drug    disease    family    validated    beneficiary    worldwide    market    ineffective    meropenem    garc    resistance    oacute    undergo    infectious    treat    data    urgently    takes    severe    molecular    renewed    record    xdr    trials    safest    dr    regarded    outcomes    track    24    patients    virtually    strains    proteomic    prospects    therapies    arose    poor    tuberculosis    subset    pursued    relapse    generation    unpleasant    inform    leads    transcriptomic    life    deadly    shorten    therapy    optimal    report    last    hope    specificities    mdr    pk    modeling    lactams    never    microbiology    discontinued    resistant    administration    ram    prevent    linked    pharmacodynamics    blm    tb    anti    carbapenem    questions    clinical    killing    answer    frequency    extensively    positive    dosage    beta    pharmacokinetic    dim   

Project "BLMs 4 TB" data sheet

The following table provides information about the project.

Coordinator		 FUNDACION AGENCIA ARAGONESA PARA LA INVESTIGACION Y EL DESARROLLO 

Organization address
address: PASEO MARIA AGUSTIN 36 EDIFICIO PIGNATELLI PTA 30 PL 2
city: ZARAGOZA
postcode: 50004
website: www.araid.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION AGENCIA ARAGONESA PARA LA INVESTIGACION Y EL DESARROLLO ES (ZARAGOZA) coordinator 170˙121.00

Map

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 Project objective

Tuberculosis (TB) is the most deadly infectious disease worldwide. TB therapy takes 6 months with unpleasant side effects that leads to poor adherence and the development of drug resistance. Patients infected with multi (MDR) or extensively (XDR) drug resistant strains must undergo longer treatments (up to 24 months) associated with even severe side effects and only 30-50% positive treatment outcomes. New treatments are urgently needed.

Beta-lactams (BLMs) are the safest antibiotics in the market with a long track record of clinical use to treat bacterial infections. They were, however, traditionally regarded as ineffective for TB therapy to the point that research was virtually discontinued for the last three decades. A renewed interest recently arose after a report of Phase IIa clinical trial validated the potential of meropenem (a carbapenem). This study was led by Dr. Barros, Head TB unit GlaxoSmithKline (GSK) (the beneficiary of this proposal). In addition, Dr. Ramón-García (the applicant) just identified first-generation cephalosporins (cephems), a subset of the BLM family never pursued for TB therapy, as potential anti-TB agents. Promoting BLM development is the best immediate hope for TB patients that currently have very dim life prospects.

Carbapenems and cephems have different anti-bacterial killing properties, pharmacokinetic (PK) and pharmacodynamics (PD) parameters. These specificities affect therapy design for an optimal clinical outcome. Although promising, it is still unclear how BLMs should be included in new combo therapies (i.e. dosage, duration and frequency of administration) to shorten the duration of TB therapy, prevent relapse and treat M(X)DR-TB.

To answer these questions, I will use time-lapse microscopy linked to mathematical PK/PD modeling, transcriptomic and proteomic studies and clinical microbiology techniques to provide high quality molecular and PK/PD pre-clinical data to inform the design of future BLM TB clinical trials.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BLMS 4 TB" project.

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The information about "BLMS 4 TB" are provided by the European Opendata Portal: CORDIS opendata.

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