Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. m1arna

m1ARNA SIGNED

Transcriptomic m1A - a new key player in the epitranscriptome arena

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 m1ARNA project word cloud

Explore the words cloud of the m1ARNA project. It provides you a very rough idea of what is the project "m1ARNA" about.

preliminary    localization    plays    incognita    operate    alluding    amenable    central    located    identification    outcomes    ones    decorate    dictates    interplay    writers    tuning    whereby    mostly    regulation    data    gene    code    decay    reversible    methyladenosine    putative    resolution    m6a    deposition    context    mrna    concomitantly    expanding    splice    chromatin    animal    machinery    multilayer    n1    circuits    mainly    epigenetics    downstream    translation    chemical    elucidate    map    globally    physiologic    indicate    coding    models    stop    epigenetic    expose    functions    rna    responds    revealed    cell    nucleotide    mapping    codon    effect    m1a    mapped    landmarks    parallel    hundred    manipulations    rnas    upstream    vocabulary    thousands    expression    start    codons    stimuli    mediating    diverse    regulating    pioneered    preferentially    stress    cells    n6    manipulation    erasers    mechanisms    fate    topology    splicing    starting    exhibit    regulate    dependent    environmental    terra    first    genes    dna    modifications    concerted    transcript    mediates    dynamically    single    marks    readers    vicinity    decorates    site    therapeutic    decipher    functional   

Project "m1ARNA" data sheet

The following table provides information about the project.

Coordinator		 MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER 

Organization address
address: TEL HASHOMER SHEBA MEDICAL CENTER
city: RAMAT GAN
postcode: 52621
website: http://www.sheba.co.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Israel [IL]
 Total cost 2˙457˙500 €
 EC max contribution 2˙457˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER IL (RAMAT GAN) coordinator 2˙457˙500.00

Map

 Project objective

Reversible epigenetic modifications regulate gene expression to define cell fate and response to environmental stimuli. Gene expression tuning by DNA and chromatin modifications is well studied, yet the effect of RNA modifications on gene expression is only starting to be revealed. More than a hundred chemical modifications decorate RNAs, mainly non-coding ones, expanding their nucleotide vocabulary and mediating their diverse functions. Several modifications were globally mapped in mRNA. Only two, N6-methyladenosine (m6A) and N1-methyladenosine (m1A) exhibit a distinct topology alluding to a functional role. We pioneered the identification of m6A that is located preferentially in distinct transcript landmarks, mostly around stop codons and mediates transcript localization, splicing, decay and translation. We now identified m1A which decorates thousands of genes mainly in the start codon vicinity, upstream to the first splice site. Our preliminary results indicate that m1A dynamically responds to environmental stimuli and plays a central role in translation regulation. The regulation and functions of m1A are still terra incognita. Our objectives are to identify m1A writers and erasers, elucidate m1A readers and the mechanisms whereby m1A dictates downstream outcomes, particularly translation regulation. We will study m1A functions in response to physiologic stimuli and stress conditions in cells and animal models by manipulation of the m1A deposition machinery. As epigenetic marks operate in a context-dependent concerted way we will map m1A marks concomitantly with m6A to decipher their interplay in regulating gene expression via a putative “epigenetic RNA code”. The data obtained from parallel mapping of m1A and m6A at a single nucleotide and a single transcript resolution, will expose the interplay between these two mRNA modifications in the context of multilayer epigenetics. The study of m1A circuits may identify targets amenable to therapeutic manipulations.

 Publications

year authors and title journal last update
List of publications.
2018 Dan Dominissini, Gideon Rechavi
Epitranscriptome regulation
published pages: , ISSN: 1545-9993, DOI: 10.1038/s41594-018-0140-7 		Nature Structural & Molecular Biology 2020-03-05
2017 Dan Dominissini, Gideon Rechavi
Loud and Clear Epitranscriptomic m1A Signals: Now in Single-Base Resolution
published pages: 825-826, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.11.029 		Molecular Cell 68/5 2019-05-28
2018 Dan Dominissini, Gideon Rechavi
N4-acetylation of Cytidine in mRNA by NAT10 Regulates Stability and Translation
published pages: 1725-1727, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.11.037 		Cell 175/7 2019-05-28

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "M1ARNA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "M1ARNA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

HEIST (2020)

High-temperature Electrochemical Impedance Spectroscopy Transmission electron microscopy on energy materials

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More