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NOVITREP

Novel viral therapy through targeting DNA repair

Total Cost €

EC-Contrib. €

Partnership

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NOVITREP project word cloud

Explore the words cloud of the NOVITREP project. It provides you a very rough idea of what is the project "NOVITREP" about.

diseases repair public therapeutic proteins grant pathogenic damage perform anti microcephaly zoonotic fever erc epidemics global pose inhibitors therapy exists crimean world health disturbs explore income virus newly rna therapies infectious western market therapeutics internationally secure genecadd relationship company treatments born dna hemorrhagic cells cancer power viral suggesting ongoing babies natural individuals ip outbreaks congo drug agency resistance acquired surprise prevent plan business viruses lesions reduce demonstrating investigation potent made human cell revealed tool strategy causing cycle sweden optimize outbreak replication potently cchfv foundation infected causal zikv mechanism ebola discover genetic threatening proof action networks ebov prevented life battle oxidative host zika antiviral constant

Project "NOVITREP" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-PoC
Funding Scheme	ERC-POC
Starting year	2017
Duration (year-month-day)	from 2017-07-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	139˙162.00
2	KAROLINSKA INSTITUTET INNOVATIONS AB KAROLINSKA INSTITUTET INNOVATIONS AB Organization address address: TOMTEBODAVAGEN 23 A city: SOLNA postcode: 171 65 website: www.karolinskainnovations.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SOLNA)	participant	10˙837.00

Map

Project objective

Natural epidemics and outbreaks of emerging infectious diseases are a growing problem internationally. RNA viruses remain under constant attention due to the recent Zika virus (ZIKV) outbreak with potential causal relationship with microcephaly of newly born babies and Ebola virus (EBOV) and Crimean-Congo hemorrhagic fever virus (CCHFV) causing life threatening hemorrhagic fever, demonstrating how zoonotic viruses pose a major global health concern. There is an ongoing need to discover novel therapies to battle these pathogenic viruses given that no specific therapy exists. Developing new antiviral treatments by targeting host cell proteins needed in the viral life cycle is an emerging strategy to improve therapeutic power and reduce acquired drug resistance.

Based on the results from the ERC grant Genetic Networks as a tool for anti-Cancer Drug Development (GENECADD), we have developed potent inhibitors to DNA repair proteins that disturbs repair of oxidative DNA lesions. To our surprise, we observed, in collaboration with Public Health Agency of Sweden, that these inhibitors potently prevent ZIKV, EBOV and CCHFV viral replication in human cells, suggesting that these inhibitors may be used as antiviral therapeutics. Further investigation into the possible mechanism of action revealed that our inhibitors prevented the repair of oxidative damage to RNA.

Here, the overall aim is to (1) further develop and optimize our inhibitors as a novel antiviral target and demonstrate proof of concept, (2) explore and secure IP (3) develop a business plan and (4) perform a market analysis. The overall goal is to develop general antiviral treatments made available to virus-infected individuals through a public foundation in low-income areas or through a company in the Western world.

Publications

List of publications.
year	authors and title	journal	last update
2018	Torkild Visnes, Armando CÃ¡zares-KÃ¶rner, Wenjing Hao, Olov Wallner, Geoffrey Masuyer, Olga Loseva, Oliver Mortusewicz, ElisÃ©e Wiita, Antonio Sarno, Aleksandr Manoilov, Juan Astorga-Wells, Ann-Sofie Jemth, Lang Pan, Kumar Sanjiv, Stella Karsten, Camilla Gokturk, Maurice Grube, Evert J. Homan, Bishoy M. F. Hanna, Cynthia B. J. Paulin, Therese Pham, Azita Rasti, Ulrika Warpman Berglund, Catharina von Nicolai, Carlos Benitez-Buelga, Tobias Koolmeister, Dag Ivanic, Petar Iliev, Martin Scobie, Hans E. Krokan, Pawel Baranczewski, Per Artursson, Mikael Altun, Annika Jenmalm Jensen, Christina KalderÃ©n, Xueqing Ba, Roman A. Zubarev, PÃ¥l Stenmark, Istvan Boldogh, Thomas Helleday Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation published pages: 834-839, ISSN: 0036-8075, DOI: 10.1126/science.aar8048	Science 362/6416	2019-09-04

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The information about "NOVITREP" are provided by the European Opendata Portal: CORDIS opendata.