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BigData Heart SIGNED

Big Data 4 Better Hearts - Sofia ref.: 116074

Total Cost €

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EC-Contrib. €

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Partnership

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 BigData Heart project word cloud

Explore the words cloud of the BigData Heart project. It provides you a very rough idea of what is the project "BigData Heart" about.

patients    productivity    endpoints    death    poor    burden    individual    life    translational    outcomes    components    complicated    clinically    treatments    segmentation    patient    syndrome    treatment    qol    comorbidities    guidelines    mechanisms    underlying    eventual    variations    regard    phenotypes    limited    prognoses    acknowledging    shared    endpoint    world    unpredictable    scientific    earlier    undetectable    atrial    big    slow    organ    constraints    heterogeneous    resolution    fibrillation    platform    candidate    small    optimal    risk    adherence    driving    renders    lowest    disease    markers    form    inter    conventional    expenditures    coronary    validation    heart    acute    bigdata    approval    hospitalisations    scalable    ultimate    data    healthcare    acs    quality    era    definition    drug    expensive    progress    variation    tolerability    mortality    remarkable    therapy    hf    diseases       category    medication    cvd    guide    unselected    unmet    pipelines    damage    trials    phenotypic    unparalleled    chance    morbidities    reflect    aetiology    marketing    af    co    post    capacity    clinical    cardiovascular    hence    insights    despite    groups    proven    molecular    global    oncology    functional   

Project "BigData Heart" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.bigdata-heart.eu/
 Total cost 19˙398˙970 €
 EC max contribution 9˙664˙970 € (50%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2015-07-two-stage
 Funding Scheme IMI2-RIA
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 4˙047˙075.00
2    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 1˙136˙250.00
3    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 929˙375.00
4    SOCIETE EUROPEENNE DE CARDIOLOGIE FR (BIOT SOPHIA ANTIPOLIS) participant 874˙688.00
5    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 391˙845.00
6    FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA ES (VALENCIA) participant 386˙250.00
7    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) participant 386˙250.00
8    THE HYVE BV NL (UTRECHT) participant 326˙250.00
9    INTERNATIONAL CONSORTIUM FOR HEALTHOUTCOMES MEASUREMENT INC. US (CAMBRIDGE MA) participant 319˙375.00
10    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 200˙000.00
11    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) participant 200˙000.00
12    UPPSALA UNIVERSITET SE (UPPSALA) participant 200˙000.00
13    EUROPEAN HEART NETWORK AISBL BE (BRUXELLES) participant 150˙800.00
14    STICHTING MLC FOUNDATION NL (DEN HAAG) participant 116˙812.00
15    BAYER AKTIENGESELLSCHAFT DE (Leverkusen) participant 0.00
16    INSTITUT DE RECHERCHES INTERNATIONALES SERVIER FR (SURESNES) participant 0.00
17    NOVARTIS PHARMA AG CH (BASEL) participant 0.00
18    SOMALOGIC INC US (BOULDER COLORADO) participant 0.00
19    VIFOR (INTERNATIONAL) AG CH (ST GALLEN) participant 0.00

Map

 Project objective

Despite remarkable progress in the management of cardiovascular disease (CVD), major unmet needs remain with regard to mortality, hospitalisations, quality of life (QoL), healthcare expenditures and productivity. Acute coronary syndrome (ACS), atrial fibrillation (AF) and heart failure (HF) are major and growing components of the global CVD burden. Optimal management of these conditions is complicated by their complex aetiology and heterogeneous prognoses. Poor definition at the molecular level and co/multi-morbidities form major challenges for the development and delivery of targeted treatments. This renders response to therapy unpredictable, with large inter-individual variation and, importantly, small or undetectable treatment effects in large trials of unselected patients.

Today’s treatment guidelines still reflect the scientific constraints of an earlier era where clinical markers to guide therapy are limited to conventional risk factors and end-organ damage, and where the main endpoint in clinical trials is patient death. Hence, drug development pipelines from early target validation through to late post-marketing work have proven to be slow, expensive and high-risk: the chance of eventual approval for a CVD drug candidate in Phase I trials is 7%, the lowest of any disease category (shared with oncology) 2. Moreover, tolerability of medication and adherence to treatment show wide variations. There is thus a need for better definition of these diseases, their markers and endpoints (including better segmentation of current heterogeneous patient groups acknowledging underlying mechanisms and comorbidities) and of their outcomes/prognoses (including functional capacity and quality of life [QoL]).

BigData@Heart’s ultimate goal is to develop a Big Data--driven translational research platform of unparalleled scale and phenotypic resolution in order to deliver clinically relevant disease phenotypes, scalable insights from real-world evidence and insights driving

 Deliverables

List of deliverables.
Report on basic model for datasharing and –access, data mapping, curating and analysis within the consortium Documents, reports 2020-04-09 01:08:50
Data management plan Documents, reports 2020-04-09 01:08:49
Minutes of annual meetings Documents, reports 2020-04-09 01:08:50
Open access catalogue detailing the available datasets and associated variables in the consortium Documents, reports 2020-04-09 01:08:49
Periodic reports on advice on legal, ethical and governance issues by the Governance Committee Documents, reports 2020-04-09 01:08:49
First version of the remote monitoring platform, based on RADAR-CNS platform and deployed on Android and iOS, for capturing data for running studies in the consortium Websites, patent fillings, videos etc. 2020-04-09 01:08:49
Annual reports, including an Ethic Report of the external Ethics Advisor Documents, reports 2020-04-09 01:08:49
Detailed project plan, plus tracking tools, to be maintained throughout the life of the project Documents, reports 2020-04-09 01:08:49
Public website Websites, patent fillings, videos etc. 2020-04-09 01:08:49
Minutes of kick-off Documents, reports 2020-04-09 01:08:49
Document detailing distinct project image, including logo and templates for presentations Documents, reports 2020-04-09 01:08:49
Exploitation plan and periodic updates Documents, reports 2020-04-09 01:08:49
Project management plans Documents, reports 2020-04-09 01:08:49
Communication and dissemination plan and periodic updates Documents, reports 2020-04-09 01:08:49
Report of evaluation of enrichment strategies with recommendations Documents, reports 2020-04-09 01:08:49
Collaborative website (intranet) Websites, patent fillings, videos etc. 2020-04-09 01:08:49
Contact database (stakeholders and key project contacts) Documents, reports 2020-04-09 01:08:49

Take a look to the deliverables list in detail:  detailed list of BigData Heart deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Shona Kalkman, Menno Mostert, Christoph Gerlinger, Johannes J. M. van Delden, Ghislaine J. M. W. van Thiel
Responsible data sharing in international health research: a systematic review of principles and norms
published pages: , ISSN: 1472-6939, DOI: 10.1186/s12910-019-0359-9
BMC Medical Ethics 20/1 2020-04-09
2019 Alicia Uijl, Stefan Koudstaal, Kenan Direk, Spiros Denaxas, Rolf H. H. Groenwold, Amitava Banerjee, Arno W. Hoes, Harry Hemingway, Folkert W. Asselbergs
Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records
published pages: , ISSN: 1388-9842, DOI: 10.1002/ejhf.1350
European Journal of Heart Failure 2020-04-09
2018 Sander W van der Laan, Eric L Harshfield, Daiane Hemerich, David Stacey, Angela M Wood, Folkert W Asselbergs
From lipid locus to drug target through human genomics
published pages: , ISSN: 0008-6363, DOI: 10.1093/cvr/cvy120
Cardiovascular Research 2020-04-09
2017 Harry Hemingway, Folkert W Asselbergs, John Danesh, Richard Dobson, Nikolaos Maniadakis, Aldo Maggioni, Ghislaine JM van Thiel, Maureen Cronin, Gunnar Brobert, Panos Vardas, Stefan D Anker, Diederick E Grobbee, Spiros Denaxas, Diederick E Grobbee, Folkert Asselbergs, Arno Hoes, Ghislaine van Thiel, Hans van Delden, René Eijkemans, Rolf Groenwold, Pieter Stolk, Olaf Klungel, Stefan D Anker, Gerd P Hasenfuss, Stephan von Haehling, Panos Vardas, Aldo Maggioni, Gerhard Hindricks, Nikolaos Maniadakis, John Camm, Isabel Bardinet, Christina Dimopoulou, Susanne Løgstrup, Harry Hemingway, Richard Dobson, Aroon Hingorani, Spiros Denaxas, Folkert Asselbergs, JP Casas, Amitava Banerjee, Bernard de Bono, Tom Lumbers, Dan Swerdlow, Riyaz Patel, Claudia Langenberg, John Danesh, Adam Butterworth, Angela Wood, Jason Arora, Josep Redon, FJ Chorro, Juan Carlos Pérez Cortés, J Sanchis, J Nuñez, V Bodi, F Martinez, Daniel Saez-Domingo, Jose L Trillo, Lina Badimon, Tomas Jernberg, Henrik Olsson, Jonas Faxén, Tonje Thorvaldsen, Lars H Lund, Gianluigi Savarese, Stefan James, Bodil Svennblead, Stefan Blankenberg, Tanja Zeller, Renate Schnabel, Evert Ben van Veen, Paulus Kirchhof, Dipak Kotecha, Bodil Svennblead, Stefan James, Jonas Oldgren, Andrea Bayer, Gunnar Brobert, Tomasz Dyszynski, Christoph Gerlinger, Daniel Freitag, John Edward Butler-Ransohoff, Alex Asiimwe, Alexander Michel, Kiliana Suzart-Woischnik, Sebastian Kloss, Frederico Calado, Anders Gabrielsen, Vanessa Blanc, Nicolas Boisseau, Fabrice Couvelard, Willy Gosgnach, Olivier Gryson, Julien Hervouet, Weiwei Li-Bertheau, Benoît Tyl, Jessica Williams, Jessica Ash, Steve Williams, Rachel Ostroff, Alan Williams, Maureen Cronin, Vincent Fabian, Ong Siew Hwa, Avi Leaf, Kees van Bochove, Marinel Cavelaars, Maxim Moinat, Stefan Payralbe
Big data from electronic health records for early and late translational cardiovascular research: challenges and potential
published pages: , ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehx487
European Heart Journal 2020-04-09
2017 Stefan Anker, Folkert Wouter Asselbergs, Gunnar Brobert, Panos Vardas, Diederick E Grobbee, Maureen Cronin
Big Data in Cardiovascular Disease
published pages: 1863-1865, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehx283
European Heart Journal 38/24 2020-04-09

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The information about "BIGDATA HEART" are provided by the European Opendata Portal: CORDIS opendata.

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