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Developing Smart 3D Scaffolds based on Conductive Polymers and Carbon Nanotubes for Cardiac Tissue Engineering

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NanoBeat" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA 

Organization address
address: BARRIO SARRIENA S N
city: LEIOA
postcode: 48940
website: www.ehu.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 257˙191 €
 EC max contribution 257˙191 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA ES (LEIOA) coordinator 257˙191.00
2    REGENTS OF THE UNIVERSITY OF COLORADO US (Boulder CO) partner 0.00

Map

 Project objective

Conductive polymers (CP) appear as promising stimulus-responsing electroactive biomaterial for profileration of cells. CP are versatile materials that can be synthesized in different shapes and morphologies, offering a wide range of application in biosensing, implants, drug delivery and tissue engineering. Carbon Nanotubes (CNTs) have become promising advanced materials and gained increasing importance for applications in nanomedicine, such as diagnosis, disease treatment, imaging, and tissue engineering. CNTs can interact with cells, cross the biological barriers, and modify their functions and biology. More recently, CNTs have become a new tool to specifically interact with the central nervous systems and support tissue repair after brain damage. Take into account of such findings, we hypothesize that CNTs exert functional effects on networks of cardiac myocytes and, in addition, the combination of those two materials will generate an outstanding scaffold for other electroactive cell growth, such as cardiac cells. In my current research, I have developed 3D scaffolds of CNT with a CP skeleton (polypyrrole or PEDOT) and aftewards, the goal of my research and thus the aim of the current proposal is to test such scaffolds for cardiac tissue regeneration. More specific aims are: 1) Adapt already developed smart “scaffold-matrix supports” for heart tissue engineering and test its viability, comprising CNT and conductive polymers. 2) In vitro and in vivo studies of healthy and genetically modified cardiomyocites (CM) of neonatal and adult rat hearts to determine the interactions between cells and the smart scaffolds and demonstrate that such devices promote heart cell growth and change their electrical properties. 3) Test other carbon nanomaterial scaffolds generated in the host group as supports for cardiac tissue engineering.

 Publications

year authors and title journal last update
List of publications.
2018 Nuria Alegret, Antonio Dominguez-Alfaro, David Mecerreyes
3D Scaffolds Based on Conductive Polymers for Biomedical Applications
published pages: 73-89, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01382
Biomacromolecules 20/1 2019-10-15
2018 Nuria Alegret, Antonio Dominguez-Alfaro, Jose M. González-Domínguez, Blanca Arnaiz, Unai Cossío, Susanna Bosi, Ester Vázquez, Pedro Ramos-Cabrer, David Mecerreyes, Maurizio Prato
Three-Dimensional Conductive Scaffolds as Neural Prostheses Based on Carbon Nanotubes and Polypyrrole
published pages: 43904-43914, ISSN: 1944-8244, DOI: 10.1021/acsami.8b16462
ACS Applied Materials & Interfaces 10/50 2019-10-15

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