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Glowsome SIGNED

Encapsulated eukaryotic ribosome assembly

Total Cost €


EC-Contrib. €






 Glowsome project word cloud

Explore the words cloud of the Glowsome project. It provides you a very rough idea of what is the project "Glowsome" about.

structure    nature    interdependent    impression    guarantee    mounted    idea    human    processome    involvement    multifaceted    chambers    linked    discovery    decipher    stepwise    cellular    ribosome    vitro    ribosomal    transcriptional    consuming    thread    ribosomopathies    vital    cell    subunits    thermophile    cascade    plan    small    linear    risk    mechanistic    successful    thermophilum    assays    ordered    encapsulates    cancer    transcriptionally    temporally    earliest    200    90s    rna    assembly    intermediate    functional    sophisticated    form    thermostable    termed    nascent    co    reminiscent    interactions    causing    raises    incorporation    matures    catalyzed    organism    transiently    biology    maturation    enzymes    ribosomes    accurate    particle    protected    protein    unproductive    subunit    diseases    protect    first    spatial    reactions    groundbreaking    establishment    environment    encapsulated    proteins    mold    energy    eukaryotic    recapitulate    interconnected    formed    model    efficient    utilized    scaffold    chaetomium    folds    folding    biogenesis   

Project "Glowsome" data sheet

The following table provides information about the project.


Organization address
postcode: 69117

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The production of fully functional ribosomes is vital for every cell, with failure causing human diseases called ribosomopathies. Eukaryotic ribosome assembly is catalyzed by ~200 assembly factors that guarantee efficient and accurate production of ribosomal subunits along a temporally and spatially ordered pathway. About one third of these factors are utilized in the formation of the earliest biogenesis intermediate, termed 90S pre-ribosome or small subunit processome. Recent insight into the 90S structure from a eukaryotic thermophile, Chaetomium thermophilum, has provided a first spatial impression on this most sophisticated process, which includes co-transcriptional RNA folding and processing, and incorporation of ribosomal proteins. Our key discovery was that the nascent ribosomal RNA, which if linear would form a long thread, is co-transcriptionally mounted into a mold formed by a highly interconnected RNA-protein scaffold on the 90S pre-ribosome. This finding raises a novel concept in RNA biology that nascent RNA folds and matures in a protected environment, which is reminiscent of protein folding that can also occur in folding chambers. I plan to challenge the idea that the 90S particle indeed encapsulates the RNA transiently, in order to protect it from unproductive interactions, allowing stepwise folding and maturation in a cascade of interdependent reactions and the involvement of energy-consuming enzymes. The groundbreaking aim of this proposal is to decipher how these processes occur in an encapsulated environment, using C. thermophilum as a model organism. This high-risk project will depend on the successful establishment of novel assays that recapitulate eukaryotic ribosome assembly in vitro, exploiting the thermostable nature of the 90S pre-ribosome. Mechanistic insight into ribosome biogenesis will lead to a better understanding of how this multifaceted process is linked to other key cellular pathways and development of diseases including cancer.


year authors and title journal last update
List of publications.
2019 Jingdong Cheng, Jochen Baßler, Paulina Fischer, Benjamin Lau, Nikola Kellner, Ruth Kunze, Sabine Griesel, Martina Kallas, Otto Berninghausen, Daniela Strauss, Roland Beckmann, Ed Hurt
Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration
published pages: 1256-1269.e7, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.06.032
Molecular Cell 75/6 2020-04-24

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The information about "GLOWSOME" are provided by the European Opendata Portal: CORDIS opendata.

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