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Glowsome SIGNED

Encapsulated eukaryotic ribosome assembly

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Glowsome project word cloud

Explore the words cloud of the Glowsome project. It provides you a very rough idea of what is the project "Glowsome" about.

small    catalyzed    nascent    multifaceted    folding    reactions    utilized    energy    enzymes    encapsulates    raises    impression    reminiscent    thermostable    linked    chaetomium    efficient    processome    earliest    subunit    ribosomal    transiently    idea    eukaryotic    assays    guarantee    model    cancer    organism    unproductive    co    structure    recapitulate    incorporation    stepwise    sophisticated    protein    encapsulated    thermophile    protected    successful    protect    assembly    functional    decipher    ribosome    spatial    intermediate    environment    thread    nature    transcriptionally    interdependent    groundbreaking    form    mechanistic    cell    90s    involvement    cellular    ribosomopathies    thermophilum    rna    scaffold    causing    accurate    formed    first    termed    linear    transcriptional    biology    biogenesis    subunits    vitro    interconnected    establishment    vital    mold    human    matures    diseases    risk    ordered    proteins    cascade    interactions    temporally    plan    particle    consuming    chambers    folds    mounted    discovery    ribosomes    maturation    200   

Project "Glowsome" data sheet

The following table provides information about the project.

Coordinator
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG 

Organization address
address: SEMINARSTRASSE 2
city: HEIDELBERG
postcode: 69117
website: www.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) coordinator 2˙000˙000.00

Map

 Project objective

The production of fully functional ribosomes is vital for every cell, with failure causing human diseases called ribosomopathies. Eukaryotic ribosome assembly is catalyzed by ~200 assembly factors that guarantee efficient and accurate production of ribosomal subunits along a temporally and spatially ordered pathway. About one third of these factors are utilized in the formation of the earliest biogenesis intermediate, termed 90S pre-ribosome or small subunit processome. Recent insight into the 90S structure from a eukaryotic thermophile, Chaetomium thermophilum, has provided a first spatial impression on this most sophisticated process, which includes co-transcriptional RNA folding and processing, and incorporation of ribosomal proteins. Our key discovery was that the nascent ribosomal RNA, which if linear would form a long thread, is co-transcriptionally mounted into a mold formed by a highly interconnected RNA-protein scaffold on the 90S pre-ribosome. This finding raises a novel concept in RNA biology that nascent RNA folds and matures in a protected environment, which is reminiscent of protein folding that can also occur in folding chambers. I plan to challenge the idea that the 90S particle indeed encapsulates the RNA transiently, in order to protect it from unproductive interactions, allowing stepwise folding and maturation in a cascade of interdependent reactions and the involvement of energy-consuming enzymes. The groundbreaking aim of this proposal is to decipher how these processes occur in an encapsulated environment, using C. thermophilum as a model organism. This high-risk project will depend on the successful establishment of novel assays that recapitulate eukaryotic ribosome assembly in vitro, exploiting the thermostable nature of the 90S pre-ribosome. Mechanistic insight into ribosome biogenesis will lead to a better understanding of how this multifaceted process is linked to other key cellular pathways and development of diseases including cancer.

 Publications

year authors and title journal last update
List of publications.
2019 Jingdong Cheng, Jochen Baßler, Paulina Fischer, Benjamin Lau, Nikola Kellner, Ruth Kunze, Sabine Griesel, Martina Kallas, Otto Berninghausen, Daniela Strauss, Roland Beckmann, Ed Hurt
Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration
published pages: 1256-1269.e7, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.06.032
Molecular Cell 75/6 2020-04-24

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