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SynCrop SIGNED

Synthetic Circuits for Robust Orthogonal Production

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SynCrop" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET HAMBURG 

Organization address
address: MITTELWEG 177
city: HAMBURG
postcode: 20148
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 3˙971˙347 €
 EC max contribution 3˙971˙347 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2017
 Funding Scheme MSCA-ITN-ETN
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET HAMBURG DE (HAMBURG) coordinator 498˙432.00
2    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) participant 546˙575.00
3    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) participant 510˙748.00
4    BIOSYNTIA APS DK (HORSHOLM) participant 290˙081.00
5    CHR. HANSEN A/S DK (HOERSHOLM) participant 290˙081.00
6    THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN UK (ABERDEEN) participant 273˙287.00
7    UNIVERSITY OF YORK UK (YORK NORTH YORKSHIRE) participant 273˙287.00
8    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 265˙226.00
9    CHALMERS TEKNISKA HOEGSKOLA AB SE (GOETEBORG) participant 263˙659.00
10    DSM FOOD SPECIALTIES BV NL (DELFT) participant 255˙374.00
11    STICHTING VU NL (AMSTERDAM) participant 255˙374.00
12    TECHNISCHE UNIVERSITAT BERLIN DE (BERLIN) participant 249˙216.00
13    BIOFACTION KG AT (WIEN) partner 0.00
14    INSILICO BIOTECHNOLOGY AG DE (STUTTGART) partner 0.00
15    LANTHIOPEP BV NL (GRONINGEN) partner 0.00
16    UNIVERSITY OF BRISTOL UK (BRISTOL) partner 0.00

Map

 Project objective

The repertoire of industrially produced fine chemicals in various biological systems will rapidly expand using the tools from the emerging field of synthetic biology. However, the high-level production of non-natural products or de novo activities through synthetic circuits compromises the integrity of host organisms, which significantly impacts or even prevents the development of an industrial pipeline. Our ability to exploit the potential of synthetic biology for industrial production is constrained by our understanding of the integrated cell response when introducing a new synthetic circuit into the homeostatic network of the cell. SynCrop’s main goal is to establish a European Training Network that merges the fragmented scientific expertise in theoretical, experimental and application-driven quantitative biology to educate the next generation of researchers to construct modular and tunable synthetic circuits and foster the development of novel production platforms for food additives (e.g. vitamins, carotenoids and exopolysaccharides). Researchers with inter-disciplinary skills in both experimental and computational biology are needed to solve complex application-driven problems. SynCrop brings together ten academic partners from quantitative biology, cell engineering, microbial physiology and mathematical modelling fields and six industrial partners, including key experts in metabolic engineering and industrial biotechnology. The consortium will provide 15 early-stage researchers with cutting-edge multi-disciplinary research training, through tailored research projects, rigorous exchange of expertise among researchers and partners, and participation in specialised courses, workshops and conferences augmented by extensive training in complementary skills. SynCrop will generate a strong cohort of highly-employable scientists with unique inter-disciplinary and intersectoral skills to address complex questions and develop innovative biotechnological processes.

 Deliverables

List of deliverables.
Data set of single-cell of stress-responsive transcription factors Documents, reports 2020-04-16 15:13:55
Panel of biosensors directed to specific locations in the cell (organelles in S. cerevisiae; cytosol or membrane of E. coli) Other 2020-04-16 15:12:47
Mid-term special session at an international conference CF1 Other 2020-04-16 15:13:34
Researcher Declarations on Conformity Other 2020-04-16 15:13:39
Transferable skills courses Other 2020-04-16 15:13:29
Map of charged tRNAome in S. cerevisiae and in E. coli when expressing different production circuits Documents, reports 2020-04-16 15:13:13
Parameterised kinetic model of E. coli glycolysis/gluconeogenesis and pentose phosphate pathway Documents, reports 2020-04-16 15:13:08
Data set of single-cell measurements of global physiological variables Documents, reports 2020-04-16 15:13:03
Chromosomally located fluorescently-tagged expression strains Documents, reports 2020-04-16 15:12:57
Theory for robust circuit design with optimal specific fluxes Documents, reports 2020-04-16 15:13:50
Project website Documents, reports 2020-04-16 15:13:45
Map of the position of translating ribosomes in S. cerevisiae and in E. coli when expressing different production circuits Documents, reports 2020-04-16 15:13:18
Scientific courses Other 2020-04-16 15:13:23
Systems for monitoring and quantifying crowding stress Other 2020-04-16 15:12:52
Overall Recruitment Other 2020-03-24 09:23:02
Supervisory Board constitution Other 2020-03-24 09:23:02

Take a look to the deliverables list in detail:  detailed list of SynCrop deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Sofia Markakiou, Paula Gaspar, Eric Johansen, Ahmad A Zeidan, Ana Rute Neves
Harnessing the metabolic potential of Streptococcus thermophilus for new biotechnological applications
published pages: 142-152, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2019.12.019
Current Opinion in Biotechnology 61 2020-03-24

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The information about "SYNCROP" are provided by the European Opendata Portal: CORDIS opendata.

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