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SynCrop SIGNED

Synthetic Circuits for Robust Orthogonal Production

Total Cost €

EC-Contrib. €

Partnership

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SynCrop project word cloud

Explore the words cloud of the SynCrop project. It provides you a very rough idea of what is the project "SynCrop" about.

scientific pipeline questions integrity biotechnology brings tunable fragmented modular extensive expertise platforms construct complementary fine merges generation physiology employable edge microbial cutting quantitative scientists courses compromises stage industrial rigorous natural workshops exopolysaccharides theoretical industrially participation network circuit skills 15 constrained biological conferences organisms carotenoids mathematical experts intersectoral vitamins training tools disciplinary six specialised homeostatic synthetic biotechnological engineering expand food experimental generate circuits ten educate chemicals prevents biology impacts cell host repertoire additives computational cohort augmented syncrop innovative inter de academic introducing exchange metabolic novo significantly

Project "SynCrop" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAET HAMBURG Organization address address: MITTELWEG 177 city: HAMBURG postcode: 20148 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	3˙971˙347 €
EC max contribution	3˙971˙347 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2017
Funding Scheme	MSCA-ITN-ETN
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAET HAMBURG UNIVERSITAET HAMBURG Organization address address: MITTELWEG 177 city: HAMBURG postcode: 20148 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HAMBURG)	coordinator	498˙432.00
2	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	546˙575.00
3	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	510˙748.00
4	BIOSYNTIA APS BIOSYNTIA APS Organization address address: KOGLE ALLE 6 city: HORSHOLM postcode: 2970 website: www.biosyntia.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HORSHOLM)	participant	290˙081.00
5	CHR. HANSEN A/S CHR. HANSEN A/S Organization address address: BOEGE ALLE 10-12 city: HOERSHOLM postcode: 2970 website: www.chr-hansen.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HOERSHOLM)	participant	290˙081.00
6	THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN Organization address address: KING'S COLLEGE REGENT WALK city: ABERDEEN postcode: AB24 3FX website: http://www.abdn.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (ABERDEEN)	participant	273˙287.00
7	UNIVERSITY OF YORK UNIVERSITY OF YORK Organization address address: HESLINGTON city: YORK NORTH YORKSHIRE postcode: YO10 5DD website: http://www.york.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (YORK NORTH YORKSHIRE)	participant	273˙287.00
8	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	participant	265˙226.00
9	CHALMERS TEKNISKA HOEGSKOLA AB CHALMERS TEKNISKA HOEGSKOLA AB Organization address address: - city: GOETEBORG postcode: 41296 website: www.chalmers.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	participant	263˙659.00
10	DSM FOOD SPECIALTIES BV DSM FOOD SPECIALTIES BV Organization address address: ALEXANDER FLEMINGLAAN 1 city: DELFT postcode: 2613 AX website: www.dsmfoodspecialties.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DELFT)	participant	255˙374.00
11	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	255˙374.00
12	TECHNISCHE UNIVERSITAT BERLIN TECHNISCHE UNIVERSITAT BERLIN Organization address address: STRASSE DES 17 JUNI 135 city: BERLIN postcode: 10623 website: www.tu-berlin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	249˙216.00
13	BIOFACTION KG BIOFACTION KG Organization address address: KUNDMANNGASSE 39/12 city: WIEN postcode: 1030 website: www.biofaction.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	partner	0.00
14	INSILICO BIOTECHNOLOGY AG INSILICO BIOTECHNOLOGY AG Organization address address: MEITNERSTRASSE 9 city: STUTTGART postcode: 70563 website: www.insilico-biotechnology.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (STUTTGART)	partner	0.00
15	LANTHIOPEP BV LANTHIOPEP BV Organization address address: ROZENBURGLAAN 13B city: GRONINGEN postcode: 9727 DL website: www.lanthiopharma.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	partner	0.00
16	UNIVERSITY OF BRISTOL UNIVERSITY OF BRISTOL Organization address address: BEACON HOUSE QUEENS ROAD city: BRISTOL postcode: BS8 1QU website: www.bristol.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRISTOL)	partner	0.00

Map

Project objective

The repertoire of industrially produced fine chemicals in various biological systems will rapidly expand using the tools from the emerging field of synthetic biology. However, the high-level production of non-natural products or de novo activities through synthetic circuits compromises the integrity of host organisms, which significantly impacts or even prevents the development of an industrial pipeline. Our ability to exploit the potential of synthetic biology for industrial production is constrained by our understanding of the integrated cell response when introducing a new synthetic circuit into the homeostatic network of the cell. SynCrop’s main goal is to establish a European Training Network that merges the fragmented scientific expertise in theoretical, experimental and application-driven quantitative biology to educate the next generation of researchers to construct modular and tunable synthetic circuits and foster the development of novel production platforms for food additives (e.g. vitamins, carotenoids and exopolysaccharides). Researchers with inter-disciplinary skills in both experimental and computational biology are needed to solve complex application-driven problems. SynCrop brings together ten academic partners from quantitative biology, cell engineering, microbial physiology and mathematical modelling fields and six industrial partners, including key experts in metabolic engineering and industrial biotechnology. The consortium will provide 15 early-stage researchers with cutting-edge multi-disciplinary research training, through tailored research projects, rigorous exchange of expertise among researchers and partners, and participation in specialised courses, workshops and conferences augmented by extensive training in complementary skills. SynCrop will generate a strong cohort of highly-employable scientists with unique inter-disciplinary and intersectoral skills to address complex questions and develop innovative biotechnological processes.

Deliverables

List of deliverables.
Data set of single-cell of stress-responsive transcription factors	Documents, reports	2020-04-16 15:13:55
Panel of biosensors directed to specific locations in the cell (organelles in S. cerevisiae; cytosol or membrane of E. coli)	Other	2020-04-16 15:12:47
Mid-term special session at an international conference CF1	Other	2020-04-16 15:13:34
Researcher Declarations on Conformity	Other	2020-04-16 15:13:39
Transferable skills courses	Other	2020-04-16 15:13:29
Map of charged tRNAome in S. cerevisiae and in E. coli when expressing different production circuits	Documents, reports	2020-04-16 15:13:13
Parameterised kinetic model of E. coli glycolysis/gluconeogenesis and pentose phosphate pathway	Documents, reports	2020-04-16 15:13:08
Data set of single-cell measurements of global physiological variables	Documents, reports	2020-04-16 15:13:03
Chromosomally located fluorescently-tagged expression strains	Documents, reports	2020-04-16 15:12:57
Theory for robust circuit design with optimal specific fluxes	Documents, reports	2020-04-16 15:13:50
Project website	Documents, reports	2020-04-16 15:13:45
Map of the position of translating ribosomes in S. cerevisiae and in E. coli when expressing different production circuits	Documents, reports	2020-04-16 15:13:18
Scientific courses	Other	2020-04-16 15:13:23
Systems for monitoring and quantifying crowding stress	Other	2020-04-16 15:12:52
Overall Recruitment	Other	2020-03-24 09:23:02
Supervisory Board constitution	Other	2020-03-24 09:23:02

Take a look to the deliverables list in detail: detailed list of SynCrop deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Sofia Markakiou, Paula Gaspar, Eric Johansen, Ahmad A Zeidan, Ana Rute Neves Harnessing the metabolic potential of Streptococcus thermophilus for new biotechnological applications published pages: 142-152, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2019.12.019	Current Opinion in Biotechnology 61	2020-03-24

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The information about "SYNCROP" are provided by the European Opendata Portal: CORDIS opendata.