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GlymphEye SIGNED

The Ocular Glymphatic System

Total Cost €


EC-Contrib. €






 GlymphEye project word cloud

Explore the words cloud of the GlymphEye project. It provides you a very rough idea of what is the project "GlymphEye" about.

drive    subjacent    mechanistically    amyloid    human    decrease    optic    waste    share    therapeutically    uncleared    visual    glaucoma    adult    fundamentally    either    accumulation    cells    ganglion    brain    mechanism    retinal    intractable    lymphatic    previously    cellular    modified    allied    ocular    animals    suppression    regulated    wake    wastes    protein    literature    link    wp1    nerve    disorders    imaging    normal    critically    fluid    export    mri    wp3    pressure    instead    age    65    secondary    cycle    dysregulation    resistant    preparation    wp4    vessels    sleep    team    macular    pigment    live    toxicity    vivo    thought    dependent    glymphatic    intraocular    existence    substrate    metabolic    epithelium    mechanisms    causes    unrelated    toxic    neurodegenerative    contributes    biology    magnetic    shown    degeneration    hypothesis    clears    resonance    wp5    ex    transport    caused    treatment    removed    eye    wp2    causal    diseases    beta   

Project "GlymphEye" data sheet

The following table provides information about the project.


Organization address
address: NORREGADE 10
postcode: 1165

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 2˙176˙250 €
 EC max contribution 2˙176˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 2˙176˙250.00


 Project objective

The glymphatic system is a highly organized brain-wide mechanism by which fluid wastes are removed from the brain that was recently described by my team. The glymphatic system clears 65% of amyloid-beta from the normal adult brain. A rapidly evolving literature has shown that the major neurodegenerative diseases of the eye, macular degeneration and glaucoma, may also result from the toxicity of uncleared protein wastes, including amyloid-beta. Yet the eye, like the brain, has no traditional lymphatic vessels. In this application, I propose that two of the most significant causes of human visual loss, macular degeneration and glaucoma – previously thought of as both intractable and unrelated – are instead mechanistically allied disorders that not only share a common causal pathway, but may both be therapeutically modified by targeting dysregulation of the glymphatic pathway. As such, this proposal seeks to link the biology of a fundamentally new pathway for both metabolic substrate and waste transport in the adult brain, to diseases of the eye that have long been resistant to either understanding or treatment. The objectives: WP1: Define the cellular mechanisms that drive ocular glymphatic transport of Amyloid-beta using an ex vivo preparation of the optic nerve. WP2: Use magnetic resonance imaging (MRI) to establish the existence of ocular glymphatic transport in live animals. WP3: Determine whether the ocular glymphatic system, like the brain lymphatic system, is critically regulated by the sleep-wake cycle. WP4: Test the hypothesis that age-dependent macular degeneration is caused by a suppression of ocular glymphatic transport, with secondary accumulation of toxic protein products in and subjacent to the retinal pigment epithelium? WP5: Define the impact of increased intraocular pressure on glymphatic export of amyloid-beta, and test the hypothesis that the decrease in ocular glymphatic transport contributes to degeneration of retinal ganglion cells in glaucoma.

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The information about "GLYMPHEYE" are provided by the European Opendata Portal: CORDIS opendata.

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