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GlymphEye SIGNED

The Ocular Glymphatic System

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GlymphEye project word cloud

Explore the words cloud of the GlymphEye project. It provides you a very rough idea of what is the project "GlymphEye" about.

transport    human    eye    suppression    removed    live    biology    pigment    wp1    normal    optic    either    literature    modified    vessels    pressure    shown    glaucoma    cellular    wp2    share    intraocular    degeneration    animals    retinal    nerve    age    mechanism    intractable    amyloid    imaging    fluid    beta    contributes    accumulation    therapeutically    65    vivo    decrease    regulated    causes    ganglion    ocular    cells    wastes    lymphatic    critically    mechanistically    mri    hypothesis    toxicity    substrate    neurodegenerative    diseases    sleep    causal    preparation    wp5    adult    protein    ex    team    dependent    wp4    wp3    glymphatic    cycle    subjacent    metabolic    dysregulation    clears    visual    link    uncleared    waste    instead    allied    drive    macular    caused    resonance    wake    existence    resistant    mechanisms    export    previously    treatment    brain    toxic    fundamentally    magnetic    secondary    disorders    epithelium    thought    unrelated   

Project "GlymphEye" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 2˙176˙250 €
 EC max contribution 2˙176˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 2˙176˙250.00

Map

 Project objective

The glymphatic system is a highly organized brain-wide mechanism by which fluid wastes are removed from the brain that was recently described by my team. The glymphatic system clears 65% of amyloid-beta from the normal adult brain. A rapidly evolving literature has shown that the major neurodegenerative diseases of the eye, macular degeneration and glaucoma, may also result from the toxicity of uncleared protein wastes, including amyloid-beta. Yet the eye, like the brain, has no traditional lymphatic vessels. In this application, I propose that two of the most significant causes of human visual loss, macular degeneration and glaucoma – previously thought of as both intractable and unrelated – are instead mechanistically allied disorders that not only share a common causal pathway, but may both be therapeutically modified by targeting dysregulation of the glymphatic pathway. As such, this proposal seeks to link the biology of a fundamentally new pathway for both metabolic substrate and waste transport in the adult brain, to diseases of the eye that have long been resistant to either understanding or treatment. The objectives: WP1: Define the cellular mechanisms that drive ocular glymphatic transport of Amyloid-beta using an ex vivo preparation of the optic nerve. WP2: Use magnetic resonance imaging (MRI) to establish the existence of ocular glymphatic transport in live animals. WP3: Determine whether the ocular glymphatic system, like the brain lymphatic system, is critically regulated by the sleep-wake cycle. WP4: Test the hypothesis that age-dependent macular degeneration is caused by a suppression of ocular glymphatic transport, with secondary accumulation of toxic protein products in and subjacent to the retinal pigment epithelium? WP5: Define the impact of increased intraocular pressure on glymphatic export of amyloid-beta, and test the hypothesis that the decrease in ocular glymphatic transport contributes to degeneration of retinal ganglion cells in glaucoma.

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The information about "GLYMPHEYE" are provided by the European Opendata Portal: CORDIS opendata.

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