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GlymphEye SIGNED

The Ocular Glymphatic System

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GlymphEye project word cloud

Explore the words cloud of the GlymphEye project. It provides you a very rough idea of what is the project "GlymphEye" about.

cellular    lymphatic    waste    pigment    hypothesis    allied    fundamentally    degeneration    contributes    adult    65    shown    toxicity    biology    accumulation    ganglion    nerve    magnetic    metabolic    brain    preparation    clears    secondary    human    mechanisms    age    existence    unrelated    causes    thought    wp1    wp3    previously    imaging    cells    regulated    caused    live    wastes    eye    literature    link    amyloid    modified    wp4    intraocular    dysregulation    normal    wp2    decrease    macular    sleep    ocular    either    visual    resistant    protein    mechanistically    share    uncleared    mri    suppression    wp5    removed    diseases    animals    optic    ex    neurodegenerative    vivo    drive    export    retinal    dependent    team    causal    wake    disorders    pressure    beta    therapeutically    toxic    instead    resonance    epithelium    glymphatic    intractable    vessels    glaucoma    fluid    cycle    critically    substrate    mechanism    subjacent    treatment    transport   

Project "GlymphEye" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 2˙176˙250 €
 EC max contribution 2˙176˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 2˙176˙250.00

Map

 Project objective

The glymphatic system is a highly organized brain-wide mechanism by which fluid wastes are removed from the brain that was recently described by my team. The glymphatic system clears 65% of amyloid-beta from the normal adult brain. A rapidly evolving literature has shown that the major neurodegenerative diseases of the eye, macular degeneration and glaucoma, may also result from the toxicity of uncleared protein wastes, including amyloid-beta. Yet the eye, like the brain, has no traditional lymphatic vessels. In this application, I propose that two of the most significant causes of human visual loss, macular degeneration and glaucoma – previously thought of as both intractable and unrelated – are instead mechanistically allied disorders that not only share a common causal pathway, but may both be therapeutically modified by targeting dysregulation of the glymphatic pathway. As such, this proposal seeks to link the biology of a fundamentally new pathway for both metabolic substrate and waste transport in the adult brain, to diseases of the eye that have long been resistant to either understanding or treatment. The objectives: WP1: Define the cellular mechanisms that drive ocular glymphatic transport of Amyloid-beta using an ex vivo preparation of the optic nerve. WP2: Use magnetic resonance imaging (MRI) to establish the existence of ocular glymphatic transport in live animals. WP3: Determine whether the ocular glymphatic system, like the brain lymphatic system, is critically regulated by the sleep-wake cycle. WP4: Test the hypothesis that age-dependent macular degeneration is caused by a suppression of ocular glymphatic transport, with secondary accumulation of toxic protein products in and subjacent to the retinal pigment epithelium? WP5: Define the impact of increased intraocular pressure on glymphatic export of amyloid-beta, and test the hypothesis that the decrease in ocular glymphatic transport contributes to degeneration of retinal ganglion cells in glaucoma.

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The information about "GLYMPHEYE" are provided by the European Opendata Portal: CORDIS opendata.

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