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GlymphEye SIGNED

The Ocular Glymphatic System

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GlymphEye project word cloud

Explore the words cloud of the GlymphEye project. It provides you a very rough idea of what is the project "GlymphEye" about.

ex    allied    disorders    resonance    vessels    visual    degeneration    brain    critically    mechanisms    vivo    wake    diseases    epithelium    therapeutically    uncleared    animals    contributes    resistant    modified    fundamentally    unrelated    age    subjacent    toxicity    normal    export    pressure    link    ocular    macular    suppression    instead    metabolic    hypothesis    beta    wp1    imaging    dependent    treatment    wp5    glaucoma    retinal    pigment    wp4    either    lymphatic    intractable    previously    eye    intraocular    protein    biology    preparation    dysregulation    secondary    mri    sleep    shown    causal    ganglion    accumulation    mechanistically    drive    65    decrease    magnetic    human    mechanism    fluid    cellular    cells    toxic    existence    removed    neurodegenerative    waste    team    caused    wastes    adult    wp3    causes    amyloid    cycle    nerve    regulated    wp2    clears    glymphatic    transport    literature    substrate    thought    optic    share    live   

Project "GlymphEye" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 2˙176˙250 €
 EC max contribution 2˙176˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 2˙176˙250.00

Map

 Project objective

The glymphatic system is a highly organized brain-wide mechanism by which fluid wastes are removed from the brain that was recently described by my team. The glymphatic system clears 65% of amyloid-beta from the normal adult brain. A rapidly evolving literature has shown that the major neurodegenerative diseases of the eye, macular degeneration and glaucoma, may also result from the toxicity of uncleared protein wastes, including amyloid-beta. Yet the eye, like the brain, has no traditional lymphatic vessels. In this application, I propose that two of the most significant causes of human visual loss, macular degeneration and glaucoma – previously thought of as both intractable and unrelated – are instead mechanistically allied disorders that not only share a common causal pathway, but may both be therapeutically modified by targeting dysregulation of the glymphatic pathway. As such, this proposal seeks to link the biology of a fundamentally new pathway for both metabolic substrate and waste transport in the adult brain, to diseases of the eye that have long been resistant to either understanding or treatment. The objectives: WP1: Define the cellular mechanisms that drive ocular glymphatic transport of Amyloid-beta using an ex vivo preparation of the optic nerve. WP2: Use magnetic resonance imaging (MRI) to establish the existence of ocular glymphatic transport in live animals. WP3: Determine whether the ocular glymphatic system, like the brain lymphatic system, is critically regulated by the sleep-wake cycle. WP4: Test the hypothesis that age-dependent macular degeneration is caused by a suppression of ocular glymphatic transport, with secondary accumulation of toxic protein products in and subjacent to the retinal pigment epithelium? WP5: Define the impact of increased intraocular pressure on glymphatic export of amyloid-beta, and test the hypothesis that the decrease in ocular glymphatic transport contributes to degeneration of retinal ganglion cells in glaucoma.

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The information about "GLYMPHEYE" are provided by the European Opendata Portal: CORDIS opendata.

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