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PRO_PHAGE SIGNED

Impact and interaction of prophage elements in bacterial host strains of biotechnological relevance

Total Cost €

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EC-Contrib. €

0

Partnership

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 PRO_PHAGE project word cloud

Explore the words cloud of the PRO_PHAGE project. It provides you a very rough idea of what is the project "PRO_PHAGE" about.

added    phenotyping    prey    insights    immense    improvement    purpose    earth    temperate    silencing    association    sequencing    integrate    compounds    applicable    sustainable    subsequent    engineering    flexible    close    significantly    bioeconomy    analysed    resolution    beneficial    combining    spontaneous    risks    xenogeneic    bacteria    activation    bacteriophages    gene    illustrated    chassis    generate    hosts    host    cell    throughput    genome    fluorescence    inhabitants    abundant    foreign    population    single    dynamics    product    virus    phages    genomes    diverse    explorative    workflow    microbial    prophages    triggers    sorting    microbes    expression    benchmarked    transition    evolution    pursuing    mutually    viruses    bioinformatic    metabolic    proteins    will    strains    reveal    shaped    unprecedented    generation    pro    activated    regulatory    bacterial    genetic    integration    unexplored    decipher    dna    fitness    ht    genomic    encoded    interaction    traits    phage    molecular    resource    ngs    industrial    almost    broadly   

Project "PRO_PHAGE" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSZENTRUM JULICH GMBH 

Organization address
address: WILHELM JOHNEN STRASSE
city: JULICH
postcode: 52428
website: www.fz-juelich.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙482˙672 €
 EC max contribution 1˙482˙672 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSZENTRUM JULICH GMBH DE (JULICH) coordinator 1˙482˙672.00

Map

 Project objective

Phages, viruses that prey on bacteria, are the most abundant and diverse inhabitants of the Earth. Temperate bacteriophages are able to integrate into the host genome and maintain as prophages a long-term association with their host. Illustrated by the development of mutually beneficial traits, this close interaction between host and virus has significantly shaped bacterial evolution. However, the immense genetic resources of phage genomes still remain almost unexplored. For the transition to a sustainable bioeconomy, we strongly depend on microbes as hosts for the production of value-added compounds. PRO_PHAGE will exploit recent advances in next-generation sequencing (NGS), single-cell analysis, and high-throughput (HT) phenotyping to evaluate the impact of phage elements on host fitness and to use this knowledge for the improvement of future metabolic engineering approaches. By combining an explorative approach with subsequent molecular analysis of selected targets, PRO_PHAGE will deliver novel insights into this genetic resource and will reveal the risks and potential for metabolic engineering by pursuing four major objectives. 1) Based on a comprehensive bioinformatic analysis, the impact of phage elements will be studied by HT phenotyping of selected strains. 2) The regulatory interaction of phage and host will be analysed by focusing on host-encoded xenogeneic silencing proteins and their role in the integration of foreign DNA. 3) The spontaneous activation of phage elements will be studied at the genomic scale to decipher molecular triggers and their impact on host gene expression. For this purpose, a novel workflow combining fluorescence-activated cell sorting and NGS will be developed, which will be broadly applicable for studying microbial population dynamics at unprecedented resolution. 4) Finally, the insights obtained will be benchmarked for metabolic engineering approaches in order to generate robust and flexible chassis strains for industrial product

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