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PRO_PHAGE SIGNED

Impact and interaction of prophage elements in bacterial host strains of biotechnological relevance

Total Cost €

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EC-Contrib. €

0

Partnership

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 PRO_PHAGE project word cloud

Explore the words cloud of the PRO_PHAGE project. It provides you a very rough idea of what is the project "PRO_PHAGE" about.

industrial    generation    added    dna    population    sequencing    triggers    earth    genome    chassis    applicable    metabolic    encoded    strains    regulatory    diverse    workflow    phage    throughput    dynamics    purpose    pursuing    improvement    engineering    host    virus    mutually    bacterial    fluorescence    immense    association    phages    insights    broadly    integration    sustainable    prey    pro    single    phenotyping    silencing    bacteriophages    resolution    activation    transition    risks    flexible    beneficial    activated    expression    traits    genetic    foreign    almost    generate    prophages    close    integrate    bioinformatic    molecular    analysed    ngs    explorative    evolution    microbes    microbial    hosts    viruses    decipher    abundant    significantly    bacteria    spontaneous    genomic    genomes    will    unexplored    ht    bioeconomy    proteins    reveal    compounds    inhabitants    subsequent    resource    unprecedented    xenogeneic    combining    product    shaped    temperate    sorting    gene    fitness    benchmarked    cell    interaction    illustrated   

Project "PRO_PHAGE" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSZENTRUM JULICH GMBH 

Organization address
address: WILHELM JOHNEN STRASSE
city: JULICH
postcode: 52428
website: www.fz-juelich.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙482˙672 €
 EC max contribution 1˙482˙672 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSZENTRUM JULICH GMBH DE (JULICH) coordinator 1˙482˙672.00

Map

 Project objective

Phages, viruses that prey on bacteria, are the most abundant and diverse inhabitants of the Earth. Temperate bacteriophages are able to integrate into the host genome and maintain as prophages a long-term association with their host. Illustrated by the development of mutually beneficial traits, this close interaction between host and virus has significantly shaped bacterial evolution. However, the immense genetic resources of phage genomes still remain almost unexplored. For the transition to a sustainable bioeconomy, we strongly depend on microbes as hosts for the production of value-added compounds. PRO_PHAGE will exploit recent advances in next-generation sequencing (NGS), single-cell analysis, and high-throughput (HT) phenotyping to evaluate the impact of phage elements on host fitness and to use this knowledge for the improvement of future metabolic engineering approaches. By combining an explorative approach with subsequent molecular analysis of selected targets, PRO_PHAGE will deliver novel insights into this genetic resource and will reveal the risks and potential for metabolic engineering by pursuing four major objectives. 1) Based on a comprehensive bioinformatic analysis, the impact of phage elements will be studied by HT phenotyping of selected strains. 2) The regulatory interaction of phage and host will be analysed by focusing on host-encoded xenogeneic silencing proteins and their role in the integration of foreign DNA. 3) The spontaneous activation of phage elements will be studied at the genomic scale to decipher molecular triggers and their impact on host gene expression. For this purpose, a novel workflow combining fluorescence-activated cell sorting and NGS will be developed, which will be broadly applicable for studying microbial population dynamics at unprecedented resolution. 4) Finally, the insights obtained will be benchmarked for metabolic engineering approaches in order to generate robust and flexible chassis strains for industrial product

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