Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. pro_phage

PRO_PHAGE SIGNED

Impact and interaction of prophage elements in bacterial host strains of biotechnological relevance

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PRO_PHAGE project word cloud

Explore the words cloud of the PRO_PHAGE project. It provides you a very rough idea of what is the project "PRO_PHAGE" about.

microbial    bacteria    earth    proteins    triggers    combining    association    fitness    fluorescence    chassis    host    bacteriophages    genomic    close    throughput    illustrated    encoded    applicable    single    evolution    explorative    activated    hosts    will    decipher    integration    gene    workflow    bacterial    broadly    ngs    pro    foreign    unexplored    risks    sustainable    pursuing    phage    spontaneous    reveal    generate    dynamics    molecular    added    analysed    abundant    significantly    regulatory    flexible    virus    metabolic    inhabitants    prey    strains    silencing    sorting    compounds    product    ht    engineering    resource    industrial    mutually    shaped    genome    viruses    bioinformatic    immense    generation    bioeconomy    temperate    microbes    integrate    genomes    beneficial    cell    expression    phenotyping    subsequent    dna    genetic    population    phages    benchmarked    sequencing    diverse    resolution    unprecedented    almost    transition    traits    xenogeneic    insights    interaction    prophages    activation    purpose    improvement   

Project "PRO_PHAGE" data sheet

The following table provides information about the project.

Coordinator		 FORSCHUNGSZENTRUM JULICH GMBH 

Organization address
address: WILHELM JOHNEN STRASSE
city: JULICH
postcode: 52428
website: www.fz-juelich.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Total cost 1˙482˙672 €
 EC max contribution 1˙482˙672 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSZENTRUM JULICH GMBH DE (JULICH) coordinator 1˙482˙672.00

Map

 Project objective

Phages, viruses that prey on bacteria, are the most abundant and diverse inhabitants of the Earth. Temperate bacteriophages are able to integrate into the host genome and maintain as prophages a long-term association with their host. Illustrated by the development of mutually beneficial traits, this close interaction between host and virus has significantly shaped bacterial evolution. However, the immense genetic resources of phage genomes still remain almost unexplored. For the transition to a sustainable bioeconomy, we strongly depend on microbes as hosts for the production of value-added compounds. PRO_PHAGE will exploit recent advances in next-generation sequencing (NGS), single-cell analysis, and high-throughput (HT) phenotyping to evaluate the impact of phage elements on host fitness and to use this knowledge for the improvement of future metabolic engineering approaches. By combining an explorative approach with subsequent molecular analysis of selected targets, PRO_PHAGE will deliver novel insights into this genetic resource and will reveal the risks and potential for metabolic engineering by pursuing four major objectives. 1) Based on a comprehensive bioinformatic analysis, the impact of phage elements will be studied by HT phenotyping of selected strains. 2) The regulatory interaction of phage and host will be analysed by focusing on host-encoded xenogeneic silencing proteins and their role in the integration of foreign DNA. 3) The spontaneous activation of phage elements will be studied at the genomic scale to decipher molecular triggers and their impact on host gene expression. For this purpose, a novel workflow combining fluorescence-activated cell sorting and NGS will be developed, which will be broadly applicable for studying microbial population dynamics at unprecedented resolution. 4) Finally, the insights obtained will be benchmarked for metabolic engineering approaches in order to generate robust and flexible chassis strains for industrial product

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PRO_PHAGE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PRO_PHAGE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More  

RODRESET (2019)

Development of novel optogenetic approaches for improving vision in macular degeneration

Read More