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PRO_PHAGE SIGNED

Impact and interaction of prophage elements in bacterial host strains of biotechnological relevance

Total Cost €

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EC-Contrib. €

0

Partnership

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 PRO_PHAGE project word cloud

Explore the words cloud of the PRO_PHAGE project. It provides you a very rough idea of what is the project "PRO_PHAGE" about.

single    microbes    temperate    decipher    regulatory    subsequent    generation    almost    will    foreign    silencing    purpose    bioeconomy    viruses    pursuing    unprecedented    sequencing    evolution    traits    bacteriophages    activated    molecular    resource    fitness    illustrated    encoded    insights    close    bacteria    earth    abundant    host    unexplored    significantly    compounds    beneficial    phages    bioinformatic    engineering    expression    dna    interaction    immense    industrial    improvement    hosts    resolution    applicable    explorative    fluorescence    sustainable    prey    integrate    flexible    spontaneous    proteins    genomic    integration    genome    reveal    shaped    pro    sorting    analysed    bacterial    prophages    broadly    generate    transition    inhabitants    workflow    product    genetic    genomes    strains    ht    diverse    benchmarked    microbial    metabolic    population    mutually    xenogeneic    cell    triggers    chassis    activation    combining    risks    gene    association    ngs    virus    throughput    dynamics    added    phage    phenotyping   

Project "PRO_PHAGE" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSZENTRUM JULICH GMBH 

Organization address
address: WILHELM JOHNEN STRASSE
city: JULICH
postcode: 52428
website: www.fz-juelich.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙482˙672 €
 EC max contribution 1˙482˙672 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSZENTRUM JULICH GMBH DE (JULICH) coordinator 1˙482˙672.00

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 Project objective

Phages, viruses that prey on bacteria, are the most abundant and diverse inhabitants of the Earth. Temperate bacteriophages are able to integrate into the host genome and maintain as prophages a long-term association with their host. Illustrated by the development of mutually beneficial traits, this close interaction between host and virus has significantly shaped bacterial evolution. However, the immense genetic resources of phage genomes still remain almost unexplored. For the transition to a sustainable bioeconomy, we strongly depend on microbes as hosts for the production of value-added compounds. PRO_PHAGE will exploit recent advances in next-generation sequencing (NGS), single-cell analysis, and high-throughput (HT) phenotyping to evaluate the impact of phage elements on host fitness and to use this knowledge for the improvement of future metabolic engineering approaches. By combining an explorative approach with subsequent molecular analysis of selected targets, PRO_PHAGE will deliver novel insights into this genetic resource and will reveal the risks and potential for metabolic engineering by pursuing four major objectives. 1) Based on a comprehensive bioinformatic analysis, the impact of phage elements will be studied by HT phenotyping of selected strains. 2) The regulatory interaction of phage and host will be analysed by focusing on host-encoded xenogeneic silencing proteins and their role in the integration of foreign DNA. 3) The spontaneous activation of phage elements will be studied at the genomic scale to decipher molecular triggers and their impact on host gene expression. For this purpose, a novel workflow combining fluorescence-activated cell sorting and NGS will be developed, which will be broadly applicable for studying microbial population dynamics at unprecedented resolution. 4) Finally, the insights obtained will be benchmarked for metabolic engineering approaches in order to generate robust and flexible chassis strains for industrial product

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