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MIPZ SIGNED

Functional characterization of the cell division inhibitor MipZ

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MIPZ project word cloud

Explore the words cloud of the MIPZ project. It provides you a very rough idea of what is the project "MIPZ" about.

mipz    releasing    deuterium    dimers    biophysical    dna    polar    unknown    disassembly    protein    fluorescence    limiting    characterizing    bipolar    near    complexes    offspring    conserved    generation    localization    simplistic    centromere    interact    thereby    divisome    division    hydrogen    monomers    immobilized    questions    dimerize    spontaneous    resonance    normal    positioning    loop    assembly    dimer    chromosomal    polymerization    microscale    inhibits    concentration    synthetic    spatiotemporal    antagonizing    hybrid    poles    crescentus    spectrometry    parb    cell    binding    biological    mass    inhibit    ftsz    mediated    surface    bound    cycle    rebuild    hydrolysis    combination    function    stimulates    midcell    microscopy    atp    thermophoresis    exchange    dynamic    gradients    recaptured    cytokinesis    interaction    plasmon    minimum    gradient    correct    dissociate    isolated    mutants    triggers    biochemistry    gain    techniques    atpase    caulobacter    manner    plane    form    previously    defects    diffusible    dependent    forming    centre   

Project "MIPZ" data sheet

The following table provides information about the project.

Coordinator
PHILIPPS UNIVERSITAET MARBURG 

Organization address
address: BIEGENSTRASSE 10
city: MARBURG
postcode: 35037
website: www.uni-marburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.thanbichlerlab.org/research.html
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-08-03   to  2018-04-09

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PHILIPPS UNIVERSITAET MARBURG DE (MARBURG) coordinator 159˙460.00

Map

 Project objective

Correct positioning of the division plane is essential for the generation of normal offspring. In Caulobacter crescentus, the spatiotemporal control of cell division is mediated by MipZ, a conserved P-loop ATPase forming bipolar gradients with a concentration minimum at the cell centre. Antagonizing the polymerization of the essential divisome component FtsZ, MipZ inhibits divisome assembly near the poles, thereby limiting cytokinesis to midcell. Gradient formation involves a dynamic localization cycle, in which freely diffusible MipZ monomers interact with polar complexes of the centromere-binding protein ParB and then dimerize in an ATP-dependent manner. Dimers dissociate from ParB and are immobilized within the cell through non-specific interaction with chromosomal DNA. Spontaneous ATP hydrolysis triggers disassembly of the complex, releasing MipZ monomers that are recaptured by ParB. How ParB stimulates dimer formation and how DNA-bound dimers inhibit FtsZ assembly is still unknown. We will address these questions by characterizing previously isolated MipZ mutants with FtsZ/ParB interaction defects, using a combination of fluorescence microscopy, two-hybrid analysis, biochemistry, and biophysical techniques such as surface plasmon resonance, microscale thermophoresis or hydrogen-deuterium-exchange mass spectrometry. We will also use synthetic biological and modelling approaches to rebuild the system in a simplistic form to thus gain in-depth knowledge of the function of the different elements.

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