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MIPZ SIGNED

Functional characterization of the cell division inhibitor MipZ

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MIPZ project word cloud

Explore the words cloud of the MIPZ project. It provides you a very rough idea of what is the project "MIPZ" about.

dimerize    caulobacter    localization    dna    thermophoresis    polar    spatiotemporal    resonance    defects    biophysical    disassembly    assembly    mutants    spontaneous    monomers    dynamic    antagonizing    recaptured    triggers    chromosomal    bipolar    crescentus    correct    parb    centre    techniques    atpase    gain    cell    gradient    loop    manner    cytokinesis    near    synthetic    deuterium    dimer    unknown    rebuild    divisome    thereby    dependent    division    diffusible    forming    mediated    plasmon    positioning    complexes    dissociate    immobilized    offspring    plane    cycle    conserved    centromere    exchange    mipz    form    combination    atp    dimers    isolated    normal    fluorescence    protein    hydrogen    polymerization    midcell    questions    mass    characterizing    stimulates    spectrometry    microscale    function    poles    interact    binding    surface    gradients    minimum    generation    simplistic    interaction    concentration    inhibits    inhibit    previously    ftsz    microscopy    biological    releasing    hybrid    biochemistry    bound    hydrolysis    limiting   

Project "MIPZ" data sheet

The following table provides information about the project.

Coordinator
PHILIPPS UNIVERSITAET MARBURG 

Organization address
address: BIEGENSTRASSE 10
city: MARBURG
postcode: 35037
website: www.uni-marburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.thanbichlerlab.org/research.html
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-08-03   to  2018-04-09

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PHILIPPS UNIVERSITAET MARBURG DE (MARBURG) coordinator 159˙460.00

Map

 Project objective

Correct positioning of the division plane is essential for the generation of normal offspring. In Caulobacter crescentus, the spatiotemporal control of cell division is mediated by MipZ, a conserved P-loop ATPase forming bipolar gradients with a concentration minimum at the cell centre. Antagonizing the polymerization of the essential divisome component FtsZ, MipZ inhibits divisome assembly near the poles, thereby limiting cytokinesis to midcell. Gradient formation involves a dynamic localization cycle, in which freely diffusible MipZ monomers interact with polar complexes of the centromere-binding protein ParB and then dimerize in an ATP-dependent manner. Dimers dissociate from ParB and are immobilized within the cell through non-specific interaction with chromosomal DNA. Spontaneous ATP hydrolysis triggers disassembly of the complex, releasing MipZ monomers that are recaptured by ParB. How ParB stimulates dimer formation and how DNA-bound dimers inhibit FtsZ assembly is still unknown. We will address these questions by characterizing previously isolated MipZ mutants with FtsZ/ParB interaction defects, using a combination of fluorescence microscopy, two-hybrid analysis, biochemistry, and biophysical techniques such as surface plasmon resonance, microscale thermophoresis or hydrogen-deuterium-exchange mass spectrometry. We will also use synthetic biological and modelling approaches to rebuild the system in a simplistic form to thus gain in-depth knowledge of the function of the different elements.

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