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Functional characterization of the cell division inhibitor MipZ

Total Cost €


EC-Contrib. €






 MIPZ project word cloud

Explore the words cloud of the MIPZ project. It provides you a very rough idea of what is the project "MIPZ" about.

protein    fluorescence    function    inhibits    biological    near    poles    rebuild    plasmon    localization    positioning    polar    cytokinesis    mass    thermophoresis    interaction    crescentus    exchange    dynamic    stimulates    techniques    polymerization    parb    conserved    dna    correct    spontaneous    concentration    simplistic    antagonizing    minimum    caulobacter    assembly    hybrid    microscopy    spatiotemporal    immobilized    defects    combination    hydrolysis    resonance    gradients    cycle    surface    monomers    complexes    dimer    diffusible    normal    characterizing    synthetic    midcell    cell    deuterium    ftsz    atp    gradient    dependent    triggers    centre    limiting    loop    chromosomal    plane    mipz    questions    manner    hydrogen    atpase    isolated    thereby    offspring    bipolar    division    microscale    interact    centromere    mutants    biochemistry    forming    form    binding    generation    divisome    inhibit    previously    bound    gain    releasing    unknown    mediated    recaptured    spectrometry    dimerize    dimers    dissociate    biophysical    disassembly   

Project "MIPZ" data sheet

The following table provides information about the project.


Organization address
postcode: 35037

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-08-03   to  2018-04-09


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Correct positioning of the division plane is essential for the generation of normal offspring. In Caulobacter crescentus, the spatiotemporal control of cell division is mediated by MipZ, a conserved P-loop ATPase forming bipolar gradients with a concentration minimum at the cell centre. Antagonizing the polymerization of the essential divisome component FtsZ, MipZ inhibits divisome assembly near the poles, thereby limiting cytokinesis to midcell. Gradient formation involves a dynamic localization cycle, in which freely diffusible MipZ monomers interact with polar complexes of the centromere-binding protein ParB and then dimerize in an ATP-dependent manner. Dimers dissociate from ParB and are immobilized within the cell through non-specific interaction with chromosomal DNA. Spontaneous ATP hydrolysis triggers disassembly of the complex, releasing MipZ monomers that are recaptured by ParB. How ParB stimulates dimer formation and how DNA-bound dimers inhibit FtsZ assembly is still unknown. We will address these questions by characterizing previously isolated MipZ mutants with FtsZ/ParB interaction defects, using a combination of fluorescence microscopy, two-hybrid analysis, biochemistry, and biophysical techniques such as surface plasmon resonance, microscale thermophoresis or hydrogen-deuterium-exchange mass spectrometry. We will also use synthetic biological and modelling approaches to rebuild the system in a simplistic form to thus gain in-depth knowledge of the function of the different elements.

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The information about "MIPZ" are provided by the European Opendata Portal: CORDIS opendata.

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